{"id":"https://openalex.org/W2534639613","doi":"https://doi.org/10.1109/embc.2016.7590659","title":"Forecasting nanoparticle toxicity using nonlinear predictive regressor learning systems","display_name":"Forecasting nanoparticle toxicity using nonlinear predictive regressor learning systems","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2534639613","doi":"https://doi.org/10.1109/embc.2016.7590659","mag":"2534639613","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268298"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7590659","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590659","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010629974","display_name":"Nicola Toschi","orcid":"https://orcid.org/0000-0003-1929-5833"},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT","US"],"is_corresponding":true,"raw_author_name":"N. Toschi","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA","Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA","institution_ids":["https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013026922","display_name":"Stefano Ciulli","orcid":"https://orcid.org/0000-0002-9386-3088"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Ciulli","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy","Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Clinical and Experimental Biomedical Sciences, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069829029","display_name":"Stefano Diciotti","orcid":"https://orcid.org/0000-0001-8778-7819"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Diciotti","raw_affiliation_strings":["Department of Electrical, Electronic, University of Bologna, Cesena (FC), Italy"],"affiliations":[{"raw_affiliation_string":"Department of Electrical, Electronic, University of Bologna, Cesena (FC), Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025775404","display_name":"Andrea Duggento","orcid":"https://orcid.org/0000-0001-6030-5269"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Duggento","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048596584","display_name":"Maria Guerrisi","orcid":"https://orcid.org/0000-0002-7456-4349"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Guerrisi","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010941461","display_name":"Andrea Magrini","orcid":"https://orcid.org/0000-0002-3539-149X"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Magrini","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021139262","display_name":"Luisa Campagnolo","orcid":"https://orcid.org/0000-0003-3928-0276"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Campagnolo","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067004616","display_name":"Antonio Pietroiusti","orcid":"https://orcid.org/0000-0002-4056-1801"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Pietroiusti","raw_affiliation_strings":["Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \u201cTor Vergata\u201d, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biomedicine and Prevention, University of Rome \"Tor Vergata\", Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5010629974"],"corresponding_institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4210127055"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.12075762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2016","issue":null,"first_page":"137","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9718999862670898,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9718999862670898,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5726735591888428},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4960218369960785},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47195783257484436},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4596966803073883},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4563709795475006},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.44650697708129883},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.43382757902145386},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"Cytotoxicity","score":0.43056678771972656},{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.41867300868034363},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3886169195175171},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20009201765060425},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11430498957633972}],"concepts":[{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5726735591888428},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4960218369960785},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47195783257484436},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4596966803073883},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4563709795475006},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.44650697708129883},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.43382757902145386},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.43056678771972656},{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.41867300868034363},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3886169195175171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20009201765060425},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11430498957633972},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc.2016.7590659","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590659","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268298","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:art.torvergata.it:2108/185745","is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/185745","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bookPart"},{"id":"pmh:oai:cris.unibo.it:11585/592261","is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/592261","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2030005642","https://openalex.org/W2038246612","https://openalex.org/W2043210179","https://openalex.org/W2044794349","https://openalex.org/W2050125927","https://openalex.org/W2110357734","https://openalex.org/W2127654256","https://openalex.org/W2138392219","https://openalex.org/W2139104477","https://openalex.org/W2143771199","https://openalex.org/W2146512855","https://openalex.org/W2158771254","https://openalex.org/W2163842752","https://openalex.org/W2165803245","https://openalex.org/W2166710455"],"related_works":["https://openalex.org/W2366562690","https://openalex.org/W2796949944","https://openalex.org/W2395219877","https://openalex.org/W3092521730","https://openalex.org/W2045299745","https://openalex.org/W3152230514","https://openalex.org/W3147138563","https://openalex.org/W891673278","https://openalex.org/W2550904580","https://openalex.org/W2963653239"],"abstract_inverted_index":{"Nanoparticle":[0],"(NP)":[1],"toxicity":[2,114,175,205,219],"is":[3,34],"determined":[4],"by":[5,117],"a":[6,19,105],"vast":[7],"number":[8,182],"of":[9,22,25,62,78,183],"topological,":[10],"sterical,":[11],"physico-chemical":[12],"as":[13,15,30,32,115],"well":[14],"biological":[16,28],"properties,":[17],"rendering":[18],"priori":[20],"evaluation":[21],"the":[23,42,60,76,124,166,169,181,199],"effect":[24],"NP":[26,47,64,71,84,133,243],"on":[27,82],"tissue":[29],"arduous":[31],"it":[33],"necessary":[35],"and":[36,66,85,98,120,144,153,173,198,225],"urgent.":[37],"We":[38],"aimed":[39],"at":[40],"mining":[41],"HORIZON":[43],"2020":[44],"MODENA":[45],"COST":[46],"cytotoxicity":[48,79,244],"database":[49],"through":[50],"nonlinear":[51,89],"predictive":[52],"regressor":[53,159],"learning":[54,160,237],"systems":[55],"in":[56,69,155,203,239],"order":[57],"to":[58,112,209],"assess":[59],"power":[61],"available":[63],"descriptors":[65],"assay":[67],"characteristics":[68],"predicting":[70,204],"toxicity.":[72],"Specifically,":[73],"we":[74],"assessed":[75],"results":[77],"assays":[80],"performed":[81],"57":[83],"trained":[86],"two":[87],"different":[88],"regressors":[90],"(Support":[91],"Vector":[92],"Regressors":[93],"[SVR]":[94],"with":[95,165,180,195,230],"polynomical":[96],"kernels":[97],"Radial":[99],"Basis":[100],"Function":[101],"[RBF]":[102],"regressors)":[103],"within":[104],"nested-cross":[106],"validation":[107],"scheme":[108],"for":[109,129],"parameter":[110],"optimization":[111],"predict":[113],"quantified":[116],"EC25,":[118,223],"EC50":[119,224],"slope":[121,226],"while":[122],"using":[123,233],"regressional":[125],"ReliefF":[126],"algorithm":[127],"(RReliefF)":[128],"feature":[130,163],"selection.":[131],"Available":[132],"attributes":[134],"were":[135,207],"material,":[136],"coating,":[137],"cell":[138],"type,":[139],"dispersion":[140],"protocol,":[141],"shape,":[142],"1st":[143],"2nd":[145],"dimension,":[146],"aspect":[147],"ratio,":[148],"surface":[149],"area,":[150],"zeta":[151],"potential":[152],"size":[154],"situ.":[156],"In":[157,221],"most":[158,200],"systems,":[161],"after":[162],"selection":[164],"RReliefF":[167],"algorithm,":[168],"correlation":[170,232],"between":[171,218],"real":[172],"estimated":[174],"endpoint":[176],"values":[177,187],"increased":[178],"monotonically":[179],"included":[184],"features,":[185],"reaching":[186],"above":[188],"0.90.":[189],"The":[190],"best":[191],"performance":[192],"was":[193],"obtained":[194],"RBF":[196],"regressors,":[197],"informative":[201],"features":[202],"endpoints":[206],"related":[208],"nanoparticle":[210],"structure.":[211],"These":[212],"trends":[213],"did":[214],"not":[215],"change":[216],"significantly":[217],"endpoints.":[220],"conclusion,":[222],"can":[227],"be":[228],"predicted":[229],"high":[231],"purely":[234],"data-driven,":[235],"machine":[236],"methods":[238],"Adenosine":[240],"triphosphate":[241],"(ATP)-based":[242],"assays.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
