{"id":"https://openalex.org/W4412030543","doi":"https://doi.org/10.1109/cbms65348.2025.00057","title":"Prioritization of Potential Drugs Through Pathway-Based Drug Repurposing and Network Proximity Analysis","display_name":"Prioritization of Potential Drugs Through Pathway-Based Drug Repurposing and Network Proximity Analysis","publication_year":2025,"publication_date":"2025-06-18","ids":{"openalex":"https://openalex.org/W4412030543","doi":"https://doi.org/10.1109/cbms65348.2025.00057"},"language":"en","primary_location":{"id":"doi:10.1109/cbms65348.2025.00057","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms65348.2025.00057","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001918492","display_name":"Bel\u00e9n Otero-Carrasco","orcid":"https://orcid.org/0000-0001-7315-2257"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bel\u00e9n Otero-Carrasco","raw_affiliation_strings":["Universidad Politécnica de Madrid,Centro de Tecnología Biomédica,ETS Ingenieros Informáticos,Madrid,Spain"],"affiliations":[{"raw_affiliation_string":"Universidad Politécnica de Madrid,Centro de Tecnología Biomédica,ETS Ingenieros Informáticos,Madrid,Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039485265","display_name":"Lucia Prieto Santamar\u00eda","orcid":"https://orcid.org/0000-0003-1545-3515"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luc\u00eda Prieto-Santamar\u00eda","raw_affiliation_strings":["Universidad Politécnica de Madrid,Centro de Tecnología Biomédica,ETS Ingenieros Informáticos,Madrid,Spain"],"affiliations":[{"raw_affiliation_string":"Universidad Politécnica de Madrid,Centro de Tecnología Biomédica,ETS Ingenieros Informáticos,Madrid,Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013323586","display_name":"Alejandro Rodr\u00edguez\u2010Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-8801-4762"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alejandro Rodr\u00edguez-Gonz\u00e1lez","raw_affiliation_strings":["Universidad Politécnica de Madrid,Centro de Tecnología Biomédica,ETS Ingenieros Informáticos,Madrid,Spain"],"affiliations":[{"raw_affiliation_string":"Universidad Politécnica de Madrid,Centro de Tecnología Biomédica,ETS Ingenieros Informáticos,Madrid,Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001918492"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20011455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"246","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.799055814743042},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.7648023962974548},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6298533082008362},{"id":"https://openalex.org/keywords/prioritization","display_name":"Prioritization","score":0.6157773733139038},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.571391761302948},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.29234904050827026},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21419230103492737},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15152254700660706},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.07071277499198914}],"concepts":[{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.799055814743042},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.7648023962974548},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6298533082008362},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.6157773733139038},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.571391761302948},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29234904050827026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21419230103492737},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15152254700660706},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.07071277499198914},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cbms65348.2025.00057","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms65348.2025.00057","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6143636310","display_name":null,"funder_award_id":"PID2021-122659OBI00","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2056782561","https://openalex.org/W2062533676","https://openalex.org/W2062941476","https://openalex.org/W2079245674","https://openalex.org/W2100714130","https://openalex.org/W2118346323","https://openalex.org/W2121604817","https://openalex.org/W2130410032","https://openalex.org/W2147241078","https://openalex.org/W2263739890","https://openalex.org/W2568498246","https://openalex.org/W2612467560","https://openalex.org/W2624021832","https://openalex.org/W2790231974","https://openalex.org/W2809645723","https://openalex.org/W2826750344","https://openalex.org/W2896002881","https://openalex.org/W2922229918","https://openalex.org/W2982975240","https://openalex.org/W3098834408","https://openalex.org/W3166527078","https://openalex.org/W4390726926","https://openalex.org/W4395667095","https://openalex.org/W4401687697"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W3186872001"],"abstract_inverted_index":{"Drug":[0],"repurposing":[1,29,187],"is":[2,47,101],"an":[3],"effective":[4,68],"strategy":[5],"to":[6,40,66,141,180],"identify":[7],"novel":[8],"therapeutic":[9],"options":[10],"by":[11],"leveraging":[12],"existing":[13,182],"drugs":[14,64,115,157],"with":[15,58],"known":[16,65],"mechanisms":[17],"of":[18,155,176],"action":[19],"and":[20,37,52,92,98,147],"safety":[21],"profiles.":[22],"This":[23,150],"work":[24],"introduces":[25],"a":[26,108],"pathway-based":[27],"drug":[28],"approach":[30],"that":[31,48],"combines":[32],"protein-protein":[33],"interaction":[34],"(PPI)":[35],"networks":[36],"transcriptomic":[38],"data":[39],"prioritize":[41],"candidate":[42,156],"drugs.":[43],"The":[44],"underlying":[45],"assumption":[46],"if":[49],"disease":[50,53,70,77,90,117,145,165],"1":[51,91,146],"2":[54,71,118],"are":[55,85,96,119,135,171],"both":[56],"associated":[57,94],"the":[59,93,104,123,138,142,148,153,177,185],"same":[60],"biological":[61,162],"pathway,":[62],"then":[63,120],"be":[67,73],"for":[69,76,116,137],"may":[72],"potential":[74,161],"treatments":[75],"1.":[78,166],"To":[79],"explore":[80],"these":[81],"relationships,":[82],"disease\u2013pathway\u2013drug":[83],"triplets":[84],"constructed.":[86],"Genes":[87],"shared":[88],"between":[89,144],"pathway":[95],"identified,":[97],"their":[99,129,160],"proximity":[100,143],"calculated":[102],"within":[103],"PPI":[105],"network":[106],"using":[107,122],"Z-score":[109],"based":[110,158],"on":[111,159,164],"random":[112],"permutations.":[113],"Candidate":[114],"analyzed":[121],"Connectivity":[124],"Map":[125],"data,":[126],"assessing":[127],"whether":[128],"up-":[130],"or":[131],"down-regulated":[132],"gene":[133],"signatures":[134],"enriched":[136],"genes":[139],"contributing":[140],"pathway.":[149],"integration":[151],"enables":[152],"ranking":[154],"impact":[163],"Finally,":[167],"top-ranked":[168],"drug\u2013disease":[169],"associations":[170],"evaluated":[172],"through":[173],"manual":[174],"curation":[175],"scientific":[178],"literature":[179],"assess":[181],"evidence":[183],"supporting":[184],"proposed":[186],"hypothesis.":[188]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}