{"id":"https://openalex.org/W4389576932","doi":"https://doi.org/10.1109/embc40787.2023.10340635","title":"Hyper-Connected Transformer Network for Multi-Modality PET-CT Segmentation","display_name":"Hyper-Connected Transformer Network for Multi-Modality PET-CT Segmentation","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4389576932","doi":"https://doi.org/10.1109/embc40787.2023.10340635","pmid":"https://pubmed.ncbi.nlm.nih.gov/38083369"},"language":"en","primary_location":{"id":"doi:10.1109/embc40787.2023.10340635","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10340635","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015039086","display_name":"Lei Bi","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Bi","raw_affiliation_strings":["Shanghai Jiao Tong University,Institute of Translational Medicine, National Center for Translational Medicine,Shanghai,China","Institute of Translational Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University,Institute of Translational Medicine, National Center for Translational Medicine,Shanghai,China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Institute of Translational Medicine, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082979981","display_name":"Michael Fulham","orcid":"https://orcid.org/0000-0003-0602-6319"},"institutions":[{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael Fulham","raw_affiliation_strings":["Royal Prince Alfred Hospital,Department of Molecular Imaging,NSW,Australia","Department of Molecular Imaging, Royal Prince Alfred Hospital, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Prince Alfred Hospital,Department of Molecular Imaging,NSW,Australia","institution_ids":["https://openalex.org/I2799732068"]},{"raw_affiliation_string":"Department of Molecular Imaging, Royal Prince Alfred Hospital, NSW, Australia","institution_ids":["https://openalex.org/I2799732068"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087860365","display_name":"Shaoli Song","orcid":"https://orcid.org/0000-0003-2544-7522"},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoli Song","raw_affiliation_strings":["Fudan University Shanghai Cancer Center, Fudan University,Department of Nuclear Medicine,Shanghai,China","Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University Shanghai Cancer Center, Fudan University,Department of Nuclear Medicine,Shanghai,China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068891693","display_name":"Dagan Feng","orcid":"https://orcid.org/0000-0002-3381-214X"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Dagan Feng","raw_affiliation_strings":["University of Sydney,School of Computer Science,NSW,Australia","School of Computer Science, University of Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sydney,School of Computer Science,NSW,Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Computer Science, University of Sydney, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100614820","display_name":"Jinman Kim","orcid":"https://orcid.org/0000-0001-5960-1060"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jinman Kim","raw_affiliation_strings":["University of Sydney,School of Computer Science,NSW,Australia","School of Computer Science, University of Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sydney,School of Computer Science,NSW,Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Computer Science, University of Sydney, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4386,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.68442712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"2023","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6836997866630554},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6478266716003418},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6423547267913818},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.5184623599052429},{"id":"https://openalex.org/keywords/modality","display_name":"Modality (human\u2013computer interaction)","score":0.5139934420585632},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5074638724327087},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.44715118408203125},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"Computed tomography","score":0.42376774549484253},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.41188570857048035},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.40689074993133545},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.20446956157684326},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17321255803108215}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6836997866630554},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6478266716003418},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6423547267913818},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5184623599052429},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.5139934420585632},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5074638724327087},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.44715118408203125},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.42376774549484253},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.41188570857048035},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.40689074993133545},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.20446956157684326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17321255803108215},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc40787.2023.10340635","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc40787.2023.10340635","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:38083369","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38083369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2049514035","https://openalex.org/W2099698084","https://openalex.org/W2107166114","https://openalex.org/W2194775991","https://openalex.org/W2395611524","https://openalex.org/W2782993895","https://openalex.org/W2895328943","https://openalex.org/W2992749535","https://openalex.org/W3106286734","https://openalex.org/W3127751679","https://openalex.org/W3130171175","https://openalex.org/W3131500599","https://openalex.org/W3136763234","https://openalex.org/W3170841864","https://openalex.org/W3189898414","https://openalex.org/W3203480968","https://openalex.org/W3204166336"],"related_works":["https://openalex.org/W2385859805","https://openalex.org/W2530972254","https://openalex.org/W2374013449","https://openalex.org/W73545470","https://openalex.org/W2364381299","https://openalex.org/W2374430585","https://openalex.org/W3144423903","https://openalex.org/W2377397762","https://openalex.org/W2793967660","https://openalex.org/W1522196789"],"abstract_inverted_index":{"[18F]-Fluorodeoxyglucose":[0],"(FDG)":[1],"positron":[2],"emission":[3],"tomography":[4,7],"-":[5],"computed":[6],"(PET-CT)":[8],"has":[9],"become":[10],"the":[11,100,124,155],"imaging":[12,23],"modality":[13],"of":[14,103],"choice":[15],"for":[16,29,34,62,70,181],"diagnosing":[17],"many":[18],"cancers.":[19],"Co-learning":[20],"complementary":[21,127],"PET-CT":[22,64],"features":[24,129],"is":[25],"a":[26,46,53,58,90,118],"fundamental":[27],"requirement":[28],"automatic":[30],"tumor":[31,174],"segmentation":[32,150],"and":[33,126,167,176],"developing":[35],"computer":[36],"aided":[37],"cancer":[38,182],"diagnosis":[39],"systems.":[40],"In":[41],"this":[42],"study,":[43],"we":[44],"propose":[45],"hyper-connected":[47],"transformer":[48,54],"(HCT)":[49],"network":[50,55],"that":[51,144,160],"integrates":[52],"(TN)":[56],"with":[57,89,105,139],"hyper":[59,119],"connected":[60,120],"fusion":[61,121],"multi-modality":[63],"images.":[65],"The":[66],"TN":[67,104,107],"was":[68,82],"leveraged":[69],"its":[71],"ability":[72],"to":[73,93,110,122,154,170],"provide":[74],"global":[75],"dependencies":[76],"in":[77,133,149,173,177],"image":[78,86,113,128,179],"feature":[79],"learning,":[80],"which":[81],"achieved":[83,146],"by":[84],"using":[85],"patch":[87],"embeddings":[88],"self-attention":[91],"mechanism":[92],"capture":[94],"image-wide":[95],"contextual":[96,125],"information.":[97],"We":[98,115],"extended":[99],"single-modality":[101],"definition":[102],"multiple":[106,131],"based":[108],"branches":[109],"separately":[111],"extract":[112],"features.":[114],"also":[116],"introduced":[117],"fuse":[123],"across":[130],"transformers":[132],"an":[134,165],"iterative":[135],"manner.":[136],"Our":[137],"results":[138],"two":[140],"clinical":[141],"datasets":[142],"show":[143],"HCT":[145],"better":[147],"performance":[148],"accuracy":[151],"when":[152],"compared":[153],"existing":[156],"methods.Clinical":[157],"Relevance-We":[158],"anticipate":[159],"our":[161],"approach":[162],"can":[163],"be":[164],"effective":[166],"supportive":[168],"tool":[169],"aid":[171],"physicians":[172],"quantification":[175],"identifying":[178],"biomarkers":[180],"treatment.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2023-12-12T00:00:00"}