{"id":"https://openalex.org/W2110259783","doi":"https://doi.org/10.1109/cec.2003.1299591","title":"Improvement of clustal-derived sequence alignments with evolutionary algorithms","display_name":"Improvement of clustal-derived sequence alignments with evolutionary algorithms","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2110259783","doi":"https://doi.org/10.1109/cec.2003.1299591","mag":"2110259783"},"language":"en","primary_location":{"id":"doi:10.1109/cec.2003.1299591","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2003.1299591","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 2003 Congress on Evolutionary Computation, 2003. CEC '03.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079781801","display_name":"Ren\u00e9 Thomsen","orcid":null},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"R. Thomsen","raw_affiliation_strings":["Dept. of Comput. Sci., Aarhus Univ., Denmark","Department of Computer Science, University of Aarhus, Aarhus, Denmark"],"affiliations":[{"raw_affiliation_string":"Dept. of Comput. Sci., Aarhus Univ., Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Department of Computer Science, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014941588","display_name":"Gary B. Fogel","orcid":"https://orcid.org/0000-0003-2848-3043"},"institutions":[{"id":"https://openalex.org/I4210110140","display_name":"Natural Selection (United States)","ror":"https://ror.org/024es8b17","country_code":"US","type":"company","lineage":["https://openalex.org/I4210110140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.B. Fogel","raw_affiliation_strings":["Natural Selection, Inc., La Jolla, CA, USA"],"affiliations":[{"raw_affiliation_string":"Natural Selection, Inc., La Jolla, CA, USA","institution_ids":["https://openalex.org/I4210110140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032133436","display_name":"Thiemo Krink","orcid":null},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"T. Krink","raw_affiliation_strings":["Department of Computer Science, University of Aarhus, Aarhus, Denmark"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Aarhus, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079781801"],"corresponding_institution_ids":["https://openalex.org/I204337017"],"apc_list":null,"apc_paid":null,"fwci":0.4575,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.61845253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"312","last_page":"319 Vol.1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6681350469589233},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5566681027412415},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4886167645454407},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.4429376721382141},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28932639956474304},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11875960230827332},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0763254165649414}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6681350469589233},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5566681027412415},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4886167645454407},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.4429376721382141},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28932639956474304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11875960230827332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0763254165649414}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/cec.2003.1299591","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cec.2003.1299591","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 2003 Congress on Evolutionary Computation, 2003. CEC '03.","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.70.1239","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.70.1239","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.natural-selection.com/Library/2003/03CEC_Improvement_Clustal.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/2f382750-8d33-11dc-bee9-02004c4f4f50","is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/2f382750-8d33-11dc-bee9-02004c4f4f50","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thomsen, R, Fogel, G B & Krink, T 2003, Improvement of Clustal-Derived Sequence Alignments with Evolutionary Algorithms. in 2003 Congress on Evolutionary Computation. IEEE Press, pp. 1499-1507.","raw_type":"bookPart"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1484713061","https://openalex.org/W1507099015","https://openalex.org/W1693576464","https://openalex.org/W1702013544","https://openalex.org/W1969153299","https://openalex.org/W2002638840","https://openalex.org/W2044164898","https://openalex.org/W2047923658","https://openalex.org/W2097382368","https://openalex.org/W2102941368","https://openalex.org/W2106882534","https://openalex.org/W2129437793","https://openalex.org/W2143210482","https://openalex.org/W2163860567","https://openalex.org/W6637200175"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2051487156","https://openalex.org/W2073681303","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2384897607"],"abstract_inverted_index":{"Multiple":[0],"sequence":[1,61],"alignment":[2,34,50,65,73,122],"(MSA)":[3],"is":[4],"a":[5],"central":[6],"problem":[7],"in":[8,25,121,124],"bioinformatics.":[9],"In":[10],"this":[11],"study,":[12],"we":[13],"extended":[14],"previous":[15],"efforts":[16],"using":[17,79],"evolutionary":[18],"algorithms":[19],"(EAs)":[20],"for":[21],"MSA.":[22],"Candidate":[23],"solutions":[24],"the":[26,32,57,76,80,88,95,101,106,127],"initial":[27],"population":[28],"were":[29,52,67],"derived":[30],"from":[31,75],"well-known":[33],"program":[35],"Clustal":[36,98],"X.":[37,99],"Evolutionary":[38],"computation":[39],"was":[40],"then":[41],"used":[42,108],"to":[43,71,90,114],"evolve":[44],"increasingly":[45],"appropriate":[46],"solutions.":[47],"Three":[48],"new":[49],"operators":[51],"introduced":[53],"and":[54],"tested":[55],"within":[56],"framework":[58],"of":[59,97,126],"protein":[60],"alignment.":[62],"Statistics":[63],"on":[64],"quality":[66,123],"generated":[68],"with":[69,119],"respect":[70],"selected":[72],"benchmarks":[74],"BAliBASE":[77,128],"database":[78],"BLOSUM":[81],"62":[82],"substitution":[83],"matrix.":[84],"Our":[85],"results":[86,96,103],"indicate":[87],"degree":[89],"which":[91],"EAs":[92],"can":[93],"enhance":[94],"Moreover,":[100],"experimental":[102],"show":[104],"that":[105],"commonly":[107],"sum-of-pairs":[109,129],"scoring":[110,117],"scheme":[111],"sometimes":[112],"fails":[113],"correlate":[115],"higher":[116],"alignments":[118],"increase":[120],"terms":[125],"score.":[130]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}