{"id":"https://openalex.org/W1982598854","doi":"https://doi.org/10.1109/embc.2013.6610345","title":"A new quantitative approach for estimating bone cell connections from nano-CT images","display_name":"A new quantitative approach for estimating bone cell connections from nano-CT images","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W1982598854","doi":"https://doi.org/10.1109/embc.2013.6610345","mag":"1982598854","pmid":"https://pubmed.ncbi.nlm.nih.gov/24110532"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2013.6610345","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610345","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100882654","display_name":"Pei Dong","orcid":"https://orcid.org/0000-0002-7204-0621"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pei Dong","raw_affiliation_strings":["X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","CREATIS, Univ. de Lyon, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","institution_ids":["https://openalex.org/I2801997478"]},{"raw_affiliation_string":"CREATIS, Univ. de Lyon, Villeurbanne, France","institution_ids":["https://openalex.org/I4210138704","https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063462712","display_name":"Alexandra Pacureanu","orcid":"https://orcid.org/0000-0003-2306-7040"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandra Pacureanu","raw_affiliation_strings":["X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","CREATIS, Univ. de Lyon, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","institution_ids":["https://openalex.org/I2801997478"]},{"raw_affiliation_string":"CREATIS, Univ. de Lyon, Villeurbanne, France","institution_ids":["https://openalex.org/I4210138704","https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032634346","display_name":"Mar\u00eda A. Zuluaga","orcid":"https://orcid.org/0000-0002-1147-766X"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maria A. Zuluaga","raw_affiliation_strings":["X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","CREATIS, Univ. de Lyon, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","institution_ids":["https://openalex.org/I2801997478"]},{"raw_affiliation_string":"CREATIS, Univ. de Lyon, Villeurbanne, France","institution_ids":["https://openalex.org/I4210138704","https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112381937","display_name":"C\u00e9cile Olivier","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cecile Olivier","raw_affiliation_strings":["X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","CREATIS, Univ. de Lyon, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","institution_ids":["https://openalex.org/I2801997478"]},{"raw_affiliation_string":"CREATIS, Univ. de Lyon, Villeurbanne, France","institution_ids":["https://openalex.org/I4210138704","https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060965906","display_name":"Fr\u00e9d\u00e9rique Frouin","orcid":"https://orcid.org/0000-0002-7288-1543"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frederique Frouin","raw_affiliation_strings":["UMPC Univ Paris 6, Laboratoire d'Imagerie Fonctionnelle, Paris, France","CREATIS, Univ. de Lyon, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMPC Univ Paris 6, Laboratoire d'Imagerie Fonctionnelle, Paris, France","institution_ids":["https://openalex.org/I39804081"]},{"raw_affiliation_string":"CREATIS, Univ. de Lyon, Villeurbanne, France","institution_ids":["https://openalex.org/I4210138704","https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047275182","display_name":"Quentin Grimal","orcid":"https://orcid.org/0000-0001-9041-8176"},"institutions":[{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Quentin Grimal","raw_affiliation_strings":["UMPC Univ Paris 6, Laboratoire d'Imagerie Param\u00e9trique, Paris, France","Lab. d'Imagerie Parametrique, UMPC Univ. Paris 6, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMPC Univ Paris 6, Laboratoire d'Imagerie Param\u00e9trique, Paris, France","institution_ids":["https://openalex.org/I39804081"]},{"raw_affiliation_string":"Lab. d'Imagerie Parametrique, UMPC Univ. Paris 6, Paris, France","institution_ids":["https://openalex.org/I39804081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075496055","display_name":"Fran\u00e7oise Peyrin","orcid":"https://orcid.org/0000-0002-1988-3435"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]},{"id":"https://openalex.org/I4210138704","display_name":"Centre de Recherche en Acquisition et Traitement de l'Image pour la Sant\u00e9","ror":"https://ror.org/03smk3872","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210095849","https://openalex.org/I4210100596","https://openalex.org/I4210105738","https://openalex.org/I4210138704","https://openalex.org/I4210159245","https://openalex.org/I4405259976","https://openalex.org/I48430043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francoise Peyrin","raw_affiliation_strings":["X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","CREATIS, Univ. de Lyon, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"X-Ray Imaging Group, European Synchrotron Radiation Facility, Grenoble, France","institution_ids":["https://openalex.org/I2801997478"]},{"raw_affiliation_string":"CREATIS, Univ. de Lyon, Villeurbanne, France","institution_ids":["https://openalex.org/I4210138704","https://openalex.org/I100532134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7581,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70389249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2013","issue":null,"first_page":"3694","last_page":"3697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9821000099182129,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocyte","display_name":"Osteocyte","score":0.9154633283615112},{"id":"https://openalex.org/keywords/bone-canaliculus","display_name":"Bone canaliculus","score":0.8468589782714844},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6153052449226379},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5252246856689453},{"id":"https://openalex.org/keywords/cortical-bone","display_name":"Cortical bone","score":0.4971018135547638},{"id":"https://openalex.org/keywords/bounding-overwatch","display_name":"Bounding