{"id":"https://openalex.org/W2124895518","doi":"https://doi.org/10.1109/cbms.2009.5255249","title":"Differentiation between brain metastases and glioblastoma multiforme based on MRI, MRS and MRSI","display_name":"Differentiation between brain metastases and glioblastoma multiforme based on MRI, MRS and MRSI","publication_year":2009,"publication_date":"2009-08-01","ids":{"openalex":"https://openalex.org/W2124895518","doi":"https://doi.org/10.1109/cbms.2009.5255249","mag":"2124895518"},"language":"en","primary_location":{"id":"doi:10.1109/cbms.2009.5255249","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2009.5255249","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 22nd IEEE International Symposium on Computer-Based Medical Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111467437","display_name":"Jan Luts","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Jan Luts","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, Leuven, Belgium","Katholieke Universiteit Leuven, Department of Electrical Engineering (ESAT), Research Division SCD, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke Universiteit Leuven, Department of Electrical Engineering (ESAT), Research Division SCD, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078854904","display_name":"Johan A. K. Suykens","orcid":"https://orcid.org/0000-0002-8846-6352"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan A.K. Suykens","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, Leuven, Belgium","Katholieke Universiteit Leuven, Department of Electrical Engineering (ESAT), Research Division SCD, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke Universiteit Leuven, Department of Electrical Engineering (ESAT), Research Division SCD, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049055621","display_name":"Sabine Van Huffel","orcid":"https://orcid.org/0000-0001-5939-0996"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sabine Van Huffel","raw_affiliation_strings":["Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, Leuven, Belgium","Katholieke Universiteit Leuven, Department of Electrical Engineering (ESAT), Research Division SCD, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke Universiteit Leuven, Department of Electrical Engineering (ESAT), Research Division SCD, Kasteelpark Arenberg 10, B-3001 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002510034","display_name":"Teresa Laudadio","orcid":"https://orcid.org/0000-0002-2046-0456"},"institutions":[{"id":"https://openalex.org/I4210106125","display_name":"Istituto per le Applicazioni del Calcolo Mauro Picone","ror":"https://ror.org/00ygy3d85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106125","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Teresa Laudadio","raw_affiliation_strings":["Istituto Applicazioni Calcolo, CNR, Bari, Italy","Istituto Applicazioni Calcolo, CNR, sez. Bari, via G. Amendola 122/D, I-70126 Bari, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Applicazioni Calcolo, CNR, Bari, Italy","institution_ids":["https://openalex.org/I4210106125"]},{"raw_affiliation_string":"Istituto Applicazioni Calcolo, CNR, sez. Bari, via G. Amendola 122/D, I-70126 Bari, Italy","institution_ids":["https://openalex.org/I4210106125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103272191","display_name":"Sofie Van Cauter","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sofie Van Cauter","raw_affiliation_strings":["University Hospitals,Radiology Section, Katholieke Universiteit Leuven, Leuven, Belgium","Katholieke Universiteit Leuven, University Hospitals, Radiology Section, Herestraat 49, B-3000 Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"University Hospitals,Radiology Section, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke Universiteit Leuven, University Hospitals, Radiology Section, Herestraat 49, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004293803","display_name":"Uwe Himmelreich","orcid":"https://orcid.org/0000-0002-2060-8895"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Uwe Himmelreich","raw_affiliation_strings":["University Hospitals,Radiology Section, Katholieke Universiteit Leuven, Leuven, Belgium","Katholieke Universiteit Leuven, University Hospitals, Radiology Section, Herestraat 49, B-3000 Leuven, Belgium"],"affiliations":[{"raw_affiliation_string":"University Hospitals,Radiology Section, Katholieke Universiteit Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Katholieke Universiteit Leuven, University Hospitals, Radiology Section, Herestraat 49, B-3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052149595","display_name":"Enrique