{"id":"https://openalex.org/W1955311861","doi":"https://doi.org/10.1109/cca.2015.7320824","title":"Control systems technology in the advanced manufacturing of biologic drugs","display_name":"Control systems technology in the advanced manufacturing of biologic drugs","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W1955311861","doi":"https://doi.org/10.1109/cca.2015.7320824","mag":"1955311861"},"language":"en","primary_location":{"id":"doi:10.1109/cca.2015.7320824","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2015.7320824","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE Conference on Control Applications (CCA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015789942","display_name":"Amos E. Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amos E. Lu","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, USA","Massachusetts Institute of Technology, Cambridge, MA. 02139, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA. 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042465949","display_name":"Joel A. Paulson","orcid":"https://orcid.org/0000-0002-1518-7985"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel A. Paulson","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, USA","Massachusetts Institute of Technology, Cambridge, MA. 02139, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA. 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062638543","display_name":"Nicholas J. Mozdzierz","orcid":"https://orcid.org/0000-0002-2078-5883"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Mozdzierz","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, USA","Massachusetts Institute of Technology, Cambridge, MA. 02139, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA. 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045091582","display_name":"Alan Stockdale","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Stockdale","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, USA","Massachusetts Institute of Technology, Cambridge, MA. 02139, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA. 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024222019","display_name":"Ashlee N. Ford Versypt","orcid":"https://orcid.org/0000-0001-9059-5703"},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I2800216316","display_name":"Oklahoma State University System","ror":"https://ror.org/045ntgf29","country_code":"US","type":"education","lineage":["https://openalex.org/I2800216316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashlee N. Ford Versypt","raw_affiliation_strings":["Oklahoma State University System, Stillwater, OK, US","Oklahoma State University, Stillwater, OK 74078 USA"],"affiliations":[{"raw_affiliation_string":"Oklahoma State University System, Stillwater, OK, US","institution_ids":["https://openalex.org/I2800216316"]},{"raw_affiliation_string":"Oklahoma State University, Stillwater, OK 74078 USA","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032296327","display_name":"Kerry R. Love","orcid":"https://orcid.org/0000-0003-1840-3820"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerry R. Love","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, USA","Massachusetts Institute of Technology, Cambridge, MA. 02139, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA. 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001076999","display_name":"J. Christopher Love","orcid":"https://orcid.org/0000-0003-0921-3144"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Christopher Love","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, USA","Massachusetts Institute of Technology, Cambridge, MA. 02139, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA. 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083684552","display_name":"Richard D. Braatz","orcid":"https://orcid.org/0000-0003-4304-3484"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Braatz","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA, USA","Massachusetts Institute of Technology, Cambridge, MA. 02139, USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA. 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5015789942"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":0.8752,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73134807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1505","last_page":"1515"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9435999989509583,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomanufacturing","display_name":"Biomanufacturing","score":0.9914364814758301},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.634918749332428},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4683762192726135},{"id":"https://openalex.org/keywords/manufacturing-engineering","display_name":"Manufacturing engineering","score":0.45255106687545776},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.4249735474586487},{"id":"https://openalex.org/keywords/systems-engineering","display_name":"Systems