{"id":"https://openalex.org/W2032488286","doi":"https://doi.org/10.1109/bmei.2012.6512991","title":"Detect adverse drug reactions for the drug Pravastatin","display_name":"Detect adverse drug reactions for the drug Pravastatin","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2032488286","doi":"https://doi.org/10.1109/bmei.2012.6512991","mag":"2032488286"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2012.6512991","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512991","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11343/241259","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100773842","display_name":"Yihui Liu","orcid":"https://orcid.org/0000-0002-6358-8687"},"institutions":[{"id":"https://openalex.org/I152269853","display_name":"Qilu University of Technology","ror":"https://ror.org/04hyzq608","country_code":"CN","type":"education","lineage":["https://openalex.org/I152269853"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yihui Liu","raw_affiliation_strings":["Qilu University of Technology, Jinan, Shandong, CN","Inst. of Intell. Inf. Process., Shandong Polytech. Univ., Jinan, China"],"affiliations":[{"raw_affiliation_string":"Qilu University of Technology, Jinan, Shandong, CN","institution_ids":["https://openalex.org/I152269853"]},{"raw_affiliation_string":"Inst. of Intell. Inf. Process., Shandong Polytech. Univ., Jinan, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002768704","display_name":"Uwe Aickelin","orcid":"https://orcid.org/0000-0002-2679-2275"},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Uwe Aickelin","raw_affiliation_strings":["Department of Computer Science, University of Nottingham, UK","Department of Computer Science, University of Nottingham, Nottingham UK"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"Department of Computer Science, University of Nottingham, Nottingham UK","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100773842"],"corresponding_institution_ids":["https://openalex.org/I152269853"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.07841069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"74","issue":null,"first_page":"1188","last_page":"1192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.8009270429611206},{"id":"https://openalex.org/keywords/pravastatin","display_name":"Pravastatin","score":0.7424331903457642},{"id":"https://openalex.org/keywords/drug-reaction","display_name":"Drug reaction","score":0.6892153024673462},{"id":"https://openalex.org/keywords/adverse-drug-reaction","display_name":"Adverse drug reaction","score":0.6884858012199402},{"id":"https://openalex.org/keywords/medical-prescription","display_name":"Medical prescription","score":0.5674617290496826},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.5295729637145996},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5026917457580566},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4342019259929657},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4138590693473816},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.34358471632003784},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33289045095443726},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19964838027954102}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.8009270429611206},{"id":"https://openalex.org/C2779519902","wikidata":"https://www.wikidata.org/wiki/Q1240093","display_name":"Pravastatin","level":3,"score":0.7424331903457642},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.6892153024673462},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.6884858012199402},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.5674617290496826},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5295729637145996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5026917457580566},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4342019259929657},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4138590693473816},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34358471632003784},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33289045095443726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19964838027954102},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bmei.2012.6512991","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512991","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/241259","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/241259","pdf_url":"http://hdl.handle.net/11343/241259","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Conference on BioMedical Engineering and Informatics (BMEI)","raw_type":"Conference Paper"}],"best_oa_location":{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/241259","is_oa":true,"landing_page_url":"http://hdl.handle.net/11343/241259","pdf_url":"http://hdl.handle.net/11343/241259","source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Conference on BioMedical Engineering and Informatics (BMEI)","raw_type":"Conference Paper"},"sustainable_development_goals":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2032488286.pdf","grobid_xml":"https://content.openalex.org/works/W2032488286.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W40475248","https://openalex.org/W196541616","https://openalex.org/W1967696247","https://openalex.org/W1970813386","https://openalex.org/W1974317785","https://openalex.org/W1976707339","https://openalex.org/W1981809734","https://openalex.org/W2011301735","https://openalex.org/W2011868777","https://openalex.org/W2015487160","https://openalex.org/W2017008233","https://openalex.org/W2017086415","https://openalex.org/W2024957042","https://openalex.org/W2027629403","https://openalex.org/W2031707540","https://openalex.org/W2039400965","https://openalex.org/W2062032395","https://openalex.org/W2090596950","https://openalex.org/W2091962951","https://openalex.org/W2103776471","https://openalex.org/W2109332572","https://openalex.org/W2110791769","https://openalex.org/W2112028291","https://openalex.org/W2144080401","https://openalex.org/W2151723881","https://openalex.org/W2159666011","https://openalex.org/W2588106347","https://openalex.org/W4252967908","https://openalex.org/W6601675977"],"related_works":["https://openalex.org/W2376885761","https://openalex.org/W2995438986","https://openalex.org/W2398395680","https://openalex.org/W2365386954","https://openalex.org/W2377282230","https://openalex.org/W2348194333","https://openalex.org/W2352744048","https://openalex.org/W2370505849","https://openalex.org/W2347501567","https://openalex.org/W3030394802"],"abstract_inverted_index":{"Adverse":[0],"drug":[1,36,95,102],"reaction":[2],"(ADR)":[3],"is":[4,28,46,115],"widely":[5],"concerned":[6],"for":[7,100],"public":[8],"health":[9],"issue.":[10],"ADRs":[11,81,107],"are":[12,62,90,103,108],"one":[13],"of":[14],"most":[15],"common":[16],"causes":[17],"to":[18,32,41,48,66,78],"withdraw":[19],"some":[20],"drugs":[21],"from":[22,57,64],"market.":[23],"Prescription":[24],"event":[25],"monitoring":[26],"(PEM)":[27],"an":[29,75],"important":[30],"approach":[31,77],"detect":[33,79],"the":[34,51,80,94,101],"adverse":[35],"reactions.":[37],"The":[38,88,105],"main":[39],"problem":[40],"deal":[42],"with":[43],"this":[44,71],"method":[45],"how":[47],"automatically":[49],"extract":[50],"medical":[52,59],"events":[53],"or":[54],"side":[55,98],"effects":[56,99],"high-throughput":[58],"data,":[60],"which":[61],"collected":[63],"day":[65,67],"clinical":[68],"practice.":[69],"In":[70],"study":[72],"we":[73],"propose":[74],"original":[76],"using":[82],"feature":[83,86],"matrix":[84],"and":[85],"selection.":[87],"experiments":[89],"carried":[91],"out":[92],"on":[93,110],"Pravastatin.":[96],"Major":[97],"detected.":[104],"detected":[106],"based":[109],"computerized":[111],"method,":[112],"further":[113],"investigation":[114],"needed.":[116]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}