overwatch","score":0.4952761232852936},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49259477853775024},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.45751115679740906},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.425011545419693},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4248700737953186},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.42450448870658875},{"id":"https://openalex.org/keywords/testbed","display_name":"Testbed","score":0.42302989959716797},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3470509350299835},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.32156234979629517},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1990571916103363},{"id":"https://openalex.org/keywords/osteoblast","display_name":"Osteoblast","score":0.13764098286628723},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1314832866191864}],"concepts":[{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.9154633283615112},{"id":"https://openalex.org/C94033540","wikidata":"https://www.wikidata.org/wiki/Q5746981","display_name":"Bone canaliculus","level":2,"score":0.8468589782714844},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6153052449226379},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5252246856689453},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.4971018135547638},{"id":"https://openalex.org/C63584917","wikidata":"https://www.wikidata.org/wiki/Q333286","display_name":"Bounding overwatch","level":2,"score":0.4952761232852936},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49259477853775024},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.45751115679740906},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.425011545419693},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4248700737953186},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.42450448870658875},{"id":"https://openalex.org/C31395832","wikidata":"https://www.wikidata.org/wiki/Q1318674","display_name":"Testbed","level":2,"score":0.42302989959716797},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3470509350299835},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32156234979629517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1990571916103363},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.13764098286628723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1314832866191864},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017356","descriptor_name":"Synchrotrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017356","descriptor_name":"Synchrotrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017356","descriptor_name":"Synchrotrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc.2013.6610345","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610345","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:24110532","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24110532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:HAL:hal-00872770v1","is_oa":false,"landing_page_url":"https://hal.science/hal-00872770","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2013, Jul 2013, Osaka, Japan. pp.3694 - 3697, ⟨10.1109/EMBC.2013.6610345⟩","raw_type":"Conference papers"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1415499","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1415499/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)     pp. 3694-3697.   (2013)      ","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320326804","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63"},{"id":"https://openalex.org/F4320331419","display_name":"LabEx PRIMES","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W118271503","https://openalex.org/W1676075656","https://openalex.org/W2002453791","https://openalex.org/W2017866130","https://openalex.org/W2019582558","https://openalex.org/W2061832930","https://openalex.org/W2072959331","https://openalex.org/W2099934586","https://openalex.org/W2108678668","https://openalex.org/W2113760608","https://openalex.org/W2150421312","https://openalex.org/W2157419160","https://openalex.org/W2164741953","https://openalex.org/W2165311836","https://openalex.org/W4235309145","https://openalex.org/W6604949310"],"related_works":["https://openalex.org/W2653464437","https://openalex.org/W1186154781","https://openalex.org/W4238836232","https://openalex.org/W3148400793","https://openalex.org/W3198622471","https://openalex.org/W1989320818","https://openalex.org/W2946803132","https://openalex.org/W1982669331","https://openalex.org/W2638158074","https://openalex.org/W4220738105"],"abstract_inverted_index":{"Recent":[0],"works":[1],"highlighted":[2],"the":[3,7,27,37,53,64,72,80,98,108,148],"crucial":[4],"role":[5],"of":[6,15,17,29,39,82,128,142],"osteocyte":[8,18],"system":[9],"in":[10,85,97],"bone":[11,30,83],"fragility.":[12],"The":[13,117],"number":[14],"canaliculi":[16],"lacuna":[19,96],"(Lc.NCa)":[20],"is":[21,58,110,145],"an":[22,75],"important":[23],"parameter":[24],"that":[25],"reflects":[26],"functionality":[28],"tissue,":[31],"but":[32],"rarely":[33],"reported":[34],"due":[35],"to":[36,62,78,123],"limitations":[38],"current":[40],"microscopy":[41],"techniques,":[42],"and":[43,93],"only":[44],"assessed":[45],"from":[46],"2D":[47],"histology":[48],"sections.":[49],"Previously,":[50],"we":[51,69],"showed":[52],"Synchrotron":[54],"Radiation":[55],"nanotomography":[56],"(SR-nanoCT)":[57],"a":[59,103,124,140],"promising":[60],"technique":[61],"image":[63,127],"3D":[65,114,125],"lacunar-canalicular":[66],"network.":[67,99],"Here":[68],"present,":[70],"for":[71],"first":[73,91],"time,":[74],"automatic":[76],"method":[77,90,119],"quantify":[79],"connectivity":[81],"cells":[84],"3D.":[86],"After":[87],"segmentation,":[88],"our":[89],"separates":[92],"labels":[94],"each":[95],"Then,":[100],"by":[101],"creating":[102],"bounding":[104],"surface":[105],"around":[106],"lacuna,":[107],"Lc.NCa":[109],"calculated":[111],"through":[112],"estimating":[113],"topological":[115],"parameters.":[116],"proposed":[118],"was":[120],"successfully":[121],"applied":[122],"SR-nanoCT":[126],"cortical":[129],"femoral":[130],"bone.":[131],"Statistical":[132],"results":[133],"on":[134],"165":[135],"lacunae":[136],"are":[137],"reported,":[138],"showing":[139],"mean":[141],"51,":[143],"which":[144],"consistent":[146],"with":[147],"literature.":[149]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}