engineering","score":0.40881070494651794},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.39982813596725464},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.10772010684013367},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.10699352622032166},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1035534143447876}],"concepts":[{"id":"https://openalex.org/C2775893736","wikidata":"https://www.wikidata.org/wiki/Q25324110","display_name":"Biomanufacturing","level":2,"score":0.9914364814758301},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.634918749332428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4683762192726135},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.45255106687545776},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4249735474586487},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.40881070494651794},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.39982813596725464},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10772010684013367},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.10699352622032166},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1035534143447876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cca.2015.7320824","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cca.2015.7320824","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE Conference on Control Applications (CCA)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.49000000953674316,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W193880938","https://openalex.org/W257186868","https://openalex.org/W610861889","https://openalex.org/W1557141846","https://openalex.org/W1576895289","https://openalex.org/W1583202152","https://openalex.org/W1605182176","https://openalex.org/W1965846018","https://openalex.org/W1974852879","https://openalex.org/W1979894627","https://openalex.org/W1986987637","https://openalex.org/W1990399343","https://openalex.org/W1992816819","https://openalex.org/W1993337558","https://openalex.org/W1996059448","https://openalex.org/W1997804429","https://openalex.org/W2012849114","https://openalex.org/W2023816368","https://openalex.org/W2046253206","https://openalex.org/W2047188276","https://openalex.org/W2051187049","https://openalex.org/W2052859646","https://openalex.org/W2059632291","https://openalex.org/W2060506093","https://openalex.org/W2071646337","https://openalex.org/W2071694863","https://openalex.org/W2077285487","https://openalex.org/W2081572530","https://openalex.org/W2082193830","https://openalex.org/W2085688559","https://openalex.org/W2089718635","https://openalex.org/W2093339910","https://openalex.org/W2094487669","https://openalex.org/W2106641975","https://openalex.org/W2117453669","https://openalex.org/W2126105956","https://openalex.org/W2131215809","https://openalex.org/W2135449205","https://openalex.org/W2137018402","https://openalex.org/W2155196267","https://openalex.org/W2160532357","https://openalex.org/W2167240901","https://openalex.org/W2167446247","https://openalex.org/W2284202824","https://openalex.org/W2354242643","https://openalex.org/W2796609086","https://openalex.org/W2917973694","https://openalex.org/W3004335124","https://openalex.org/W3018068659","https://openalex.org/W4206838542","https://openalex.org/W4233847460","https://openalex.org/W4239144056","https://openalex.org/W4242409626","https://openalex.org/W4250739342","https://openalex.org/W4301955916","https://openalex.org/W6607824675","https://openalex.org/W6629902501"],"related_works":["https://openalex.org/W4294877544","https://openalex.org/W2490890447","https://openalex.org/W1548847100","https://openalex.org/W3124031114","https://openalex.org/W4283782326","https://openalex.org/W4295442981","https://openalex.org/W4311759274","https://openalex.org/W4380032316","https://openalex.org/W2603195643","https://openalex.org/W2481254147"],"abstract_inverted_index":{"The":[0],"paper":[1],"focuses":[2],"on":[3,30],"systems":[4],"engineering":[5],"challenges":[6],"for":[7,64],"biomanufacturing,":[8],"as":[9],"exemplified":[10],"by":[11],"the":[12,21,37,47,65,69],"Integrated":[13],"and":[14,43,50,61,79,83,86],"Scalable":[15],"Cyto-Technology":[16],"(InSCyT)":[17],"bio-manufacturing":[18],"platform":[19],"under":[20],"Defense":[22],"Advanced":[23],"Research":[24],"Projects":[25],"Agency":[26],"(DARPA)":[27],"Biologically-derived":[28],"Medicines":[29],"Demand":[31],"(Bio-MOD)":[32],"program.":[33],"One":[34],"goal":[35],"of":[36,52],"project":[38],"is":[39],"to":[40,46],"apply":[41],"modeling":[42],"simulation":[44],"techniques":[45],"design,":[48],"control,":[49],"optimization":[51],"biomanufacturing":[53],"operations.":[54],"In":[55],"this":[56],"paper,":[57],"we":[58],"present":[59],"models":[60],"control":[62],"strategies":[63],"unit":[66],"operations":[67],"within":[68],"InSCyT":[70],"platform,":[71],"including":[72],"a":[73,84],"perfusion":[74],"bioreactor,":[75],"several":[76],"packed":[77],"bed":[78],"membrane":[80],"chromatography":[81],"steps,":[82],"conductivity-":[85],"pH-controlled":[87],"buffer":[88],"mixing":[89],"unit.":[90]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
