{"id":"https://openalex.org/W2321509392","doi":"https://doi.org/10.1109/embc.2014.6945032","title":"A new paradigm for treatment of glaucoma","display_name":"A new paradigm for treatment of glaucoma","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2321509392","doi":"https://doi.org/10.1109/embc.2014.6945032","mag":"2321509392","pmid":"https://pubmed.ncbi.nlm.nih.gov/25571400"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6945032","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6945032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109185972","display_name":"Robert L. Galloway","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert L. Galloway","raw_affiliation_strings":["Vanderbilt Dept. of BME, Nashville, TN"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Dept. of BME, Nashville, TN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027889511","display_name":"Michael P. DeLisi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Delisi","raw_affiliation_strings":["Vanderbilt Dept. of BME, Nashville, TN"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Dept. of BME, Nashville, TN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007452156","display_name":"Eva Harth","orcid":"https://orcid.org/0000-0001-5553-0365"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva M. Harth","raw_affiliation_strings":["Vanderbilt Dept. of Chemistry"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Dept. of Chemistry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079871623","display_name":"Louise A. Mawn","orcid":"https://orcid.org/0000-0001-5123-7495"},"institutions":[{"id":"https://openalex.org/I4210162197","display_name":"Vanderbilt Health","ror":"https://ror.org/05grhsk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210162197"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise A. Mawn","raw_affiliation_strings":["Vanderbilt Dept. of Ophthalmology"],"affiliations":[{"raw_affiliation_string":"Vanderbilt Dept. of Ophthalmology","institution_ids":["https://openalex.org/I4210162197"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109185972"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.24878976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"8","issue":null,"first_page":"6147","last_page":"6150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"Glaucoma","score":0.706293523311615},{"id":"https://openalex.org/keywords/blindness","display_name":"Blindness","score":0.639887273311615},{"id":"https://openalex.org/keywords/ex-vivo","display_name":"Ex vivo","score":0.6276942491531372},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48064127564430237},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.41392242908477783},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.36377114057540894},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.351374089717865},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.34213611483573914},{"id":"https://openalex.org/keywords/optometry","display_name":"Optometry","score":0.27160531282424927},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23850810527801514},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.2217811644077301},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2173956036567688},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09572488069534302}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.706293523311615},{"id":"https://openalex.org/C2780929884","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Blindness","level":2,"score":0.639887273311615},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6276942491531372},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48064127564430237},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.41392242908477783},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.36377114057540894},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.351374089717865},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.34213611483573914},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.27160531282424927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23850810527801514},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2217811644077301},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2173956036567688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09572488069534302},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001766","descriptor_name":"Blindness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6945032","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6945032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25571400","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25571400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W46341933","https://openalex.org/W1913827328","https://openalex.org/W1987041229","https://openalex.org/W1990842129","https://openalex.org/W2000693765","https://openalex.org/W2020654481","https://openalex.org/W2048346987","https://openalex.org/W2053352141","https://openalex.org/W2061766512","https://openalex.org/W2075725245","https://openalex.org/W2079546021","https://openalex.org/W2081234638","https://openalex.org/W2082989212","https://openalex.org/W2086791741","https://openalex.org/W4230789310","https://openalex.org/W4299507953","https://openalex.org/W6601859328"],"related_works":["https://openalex.org/W2037182962","https://openalex.org/W2140910281","https://openalex.org/W2979791217","https://openalex.org/W2554934382","https://openalex.org/W1980957997","https://openalex.org/W2185621195","https://openalex.org/W1992891966","https://openalex.org/W1975498499","https://openalex.org/W2023804741","https://openalex.org/W1582458856"],"abstract_inverted_index":{"Glaucoma":[0],"is":[1],"the":[2,9,37,41,46],"leading":[3],"irreversible":[4],"cause":[5],"of":[6,31,48],"blindness":[7],"in":[8,23,51],"world.":[10],"We":[11,43],"are":[12],"developing":[13],"a":[14,20,24,32],"new":[15],"image-guidance":[16,35],"system":[17,29],"to":[18],"deliver":[19],"neuroprotective":[21],"drug":[22],"controlled":[25],"release":[26],"nanosponge.":[27],"The":[28],"consists":[30],"magnetically":[33],"tracked":[34],"system,":[36],"nanosponge":[38],"material":[39],"and":[40,54],"drug.":[42],"have":[44],"characterized":[45],"performance":[47],"each":[49],"aspect":[50],"phantoms,":[52],"animals":[53],"ex-vivo":[55],"human":[56],"tissue.":[57]},"counts_by_year":[{"year":2018,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}