{"id":"https://openalex.org/W2979699216","doi":"https://doi.org/10.1109/embc.2019.8856373","title":"A System for Combined Laser Doppler Flowmetry and Microelectrode Recording during Deep Brain Stimulation Implantation","display_name":"A System for Combined Laser Doppler Flowmetry and Microelectrode Recording during Deep Brain Stimulation Implantation","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2979699216","doi":"https://doi.org/10.1109/embc.2019.8856373","mag":"2979699216","pmid":"https://pubmed.ncbi.nlm.nih.gov/31946692"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2019.8856373","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856373","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032296811","display_name":"Karin W\u00e5rdell","orcid":"https://orcid.org/0000-0002-0012-7867"},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karin Wardell","raw_affiliation_strings":["Department of Biomedical Engineering, Link\u00f6ping University, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072831806","display_name":"Peter Zsigmond","orcid":"https://orcid.org/0000-0003-3982-7745"},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peter Zsigmond","raw_affiliation_strings":["Department of Neurosurgery, and the Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, and the Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049069962","display_name":"Simone Hemm","orcid":"https://orcid.org/0000-0002-5726-6761"},"institutions":[{"id":"https://openalex.org/I102134673","display_name":"Link\u00f6ping University","ror":"https://ror.org/05ynxx418","country_code":"SE","type":"education","lineage":["https://openalex.org/I102134673"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Simone Hemm","raw_affiliation_strings":["Department of Biomedical Engineering, Link\u00f6ping University, Link\u00f6ping, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Link\u00f6ping University, Link\u00f6ping, Sweden","institution_ids":["https://openalex.org/I102134673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102134673"],"apc_list":null,"apc_paid":null,"fwci":0.1575,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55602434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"1","issue":null,"first_page":"3758","last_page":"3761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-doppler-velocimetry","display_name":"Laser Doppler velocimetry","score":0.8748683929443359},{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.8062185645103455},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.7029133439064026},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.5973638296127319},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"Subthalamic nucleus","score":0.5893725156784058},{"id":"https://openalex.org/keywords/microcirculation","display_name":"Microcirculation","score":0.5377734899520874},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4776548147201538},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.4538031220436096},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4326298236846924},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.41347622871398926},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3361992835998535},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.25422120094299316},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15132921934127808},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.12438377737998962},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.11240878701210022},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.10893240571022034},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.09273341298103333}],"concepts":[{"id":"https://openalex.org/C52305850","wikidata":"https://www.wikidata.org/wiki/Q1420475","display_name":"Laser Doppler velocimetry","level":3,"score":0.8748683929443359},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.8062185645103455},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.7029133439064026},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5973638296127319},{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.5893725156784058},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5377734899520874},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4776548147201538},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4538031220436096},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4326298236846924},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.41347622871398926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3361992835998535},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.25422120094299316},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15132921934127808},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12438377737998962},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.11240878701210022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10893240571022034},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.09273341298103333},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017078","descriptor_name":"Laser-Doppler Flowmetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017078","descriptor_name":"Laser-Doppler Flowmetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017078","descriptor_name":"Laser-Doppler Flowmetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2019.8856373","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2019.8856373","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:31946692","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31946692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1571915222","https://openalex.org/W1985176577","https://openalex.org/W2002415146","https://openalex.org/W2017069734","https://openalex.org/W2022336272","https://openalex.org/W2045249516","https://openalex.org/W2097751385","https://openalex.org/W2099661425","https://openalex.org/W2139075756","https://openalex.org/W2156785179","https://openalex.org/W2775553203","https://openalex.org/W2781862854"],"related_works":["https://openalex.org/W2093780015","https://openalex.org/W4289755640","https://openalex.org/W4301179225","https://openalex.org/W2607326016","https://openalex.org/W1983965289","https://openalex.org/W22241804","https://openalex.org/W1564112868","https://openalex.org/W1988702215","https://openalex.org/W1997179847","https://openalex.org/W2913536894"],"abstract_inverted_index":{"Microelectrode":[0],"recording":[1],"(MER)":[2],"and":[3,35,44,129],"intraoperative":[4],"test":[5],"stimulations":[6],"are":[7],"commonly":[8],"used":[9],"during":[10,126,177,193],"stereotactic":[11],"implantation":[12],"of":[13,25,29,60,75,121],"deep":[14],"brain":[15],"stimulation":[16],"(DBS)":[17],"electrodes":[18],"but":[19],"they":[20],"can":[21],"increase":[22],"the":[23,30,57,61,76,80,102,109,112,118,122,137,158,163],"risk":[24],"hemorrhage.":[26],"The":[27,133],"aim":[28],"study":[31],"is":[32],"to":[33,162,174,186],"present":[34],"evaluate":[36],"a":[37,65,171],"system":[38],"combining":[39],"laser":[40],"Doppler":[41],"flowmetry":[42],"(LDF)":[43],"MER.":[45],"An":[46],"optical":[47,155],"probe":[48,63,78,125,156,165],"was":[49,87],"designed":[50],"with":[51,79,142,150],"an":[52,154],"inner":[53],"metal":[54],"tube":[55],"for":[56],"microelectrode.":[58],"Calibration":[59],"MER-LDF":[62,124],"in":[64,90,111,130,189],"standard":[66],"microsphere":[67],"solution":[68],"showed":[69,139],"expected":[70],"LDF":[71,81,86,97],"pattern.":[72],"No":[73],"interferences":[74],"MER":[77,159,178],"signals":[82],"could":[83,183],"be":[84,184],"observed.":[85],"also":[88],"acquired":[89],"one":[91,131],"Parkinson":[92],"patient":[93],"undergoing":[94],"DBS":[95],"implantation.":[96],"data":[98],"were":[99],"obtained":[100],"along":[101],"precalculated":[103],"trajectory":[104],"i.e.":[105],"from":[106,145],"cortex":[107],"towards":[108],"target":[110],"subthalamic":[113],"nucleus":[114],"(STN).":[115],"Results":[116],"demonstrated":[117],"technical":[119],"feasibility":[120],"combined":[123],"in-vitro":[127],"experiences":[128],"patient.":[132],"perfusion":[134],"signal":[135],"representing":[136],"microcirculation":[138],"stable":[140],"values":[141],"clear":[143],"peaks":[144],"each":[146],"heartbeat.":[147],"This":[148],"agreed":[149],"previous":[151],"investigation":[152],"using":[153],"without":[157],"function.":[160],"Due":[161],"forward-looking":[164],"design,":[166],"this":[167],"new":[168],"technology":[169],"has":[170],"high":[172],"potential":[173],"avoid":[175],"vessels":[176],"recording.":[179],"In":[180],"addition,":[181],"it":[182],"possible":[185],"detect":[187],"changes":[188],"microcirculatory":[190],"blood":[191],"flow":[192],"stimulation.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}