{"id":"https://openalex.org/W2025718664","doi":"https://doi.org/10.1109/hpcsim.2011.5999793","title":"HPCS 2011 keynotes: Tuesday keynote I: High-performance computing and biology: The quest for a predictive biological theory","display_name":"HPCS 2011 keynotes: Tuesday keynote I: High-performance computing and biology: The quest for a predictive biological theory","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W2025718664","doi":"https://doi.org/10.1109/hpcsim.2011.5999793","mag":"2025718664"},"language":"en","primary_location":{"id":"doi:10.1109/hpcsim.2011.5999793","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2011.5999793","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 International Conference on High Performance Computing & Simulation","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053682943","display_name":"Rick Stevens","orcid":"https://orcid.org/0000-0002-4268-4020"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rick L. Stevens","raw_affiliation_strings":["Argonne National Laboratory, The University of Chicago, Illinois, USA","Argonne National Laboratory and The University of Chicago, Illinois, USA"],"affiliations":[{"raw_affiliation_string":"Argonne National Laboratory, The University of Chicago, Illinois, USA","institution_ids":["https://openalex.org/I1282105669","https://openalex.org/I40347166"]},{"raw_affiliation_string":"Argonne National Laboratory and The University of Chicago, Illinois, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053682943"],"corresponding_institution_ids":["https://openalex.org/I39422238","https://openalex.org/I1282105669","https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0841457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9474999904632568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9258999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6983296275138855},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.6832622289657593},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5707496404647827},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.539377748966217},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5089831352233887},{"id":"https://openalex.org/keywords/big-data","display_name":"Big data","score":0.43323010206222534},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.288891077041626},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.25788259506225586},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22557717561721802},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.19026604294776917},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.11135897040367126}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6983296275138855},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.6832622289657593},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5707496404647827},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.539377748966217},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5089831352233887},{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.43323010206222534},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.288891077041626},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.25788259506225586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22557717561721802},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.19026604294776917},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.11135897040367126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/hpcsim.2011.5999793","is_oa":false,"landing_page_url":"https://doi.org/10.1109/hpcsim.2011.5999793","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 International Conference on High Performance Computing & Simulation","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322629366","https://openalex.org/W2808989540","https://openalex.org/W2397053934","https://openalex.org/W1039292361","https://openalex.org/W2551093110","https://openalex.org/W2148016376","https://openalex.org/W4237919137","https://openalex.org/W3184179822","https://openalex.org/W3095362084","https://openalex.org/W3003361536"],"abstract_inverted_index":{"In":[0],"this":[1],"talk":[2],"we":[3,86,165],"will":[4,46,83,129,153,166],"discuss":[5,47,167],"the":[6,18,48,132,139,147,168,179],"role":[7,49,74],"that":[8,50,116,170],"high-performance":[9,67],"computing":[10,68,135],"and":[11,29,40,65,101,105,146,181],"advanced":[12],"data":[13,41,92,150],"systems":[14,37,107],"play":[15],"in":[16,57,62,75,134,141,155],"accelerating":[17],"transition":[19],"of":[20,79,98,149,159],"biology":[21],"from":[22,88],"a":[23,32,72,124,156],"science":[24,34],"primarily":[25],"focused":[26,35],"on":[27,36,176],"description":[28],"explanation":[30],"to":[31,93,113],"new":[33,77],"level":[38],"understanding":[39],"driven":[42,52],"predictive":[43,94,171],"theories.":[44],"We":[45,82,128],"genomics":[51],"biological":[53,63,80,99,111,142,172],"models":[54,97,173],"are":[55,70,108],"playing":[56,71],"reshaping":[58],"what":[59],"is":[60],"possible":[61,119],"analysis":[64,106],"how":[66,85,102,131],"technologies":[69],"critical":[73],"enabling":[76,109],"types":[78],"investigations.":[81],"outline":[84],"go":[87],"raw":[89],"DNA":[90],"sequence":[91,143],"whole":[95],"genome":[96],"phenotype":[100],"automated":[103],"annotation":[104],"small":[110],"labs":[112],"do":[114],"things":[115],"were":[117],"not":[118],"at":[120],"any":[121],"scale":[122],"just":[123],"few":[125],"years":[126],"ago.":[127],"project":[130],"increases":[133,140],"capability":[136],"coupled":[137],"with":[138],"generation":[144],"throughput":[145],"rise":[148],"integration":[151],"methods":[152],"result":[154],"rapid":[157],"expansion":[158],"our":[160],"understanding.":[161],"If":[162],"time":[163],"permits,":[164],"impact":[169],"can":[174],"have":[175],"health,":[177],"energy,":[178],"environment":[180],"science.":[182]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}