Moll\u00e1","orcid":"https://orcid.org/0000-0003-2118-1130"},"institutions":[{"id":"https://openalex.org/I4210094134","display_name":"Hospital de La Ribera","ror":"https://ror.org/00qnmxq60","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094134"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enrique Molla","raw_affiliation_strings":["Radiology Service, Hospital de La Ribera, Valencia, Spain","Hospital de La Ribera, Radiology Service, Carretero Alzira-Corbera, Km 1, Alzira 46600 Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Radiology Service, Hospital de La Ribera, Valencia, Spain","institution_ids":["https://openalex.org/I4210094134"]},{"raw_affiliation_string":"Hospital de La Ribera, Radiology Service, Carretero Alzira-Corbera, Km 1, Alzira 46600 Valencia, Spain","institution_ids":["https://openalex.org/I4210094134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109222349","display_name":"Jos\u00e9 Piquer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210094134","display_name":"Hospital de La Ribera","ror":"https://ror.org/00qnmxq60","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094134"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Piquer","raw_affiliation_strings":["Radiology Service, Hospital de La Ribera, Valencia, Spain","Hospital de La Ribera, Neurosurgery Service, Carretero Alzira-Corbera, Km 1, Alzira 46600 Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Radiology Service, Hospital de La Ribera, Valencia, Spain","institution_ids":["https://openalex.org/I4210094134"]},{"raw_affiliation_string":"Hospital de La Ribera, Neurosurgery Service, Carretero Alzira-Corbera, Km 1, Alzira 46600 Valencia, Spain","institution_ids":["https://openalex.org/I4210094134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010659902","display_name":"M. Carmen Mart\u00ednez\u2010Bisbal","orcid":"https://orcid.org/0000-0002-8526-4413"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. Carmen Martinez-Bisbal","raw_affiliation_strings":["Department of Physical Chemistry CIBER-BBN, ISC-III, University of Valencia, Valencia, Spain","University of Valencia, Department of Physical Chemistry, CIBER-BBN, ISC-III, Valencia, Spain, C/Dr Moliner, 50, Burjassot, 46100 Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry CIBER-BBN, ISC-III, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I2801357902"]},{"raw_affiliation_string":"University of Valencia, Department of Physical Chemistry, CIBER-BBN, ISC-III, Valencia, Spain, C/Dr Moliner, 50, Burjassot, 46100 Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001808454","display_name":"Bernardo Celda","orcid":null},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bernardo Celda","raw_affiliation_strings":["Department of Physical Chemistry CIBER-BBN, ISC-III, University of Valencia, Valencia, Spain","University of Valencia, Department of Physical Chemistry, CIBER-BBN, ISC-III, Valencia, Spain, C/Dr Moliner, 50, Burjassot, 46100 Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry CIBER-BBN, ISC-III, University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I2801357902"]},{"raw_affiliation_string":"University of Valencia, Department of Physical Chemistry, CIBER-BBN, ISC-III, Valencia, Spain, C/Dr Moliner, 50, Burjassot, 46100 Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5111467437"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":null,"apc_paid":null,"fwci":1.086,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80337587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.7566941380500793},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.7253810167312622},{"id":"https://openalex.org/keywords/magnetic-resonance-spectroscopic-imaging","display_name":"Magnetic resonance spectroscopic imaging","score":0.6421642899513245},{"id":"https://openalex.org/keywords/in-vivo-magnetic-resonance-spectroscopy","display_name":"In vivo magnetic resonance spectroscopy","score":0.5687735080718994},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.49594101309776306},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.47421693801879883},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4578200578689575},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.4517171382904053},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"Differential diagnosis","score":0.43282341957092285},{"id":"https://openalex.org/keywords/brain-tumor","display_name":"Brain