{"id":"https://openalex.org/W1976301557","doi":"https://doi.org/10.1109/embc.2013.6610376","title":"Microfabricated device for co-culture of sympathetic neuron and iPS-derived cardiomyocytes","display_name":"Microfabricated device for co-culture of sympathetic neuron and iPS-derived cardiomyocytes","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W1976301557","doi":"https://doi.org/10.1109/embc.2013.6610376","mag":"1976301557","pmid":"https://pubmed.ncbi.nlm.nih.gov/24110563"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2013.6610376","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610376","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111767110","display_name":"Akimasa Takeuchi","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akimasa Takeuchi","raw_affiliation_strings":["Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan","Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan"],"affiliations":[{"raw_affiliation_string":"Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090447356","display_name":"Kenta Shimba","orcid":"https://orcid.org/0000-0003-1156-260X"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenta Shimba","raw_affiliation_strings":["Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan","Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan"],"affiliations":[{"raw_affiliation_string":"Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033654965","display_name":"Yuzo Takayama","orcid":"https://orcid.org/0000-0002-6382-8767"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuzo Takayama","raw_affiliation_strings":["Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan","Grad School of Information Sci. and Tech., Univ of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Grad School of Information Sci. and Tech., Univ of Tokyo, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108832608","display_name":"Kiyoshi Kotani","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Kotani","raw_affiliation_strings":["Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan","Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan"],"affiliations":[{"raw_affiliation_string":"Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066119014","display_name":"Jong-Kook Lee","orcid":"https://orcid.org/0000-0001-9053-7781"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"Osaka University","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jong-Kook Lee","raw_affiliation_strings":["Department of Cardiovascular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","Dept. of Cardiovascular Regenerative Med., Osaka Univ., Suita, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Dept. of Cardiovascular Regenerative Med., Osaka Univ., Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040349953","display_name":"Makoto Noshiro","orcid":null},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Noshiro","raw_affiliation_strings":["Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan","Kitasato University,Sagamihara,Japan"],"affiliations":[{"raw_affiliation_string":"Kitasato University, Minami-ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"Kitasato University,Sagamihara,Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032635092","display_name":"Yasuhiko Jimbo","orcid":"https://orcid.org/0009-0004-6005-5043"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Jimbo","raw_affiliation_strings":["Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan","Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan"],"affiliations":[{"raw_affiliation_string":"Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Grad. Sch. of Frontier Sci., Univ. of Tokyo, Kashiwa, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5111767110"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":0.1377,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.45713355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2013","issue":null,"first_page":"3817","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multielectrode-array","display_name":"Multielectrode array","score":0.84141606092453},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.6566997766494751},{"id":"https://openalex.org/keywords/superior-cervical-ganglion","display_name":"Superior cervical ganglion","score":0.5809497833251953},{"id":"https://openalex.org/keywords/microfabrication","display_name":"Microfabrication","score":0.5600834488868713},{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.5227682590484619},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.513361394405365},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4760042130947113},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.4270305633544922},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4029378294944763},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3469039797782898},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.32515573501586914},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23476696014404297},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20265841484069824},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.20103546977043152},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.16176486015319824},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.1595434844493866}],"concepts":[{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.84141606092453},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6566997766494751},{"id":"https://openalex.org/C2778993773","wikidata":"https://www.wikidata.org/wiki/Q1493493","display_name":"Superior cervical ganglion","level":2,"score":0.5809497833251953},{"id":"https://openalex.org/C527607","wikidata":"https://www.wikidata.org/wiki/Q175538","display_name":"Microfabrication","level":4,"score":0.5600834488868713},{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.5227682590484619},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.513361394405365},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4760042130947113},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4270305633544922},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4029378294944763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3469039797782898},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32515573501586914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23476696014404297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20265841484069824},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.20103546977043152},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.16176486015319824},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1595434844493866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017783","descriptor_name":"Superior Cervical Ganglion","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017783","descriptor_name":"Superior Cervical Ganglion","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017783","descriptor_name":"Superior Cervical Ganglion","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055616","descriptor_name":"Microtechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055616","descriptor_name":"Microtechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055616","descriptor_name":"Microtechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2013.6610376","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610376","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:24110563","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24110563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2042742190","https://openalex.org/W2046165746","https://openalex.org/W2063271884","https://openalex.org/W2076023125","https://openalex.org/W2087754208","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2157485677","https://openalex.org/W4251197476"],"related_works":["https://openalex.org/W2364669607","https://openalex.org/W1988115803","https://openalex.org/W1974387788","https://openalex.org/W2061877343","https://openalex.org/W2028205923","https://openalex.org/W2092214915","https://openalex.org/W2381760774","https://openalex.org/W2037345099","https://openalex.org/W4386697944","https://openalex.org/W2768056422"],"abstract_inverted_index":{"Induced":[0],"pluripotent":[1],"stem":[2],"(iPS)":[3],"cell-derived":[4],"cardiomyocytes":[5],"(iPS-CMs)":[6],"has":[7],"been":[8],"expected":[9],"as":[10,94],"a":[11,40,56,60,75,144],"cell":[12],"source":[13],"for":[14,42,157],"therapy":[15],"of":[16,27,44,55,101,113,120,126,142,162],"serious":[17],"heart":[18],"failure.":[19],"However,":[20],"it":[21],"is":[22,29],"unclear":[23],"whether":[24],"the":[25,32,102,106,111,114,127,134,140,151,159],"function":[26],"iPS-CMs":[28,48,73,107,121,163],"modulated":[30],"by":[31,96,164],"host":[33],"sympathetic":[34,45,166],"nervous":[35],"system.":[36],"Here":[37],"we":[38],"developed":[39],"device":[41,53,153],"co-culture":[43],"neurons":[46,69,91,104],"and":[47,59,92,105],"using":[49],"microfabrication":[50],"technique.":[51],"The":[52,64,117],"consisted":[54],"culture":[57],"chamber":[58],"microelectrode-array":[61],"(MEA)":[62],"substrate.":[63,116],"superior":[65],"cervical":[66],"ganglion":[67],"(SCG)":[68],"were":[70,87,108,137],"co-cultured":[71,128],"with":[72],"in":[74,133,139],"microfabricated":[76,152],"device,":[77],"which":[78],"had":[79],"multiple":[80],"compartments.":[81],"Several":[82],"days":[83],"after":[84,123],"seeding,":[85],"synapses":[86],"formed":[88],"between":[89],"SCG":[90,103,129],"iPS-CMs,":[93],"confirmed":[95],"immunostaining.":[97],"Spontaneous":[98],"electrical":[99,124],"activities":[100],"observed":[109],"from":[110],"electrode":[112],"MEA":[115],"beat":[118,135],"rate":[119,136],"increased":[122],"stimulation":[125],"neurons.":[130,167],"Such":[131],"changes":[132],"prevented":[138],"presence":[141],"propranolol,":[143],"\u03b2-adrenoreceptor":[145],"antagonist.":[146],"These":[147],"results":[148],"suggest":[149],"that":[150],"will":[154],"be":[155],"utilized":[156],"studying":[158],"functional":[160],"modulation":[161],"connected":[165]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
