{"id":"https://openalex.org/W4407169858","doi":"https://doi.org/10.1109/cbs61689.2024.10860625","title":"Simulation of Epileptic Seizure Suppression through Extracellular Potassium Modulation","display_name":"Simulation of Epileptic Seizure Suppression through Extracellular Potassium Modulation","publication_year":2024,"publication_date":"2024-11-20","ids":{"openalex":"https://openalex.org/W4407169858","doi":"https://doi.org/10.1109/cbs61689.2024.10860625"},"language":"en","primary_location":{"id":"doi:10.1109/cbs61689.2024.10860625","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbs61689.2024.10860625","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Cyborg and Bionic Systems (CBS)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052413622","display_name":"Niccol\u00f2 Calcini","orcid":"https://orcid.org/0000-0001-9727-3571"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niccol\u00f2 Calcini","raw_affiliation_strings":["Maastricht University,Maastricht Centre for Systems Biology (MaCSBio),Maastricht,The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University,Maastricht Centre for Systems Biology (MaCSBio),Maastricht,The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116160500","display_name":"Vitalii Kyzym","orcid":null},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Vitalii Kyzym","raw_affiliation_strings":["Maastricht University,Maastricht Centre for Systems Biology (MaCSBio),Maastricht,The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University,Maastricht Centre for Systems Biology (MaCSBio),Maastricht,The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086274042","display_name":"Renaud Jolivet","orcid":"https://orcid.org/0000-0002-5167-0851"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Renaud B. Jolivet","raw_affiliation_strings":["Maastricht University,Maastricht Centre for Systems Biology (MaCSBio),Maastricht,The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University,Maastricht Centre for Systems Biology (MaCSBio),Maastricht,The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I34352273"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51180359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"143","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9724000096321106,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9433000087738037,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.6510598063468933},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.6492329239845276},{"id":"https://openalex.org/keywords/epileptic-seizure","display_name":"Epileptic seizure","score":0.5631346702575684},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4906705617904663},{"id":"https://openalex.org/keywords/modulation","display_name":"Modulation (music)","score":0.45543867349624634},{"id":"https://openalex.org/keywords/potassium","display_name":"Potassium","score":0.44513261318206787},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.26720309257507324},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.22038260102272034},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.19147884845733643},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18645703792572021},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1801663637161255},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.05162554979324341}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6510598063468933},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6492329239845276},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.5631346702575684},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4906705617904663},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.45543867349624634},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.44513261318206787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26720309257507324},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22038260102272034},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.19147884845733643},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18645703792572021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1801663637161255},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.05162554979324341},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cbs61689.2024.10860625","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbs61689.2024.10860625","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Conference on Cyborg and Bionic Systems (CBS)","raw_type":"proceedings-article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/c8c2115e-7767-435b-b4ae-6b5b4ac6870a","is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/c8c2115e-7767-435b-b4ae-6b5b4ac6870a","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Calcini, N, Kyzym, V & Jolivet, R B 2024, Simulation of Epileptic Seizure Suppression through Extracellular Potassium Modulation. in Proceedings of the 2024 IEEE International Conference on Cyborg and Bionic Systems, CBS 2024. IEEE, Proceedings of the IEEE International Conference on Cyborg and Bionic Systems, CBS, pp. 143-147, 2024 IEEE International Conference on Cyborg and Bionic Systems, CBS 2024, Nagoya, Japan, 20/11/24. https://doi.org/10.1109/CBS61689.2024.10860625","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.550000011920929}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1735445987","https://openalex.org/W1920696238","https://openalex.org/W1970117905","https://openalex.org/W1985940938","https://openalex.org/W2020216633","https://openalex.org/W2026864246","https://openalex.org/W2069231742","https://openalex.org/W2083252150","https://openalex.org/W2106342149","https://openalex.org/W2128491503","https://openalex.org/W2132317990","https://openalex.org/W2135629133","https://openalex.org/W2142181855","https://openalex.org/W2147270524","https://openalex.org/W2158334924","https://openalex.org/W2179178098","https://openalex.org/W2192126750","https://openalex.org/W2292013247","https://openalex.org/W2425728667","https://openalex.org/W2567632189","https://openalex.org/W2592011942","https://openalex.org/W2594644573","https://openalex.org/W2899494972","https://openalex.org/W2964650265","https://openalex.org/W2969331319","https://openalex.org/W3015095120","https://openalex.org/W3031797629","https://openalex.org/W3132572579","https://openalex.org/W3193369139","https://openalex.org/W4391465687","https://openalex.org/W4396853067","https://openalex.org/W6809998153"],"related_works":["https://openalex.org/W190756422","https://openalex.org/W2323677139","https://openalex.org/W2395385109","https://openalex.org/W2952941127","https://openalex.org/W750390717","https://openalex.org/W1986936937","https://openalex.org/W2125434199","https://openalex.org/W2773633178","https://openalex.org/W2048194780","https://openalex.org/W2363907062"],"abstract_inverted_index":{"Epilepsy,":[0],"a":[1,61,101],"disabling":[2],"condition":[3],"impacting":[4],"millions":[5],"globally,":[6],"remains":[7],"largely":[8],"refractory":[9],"to":[10,45,59,105],"standard":[11],"pharmacological":[12],"treatments":[13],"in":[14,110],"about":[15],"one":[16],"third":[17],"of":[18,26,68,84,100],"cases.":[19],"Current":[20],"alternative":[21],"strategies":[22],"include":[23],"surgical":[24],"resection":[25],"affected":[27,89],"tissue":[28],"or":[29],"invasive":[30],"neuromodulatory":[31],"techniques":[32],"like":[33],"deep":[34],"brain":[35],"stimulation,":[36],"though":[37],"these":[38],"methods":[39],"often":[40],"face":[41],"significant":[42],"limitations":[43],"due":[44],"their":[46],"non-specific":[47],"and":[48],"potentially":[49],"disruptive":[50],"nature.":[51],"In":[52],"this":[53],"study,":[54],"we":[55,73],"employed":[56],"network":[57,88],"simulations":[58,95],"explore":[60],"novel":[62],"approach":[63],"based":[64],"on":[65],"the":[66,82,97],"modulation":[67],"extracellular":[69,77],"ion":[70,108],"concentrations.":[71],"Specifically,":[72],"investigated":[74],"how":[75],"manipulating":[76],"potassium":[78,107],"concentration":[79],"could":[80],"influence":[81],"behavior":[83],"an":[85],"excitatory-inhibitory":[86],"neural":[87],"by":[90],"induced,":[91],"focal":[92],"epilepsy.":[93],"Our":[94],"demonstrate":[96],"potential":[98],"effectiveness":[99],"theoretical":[102],"device":[103],"designed":[104],"alter":[106],"concentrations":[109],"blocking":[111],"epileptic-like":[112],"activity":[113],"at":[114],"its":[115],"onset.":[116]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
