{"id":"https://openalex.org/W2014233510","doi":"https://doi.org/10.1109/embc.2012.6346797","title":"Consideration on parameter determination of a new model describing dynamic vagal heart rate control in rats","display_name":"Consideration on parameter determination of a new model describing dynamic vagal heart rate control in rats","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2014233510","doi":"https://doi.org/10.1109/embc.2012.6346797","mag":"2014233510","pmid":"https://pubmed.ncbi.nlm.nih.gov/23366758"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6346797","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346797","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041063008","display_name":"Toru Kawada","orcid":"https://orcid.org/0000-0002-4429-1802"},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Kawada","raw_affiliation_strings":["Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan. torukawa@ri.ncvc.go.jp","Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan. torukawa@ri.ncvc.go.jp","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029270490","display_name":"Kazunori Uemura","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Uemura","raw_affiliation_strings":["Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023309521","display_name":"Shuji Shimizu","orcid":"https://orcid.org/0009-0002-8904-8504"},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Shimizu","raw_affiliation_strings":["Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110054179","display_name":"A. Kamiya","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A. Kamiya","raw_affiliation_strings":["Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101997077","display_name":"Michael J. Turner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. J. Turner","raw_affiliation_strings":["Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]},{"raw_affiliation_string":"Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan","institution_ids":["https://openalex.org/I4210111404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080909826","display_name":"Masaki Mizuno","orcid":"https://orcid.org/0000-0003-4455-8084"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"M. Mizuno","raw_affiliation_strings":["Department of Health Care Sciences, University of Texas Southwestern Medical Centre, Dallas, TX, USA","Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Care Sciences, University of Texas Southwestern Medical Centre, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007483946","display_name":"Kenji Sunagawa","orcid":"https://orcid.org/0000-0003-0365-4619"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Sunagawa","raw_affiliation_strings":["Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110075311","display_name":"Masaru Sugimachi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Sugimachi","raw_affiliation_strings":["Natl Cardio Center Research Inst, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natl Cardio Center Research Inst, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"260","issue":null,"first_page":"3809","last_page":"3812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transfer-function","display_name":"Transfer function","score":0.783183217048645},{"id":"https://openalex.org/keywords/frequency-domain","display_name":"Frequency domain","score":0.6118277907371521},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.5186390280723572},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5087903141975403},{"id":"https://openalex.org/keywords/frequency-response","display_name":"Frequency response","score":0.5080780982971191},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.494172602891922},{"id":"https://openalex.org/keywords/time-domain","display_name":"Time domain","score":0.43398359417915344},{"id":"https://openalex.org/keywords/regression-analysis","display_name":"Regression analysis","score":0.43367016315460205},{"id":"https://openalex.org/keywords/bode-plot","display_name":"Bode plot","score":0.42678046226501465},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.24498870968818665},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.23076379299163818},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.19987553358078003}],"concepts":[{"id":"https://openalex.org/C81299745","wikidata":"https://www.wikidata.org/wiki/Q334269","display_name":"Transfer function","level":2,"score":0.783183217048645},{"id":"https://openalex.org/C19118579","wikidata":"https://www.wikidata.org/wiki/Q786423","display_name":"Frequency domain","level":2,"score":0.6118277907371521},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.5186390280723572},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5087903141975403},{"id":"https://openalex.org/C8590192","wikidata":"https://www.wikidata.org/wiki/Q1054694","display_name":"Frequency response","level":2,"score":0.5080780982971191},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.494172602891922},{"id":"https://openalex.org/C103824480","wikidata":"https://www.wikidata.org/wiki/Q185889","display_name":"Time domain","level":2,"score":0.43398359417915344},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.43367016315460205},{"id":"https://openalex.org/C92487091","wikidata":"https://www.wikidata.org/wiki/Q245627","display_name":"Bode plot","level":3,"score":0.42678046226501465},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.24498870968818665},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.23076379299163818},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19987553358078003},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6346797","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346797","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23366758","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23366758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W3937360","https://openalex.org/W1519946308","https://openalex.org/W1999629141","https://openalex.org/W2096601585","https://openalex.org/W2101641500","https://openalex.org/W2167985345","https://openalex.org/W2408343681"],"related_works":["https://openalex.org/W18072180","https://openalex.org/W4285137703","https://openalex.org/W2020129703","https://openalex.org/W2057655484","https://openalex.org/W2129868975","https://openalex.org/W1981447901","https://openalex.org/W2130342816","https://openalex.org/W3021238503","https://openalex.org/W2755263308","https://openalex.org/W3005229678"],"abstract_inverted_index":{"The":[0,85,126,141],"dynamic":[1,199],"characteristics":[2],"of":[3,32,37,73,87,94,100,119,128,147,169,183,192],"vagal":[4,34,80,113,204],"heart":[5,39,109,200],"rate":[6,40,110,201],"control":[7,41],"can":[8],"be":[9,28],"approximated":[10],"by":[11],"a":[12,45,59,64,145,167,193],"first-order":[13],"low-pass":[14],"filter":[15],"with":[16],"pure":[17],"dead":[18],"time":[19,139],"in":[20,42,49,78,83,96,134,206],"rabbits.":[21],"However,":[22],"this":[23],"model":[24,61,185,195],"may":[25],"not":[26],"necessarily":[27],"the":[29,33,38,50,70,74,79,88,92,101,117,120,136,155,163,173,190,198],"best":[30],"approximation":[31],"transfer":[35,81,130,175],"function":[36,82,176],"rats,":[43],"because":[44],"flatter":[46,71],"portion":[47,72],"exists":[48],"gain":[51,66,75],"plot":[52,76],"above":[53],"approximately":[54],"0.3":[55],"Hz.":[56,181],"We":[57],"developed":[58],"new":[60,89,194],"that":[62,149,171],"includes":[63],"frequency-independent":[65],"term":[67,90],"to":[68,112,124,153,179,196,203],"reproduce":[69,154],"seen":[77],"rats.":[84,207],"inclusion":[86],"increased":[91],"coefficient":[93],"determination":[95],"an":[97],"external":[98],"validation":[99],"linear":[102],"regression":[103,121],"relationship":[104],"between":[105],"measured":[106],"and":[107,115,138],"predicted":[108],"responses":[111],"stimulation,":[114],"made":[116],"slope":[118],"line":[122],"closer":[123],"unity.":[125],"parameters":[127,148,170,186],"mathematical":[129],"functions":[131],"were":[132],"determined":[133],"both":[135],"frequency":[137],"domains.":[140],"frequency-domain":[142,174],"fitting":[143,165],"provided":[144,166],"set":[146,168],"was":[150,187],"also":[151],"able":[152],"time-domain":[156,164],"step":[157],"response":[158,202],"reasonably":[159],"well.":[160],"In":[161],"contrast,":[162],"reproduced":[172],"only":[177],"up":[178],"0.2":[180],"Determination":[182],"proper":[184],"crucial":[188],"for":[189],"development":[191],"describe":[197],"stimulation":[205]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}