tumor","score":0.4290160536766052},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4096914529800415},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.25639793276786804},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.11003053188323975},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1051417887210846}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7566941380500793},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7253810167312622},{"id":"https://openalex.org/C96781048","wikidata":"https://www.wikidata.org/wiki/Q6731601","display_name":"Magnetic resonance spectroscopic imaging","level":3,"score":0.6421642899513245},{"id":"https://openalex.org/C103191249","wikidata":"https://www.wikidata.org/wiki/Q624073","display_name":"In vivo magnetic resonance spectroscopy","level":3,"score":0.5687735080718994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49594101309776306},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.47421693801879883},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4578200578689575},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4517171382904053},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.43282341957092285},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4290160536766052},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4096914529800415},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25639793276786804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.11003053188323975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1051417887210846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/cbms.2009.5255249","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cbms.2009.5255249","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 22nd IEEE International Symposium on Computer-Based Medical Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/16"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1496317909","https://openalex.org/W1500895378","https://openalex.org/W1963985312","https://openalex.org/W2017135228","https://openalex.org/W2038112377","https://openalex.org/W2053911432","https://openalex.org/W2072342821","https://openalex.org/W2082929034","https://openalex.org/W2091011326","https://openalex.org/W2096616261","https://openalex.org/W2126768332","https://openalex.org/W2133059825","https://openalex.org/W2133811548","https://openalex.org/W2151879381","https://openalex.org/W2171477255","https://openalex.org/W2330815040","https://openalex.org/W6674403760"],"related_works":["https://openalex.org/W1961357634","https://openalex.org/W2806385170","https://openalex.org/W2063322641","https://openalex.org/W3091791297","https://openalex.org/W2783071479","https://openalex.org/W2150218084","https://openalex.org/W2001278629","https://openalex.org/W2761865063","https://openalex.org/W2523785598","https://openalex.org/W2015010652"],"abstract_inverted_index":{"Brain":[0],"metastases":[1],"and":[2,9,15,39,48,63,79,93,116,138,149],"glioblastoma":[3,91,147],"multiforme":[4,92,148],"are":[5,68,82,87,127,154,161],"the":[6,41,71,97,107,168],"most":[7],"aggressive":[8],"common":[10],"brain":[11,150],"tumours":[12],"in":[13,54,167,182],"adults":[14],"they":[16],"require":[17],"a":[18,142,175],"different":[19],"clinical":[20,28],"management.":[21],"Anatomical":[22],"magnetic":[23,44,49,72],"resonance":[24,45,50,73],"imaging":[25,52],"(MRI)":[26],"or":[27],"history,":[29],"cannot":[30],"always":[31],"clearly":[32],"distinguish":[33,90],"between":[34,146],"them.":[35],"This":[36],"study":[37],"describes":[38],"verifies":[40],"use":[42],"of":[43,61,76,134],"spectroscopy":[46],"(MRS)":[47],"spectroscopic":[51,165],"(MRSI)":[53],"combination":[55,133],"with":[56],"MRI":[57,117,139],"for":[58,129],"differential":[59],"diagnosis":[60],"glioblastomas":[62],"metastases.":[64],"Feature":[65],"selection":[66],"methods":[67,86],"applied":[69],"to":[70,89,112],"(MR)":[74],"spectra":[75],"121":[77],"patients":[78,121],"relevant":[80],"features":[81],"detected.":[83],"Different":[84],"classification":[85],"used":[88,128],"metastasis":[94],"based":[95,156],"on":[96,157],"single-voxel":[98],"MR":[99,136,170],"spectra,":[100],"but":[101],"no":[102],"reliable":[103],"differentiation":[104,130,145],"is":[105],"obtained:":[106],"accuracy":[108],"varies":[109],"from":[110,119],"50":[111],"78%.":[113],"Next,":[114],"MRSI":[115],"data":[118,137,140],"10":[120],"(5":[122],"glioblastomas,":[123],"5":[124],"solitary":[125],"metastases)":[126],"purposes.":[131],"The":[132,152,172],"multivoxel":[135],"suggests":[141],"more":[143],"clear":[144],"metastasis.":[151],"results":[153],"visualized":[155],"nosologic":[158],"images,":[159],"which":[160],"generated":[162],"by":[163],"including":[164],"information":[166],"segmented":[169],"image.":[171],"methodology":[173],"offers":[174],"new":[176],"way":[177],"that":[178],"may":[179],"support":[180],"clinicians":[181],"decision":[183],"making.":[184]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}