{"id":"https://openalex.org/W4412021382","doi":"https://doi.org/10.1109/cbms65348.2025.00115","title":"A Comparison of Open Source Deep Learning Based Models for Automatic Tumor Segmentation in Radiotherapy Planning of Glioblastoma Multiforme Adult Patients","display_name":"A Comparison of Open Source Deep Learning Based Models for Automatic Tumor Segmentation in Radiotherapy Planning of Glioblastoma Multiforme Adult Patients","publication_year":2025,"publication_date":"2025-06-18","ids":{"openalex":"https://openalex.org/W4412021382","doi":"https://doi.org/10.1109/cbms65348.2025.00115"},"language":"en","primary_location":{"id":"doi:10.1109/cbms65348.2025.00115","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms65348.2025.00115","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://upcommons.upc.edu/bitstreams/ffa5c9ed-db73-449e-95ce-a1652fdee0df/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Gloria Campos","orcid":"https://orcid.org/0009-0005-0330-2455"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gloria Campos","raw_affiliation_strings":["Universitat Polit&#x00E8;cnica de Val&#x00E8;ncia,Neurorehabilitation and Brain Research Group (NRHB),Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Universitat Polit&#x00E8;cnica de Val&#x00E8;ncia,Neurorehabilitation and Brain Research Group (NRHB),Valencia,Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028700235","display_name":"Mar\u00eda Beser\u2010Robles","orcid":"https://orcid.org/0000-0002-0072-5525"},"institutions":[{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Beser-Robles","raw_affiliation_strings":["Instituto de Investigaci&#x00F3;n Sanitaria La Fe,Biomedical Image Research Group (GIBI2),Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci&#x00F3;n Sanitaria La Fe,Biomedical Image Research Group (GIBI2),Valencia,Spain","institution_ids":["https://openalex.org/I4210166036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017017805","display_name":"Jaime Castell\u00e1-Malonda","orcid":"https://orcid.org/0000-0002-0887-8278"},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jaime Castell\u00e1-Malonda","raw_affiliation_strings":["Hospital Universitario y Polit&#x00E9;cnico de La Fe,Department of Radiology,Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Universitario y Polit&#x00E9;cnico de La Fe,Department of Radiology,Valencia,Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072387429","display_name":"Luis Mart\u00ed\u2010Bonmat\u00ed","orcid":"https://orcid.org/0000-0002-8234-010X"},"institutions":[{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Mart\u00ed-Bonmat\u00ed","raw_affiliation_strings":["Instituto de Investigaci&#x00F3;n Sanitaria La Fe,Biomedical Image Research Group (GIBI2),Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci&#x00F3;n Sanitaria La Fe,Biomedical Image Research Group (GIBI2),Valencia,Spain","institution_ids":["https://openalex.org/I4210166036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089265253","display_name":"Christian Mata","orcid":"https://orcid.org/0000-0003-4768-5062"},"institutions":[{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Christian Mata","raw_affiliation_strings":["Institute for Research and Innovation in Health (IRIS), Universitat Polit&#x00E8;cnica de Catalunya - BarcelonaTech (UPC),Barcelona,Spain"],"affiliations":[{"raw_affiliation_string":"Institute for Research and Innovation in Health (IRIS), Universitat Polit&#x00E8;cnica de Catalunya - BarcelonaTech (UPC),Barcelona,Spain","institution_ids":["https://openalex.org/I9617848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040081415","display_name":"M. Carles","orcid":"https://orcid.org/0000-0003-2401-8240"},"institutions":[{"id":"https://openalex.org/I4210166036","display_name":"Instituto de Investigaci\u00f3n Sanitaria La Fe","ror":"https://ror.org/05n7v5997","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Montserrat Carles","raw_affiliation_strings":["Instituto de Investigaci&#x00F3;n Sanitaria La Fe,Biomedical Image Research Group (GIBI2),Valencia,Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci&#x00F3;n Sanitaria La Fe,Biomedical Image Research Group (GIBI2),Valencia,Spain","institution_ids":["https://openalex.org/I4210166036"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20163737,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"535","last_page":"540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9642000198364258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9257000088691711,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.8251982927322388},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.6505327224731445},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5325110554695129},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5199138522148132},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4957524240016937},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.4497423768043518},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.43354111909866333},{"id":"https://openalex.org/keywords/open-source","display_name":"Open source","score":0.42990192770957947},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.32966500520706177},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.233200341463089},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.15923386812210083},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.07920306921005249}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.8251982927322388},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6505327224731445},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5325110554695129},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5199138522148132},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4957524240016937},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4497423768043518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43354111909866333},{"id":"https://openalex.org/C3018397939","wikidata":"https://www.wikidata.org/wiki/Q3644502","display_name":"Open