{"id":"https://openalex.org/W2322583582","doi":"https://doi.org/10.1109/embc.2014.6945038","title":"Human pluripotent stem cell tools for cardiac optogenetics","display_name":"Human pluripotent stem cell tools for cardiac optogenetics","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2322583582","doi":"https://doi.org/10.1109/embc.2014.6945038","mag":"2322583582","pmid":"https://pubmed.ncbi.nlm.nih.gov/25571406"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6945038","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6945038","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025504883","display_name":"Yan Zhuge","orcid":"https://orcid.org/0000-0003-1620-6743"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yan Zhuge","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056961870","display_name":"Bhagat Patlolla","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhagat Patlolla","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036728423","display_name":"Charu Ramakrishnan","orcid":"https://orcid.org/0000-0002-3474-6332"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charu Ramakrishnan","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030523372","display_name":"Ramin E. Beygui","orcid":"https://orcid.org/0000-0002-2972-7698"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramin E. Beygui","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003894791","display_name":"Christopher K. Zarins","orcid":"https://orcid.org/0000-0001-6179-1000"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher K. Zarins","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014360828","display_name":"Karl Deisseroth","orcid":"https://orcid.org/0000-0001-9440-3967"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Deisseroth","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073356597","display_name":"Ellen Kuhl","orcid":"https://orcid.org/0000-0002-6283-935X"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Kuhl","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089782051","display_name":"Oscar J. Abilez","orcid":"https://orcid.org/0000-0002-9991-400X"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar J. Abilez","raw_affiliation_strings":["Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine Division, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025504883"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":0.9431,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.70541294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"318","issue":null,"first_page":"6171","last_page":"6174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optogenetics","display_name":"Optogenetics","score":0.834988534450531},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.6719508767127991},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.6179378032684326},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.5730100274085999},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5159193277359009},{"id":"https://openalex.org/keywords/channelrhodopsin","display_name":"Channelrhodopsin","score":0.5132243633270264},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.39536967873573303},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35868337750434875},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3547486662864685},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.33260905742645264},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2837538719177246},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14393967390060425},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08541831374168396}],"concepts":[{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.834988534450531},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6719508767127991},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6179378032684326},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5730100274085999},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5159193277359009},{"id":"https://openalex.org/C37218471","wikidata":"https://www.wikidata.org/wiki/Q905325","display_name":"Channelrhodopsin","level":3,"score":0.5132243633270264},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39536967873573303},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35868337750434875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3547486662864685},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33260905742645264},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2837538719177246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14393967390060425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08541831374168396}],"mesh":[{"descriptor_ui":"D000075402","descriptor_name":"Channelrhodopsins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075402","descriptor_name":"Channelrhodopsins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075402","descriptor_name":"Channelrhodopsins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6945038","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6945038","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25571406","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25571406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1965380680","https://openalex.org/W1978253480","https://openalex.org/W2001406655","https://openalex.org/W2023732600","https://openalex.org/W2026563267","https://openalex.org/W2036169480","https://openalex.org/W2049717499","https://openalex.org/W2055697048","https://openalex.org/W2065168340","https://openalex.org/W2087776156","https://openalex.org/W2088186055","https://openalex.org/W2101038486","https://openalex.org/W2104790299","https://openalex.org/W2108846059","https://openalex.org/W2108903695","https://openalex.org/W2110181951","https://openalex.org/W2128085444","https://openalex.org/W2138977668","https://openalex.org/W2140332303","https://openalex.org/W2142046859","https://openalex.org/W2161311376","https://openalex.org/W2167095271","https://openalex.org/W2295212086"],"related_works":["https://openalex.org/W3174750407","https://openalex.org/W2422786862","https://openalex.org/W2040631236","https://openalex.org/W1501307841","https://openalex.org/W4402168949","https://openalex.org/W4309618977","https://openalex.org/W2149787863","https://openalex.org/W2125204606","https://openalex.org/W2809615559","https://openalex.org/W1579620866"],"abstract_inverted_index":{"It":[0],"is":[1,59,106],"likely":[2],"that":[3,108,122],"arrhythmias":[4],"should":[5],"be":[6,20,54,99],"avoided":[7],"for":[8,149],"therapies":[9],"based":[10],"on":[11],"human":[12,40],"pluripotent":[13],"stem":[14,42],"cell":[15],"(hPSC)-derived":[16],"cardiomyocytes":[17],"(CM)":[18],"to":[19,53,77,82],"effective.":[21],"Towards":[22],"achieving":[23],"this":[24,123],"goal,":[25],"we":[26],"introduced":[27],"light-activated":[28],"channelrhodopsin-2":[29],"(ChR2),":[30],"a":[31,66,109],"cation":[32],"channel":[33],"activated":[34,55,100],"with":[35,56,144,155],"480":[36],"nm":[37],"light,":[38],"into":[39,62],"embryonic":[41],"cells":[43],"(hESC).":[44],"By":[45],"using":[46],"in":[47,115,139],"vitro":[48,116],"approaches,":[49],"hESC-CM":[50,120],"are":[51,73],"able":[52],"light.":[57],"ChR2":[58],"stably":[60],"transduced":[61],"undifferentiated":[63],"hESC":[64],"via":[65],"lentiviral":[67],"vector.":[68],"Via":[69],"directed":[70],"differentiation,":[71],"hESC(ChR2)-CM":[72,80,97],"produced":[74],"and":[75,86,121,132],"subjected":[76],"optical":[78,102,117,141,145],"stimulation.":[79,103],"respond":[81],"traditional":[83],"electrical":[84],"stimulation":[85,130,142],"produce":[87],"similar":[88],"contractility":[89],"features":[90],"as":[91],"their":[92],"wild-type":[93],"counterparts":[94],"but":[95],"only":[96],"can":[98,113],"by":[101],"Here":[104],"it":[105],"shown":[107],"light":[110,129],"sensitive":[111],"protein":[112],"enable":[114],"control":[118],"of":[119,152],"activation":[124],"occurs":[125],"optimally":[126],"above":[127],"specific":[128],"intensity":[131],"pulse":[133],"width":[134],"thresholds.":[135],"For":[136],"future":[137],"therapy,":[138],"vivo":[140],"along":[143],"inhibition":[146],"could":[147],"allow":[148],"acute":[150],"synchronization":[151],"implanted":[153],"hPSC-CM":[154],"patient":[156],"cardiac":[157],"rhythms.":[158]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}