source","level":3,"score":0.42990192770957947},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.32966500520706177},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.233200341463089},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15923386812210083},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.07920306921005249}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/cbms65348.2025.00115","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms65348.2025.00115","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"},{"id":"pmh:oai:upcommons.upc.edu:2117/446243","is_oa":true,"landing_page_url":"https://hdl.handle.net/2117/446243","pdf_url":"https://upcommons.upc.edu/bitstreams/ffa5c9ed-db73-449e-95ce-a1652fdee0df/download","source":{"id":"https://openalex.org/S4377196262","display_name":"UPCommons institutional repository (Universitat Polit\u00e8cnica de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I9617848","host_organization_name":"Universitat Polit\u00e8cnica de Catalunya","host_organization_lineage":["https://openalex.org/I9617848"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:upcommons.upc.edu:2117/446243","is_oa":true,"landing_page_url":"https://hdl.handle.net/2117/446243","pdf_url":"https://upcommons.upc.edu/bitstreams/ffa5c9ed-db73-449e-95ce-a1652fdee0df/download","source":{"id":"https://openalex.org/S4377196262","display_name":"UPCommons institutional repository (Universitat Polit\u00e8cnica de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I9617848","host_organization_name":"Universitat Polit\u00e8cnica de Catalunya","host_organization_lineage":["https://openalex.org/I9617848"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2744487609","display_name":null,"funder_award_id":"TRANSCAN-3","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3779662906","display_name":null,"funder_award_id":"00012","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G594548769","display_name":null,"funder_award_id":"AC23_1/00012","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412021382.pdf"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1565207862","https://openalex.org/W1901129140","https://openalex.org/W2026616100","https://openalex.org/W2106235379","https://openalex.org/W2584466409","https://openalex.org/W2963163009","https://openalex.org/W2968446587","https://openalex.org/W3014974815","https://openalex.org/W3031224726","https://openalex.org/W3112701542","https://openalex.org/W3138516171","https://openalex.org/W3146345129","https://openalex.org/W4205868820","https://openalex.org/W4221163766","https://openalex.org/W4226385270","https://openalex.org/W4280614820","https://openalex.org/W4282835921","https://openalex.org/W4283366563","https://openalex.org/W4287100534","https://openalex.org/W4307323201","https://openalex.org/W4308414511","https://openalex.org/W4310602522","https://openalex.org/W4312443924","https://openalex.org/W4319350678","https://openalex.org/W4384626308","https://openalex.org/W4385556479","https://openalex.org/W4387211248","https://openalex.org/W4387647991","https://openalex.org/W6733549453"],"related_works":["https://openalex.org/W1602805286","https://openalex.org/W4225917631","https://openalex.org/W2088686453","https://openalex.org/W4200635075","https://openalex.org/W4400475616","https://openalex.org/W4375867731","https://openalex.org/W2149738946","https://openalex.org/W2326681941","https://openalex.org/W4361251389","https://openalex.org/W10455127"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"is":[3,37],"a":[4],"high-grade":[5],"glioma":[6],"with":[7,188],"poor":[8],"overall":[9],"survival":[10],"and":[11,28,44,55,69,120,124,134,149,163],"high":[12],"local":[13],"recurrence":[14],"rates.":[15],"Standard":[16],"treatment":[17],"includes":[18],"surgical":[19],"removal":[20],"of":[21,139],"the":[22,50,82,98],"tumor":[23,53,75,94,100,194],"followed":[24],"by":[25],"radiotherapy":[26],"(RT)":[27],"adjuvant":[29],"chemotherapy.":[30],"In":[31],"RT":[32,103],"planning,":[33],"general":[34],"target":[35],"volume":[36],"manually":[38],"defined":[39],"using":[40,105,130],"contrast-enhanced":[41],"T1-weighted":[42],"(T1-ce)":[43],"T2-FLAIR":[45],"MR":[46,107],"images":[47,179],"to":[48,72,80,90],"locate":[49],"residual":[51],"enhancing":[52,99],"region":[54],"extend":[56],"contours":[57],"on":[58,177,181],"visible":[59],"perifocal":[60],"edema,":[61],"respectively.":[62],"However,":[63],"planning":[64,104],"process":[65],"requires":[66],"strong":[67],"knowledge":[68],"long":[70],"times":[71],"clearly":[73],"define":[74],"contours.":[76],"This":[77],"study":[78],"aims":[79],"find":[81],"best":[83,152,183],"candidate":[84],"between":[85],"several":[86],"open-source":[87],"segmentation":[88,95,175],"networks":[89],"build":[91],"an":[92,135],"automatic":[93],"tool":[96],"for":[97],"delineation":[101],"in":[102,159],"T1-ce":[106],"sequences.":[108],"For":[109],"that":[110],"purpose,":[111],"four":[112],"deep":[113,196],"learning":[114],"models":[115],"including":[116],"nnU-Net,":[117],"TransUNet,":[118],"SwinUNETR":[119],"MedNeXt,":[121],"were":[122],"trained":[123],"tested":[125],"under":[126],"different":[127],"hyperparameter's":[128],"conditions":[129],"BraTS":[131],"public":[132],"dataset":[133],"additional":[136],"private":[137],"cohort":[138],"<tex":[140],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[141,167],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{4":[142],"3}$</tex>":[143],"patients":[144],"as":[145],"external":[146,164],"test.":[147],"nuU-Net":[148],"MedNeXt":[150],"showed":[151],"performances":[153],"reaching":[154],"same":[155],"Dice":[156],"Score":[157],"(DSC)":[158],"both":[160],"validation":[161],"(0.89)":[162],"test":[165],"(<tex":[166],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{0.":[168],"8":[169],"1}$</tex>)":[170],"sets.":[171],"A":[172],"peritumoral":[173],"edema":[174],"model":[176],"T2FLAIR":[178],"built":[180],"nnU-Net's":[182],"configuration":[184],"was":[185],"also":[186],"implemented":[187],"success.":[189],"Index":[190],"Terms-glioblastoma":[191],"multiforme,":[192],"radiotherapy,":[193],"segmentation,":[195],"learning,":[197],"U-Net.":[198]},"counts_by_year":[],"updated_date":"2026-04-17T18:11:37.981687","created_date":"2025-10-10T00:00:00"}