{"id":"https://openalex.org/W1983257336","doi":"https://doi.org/10.1109/bmei.2012.6512980","title":"Analysis of synonymous codon usage in the Cas1 gene of Riemerella anatipestifer","display_name":"Analysis of synonymous codon usage in the Cas1 gene of Riemerella anatipestifer","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W1983257336","doi":"https://doi.org/10.1109/bmei.2012.6512980","mag":"1983257336"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2012.6512980","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512980","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115602255","display_name":"Yang He","orcid":"https://orcid.org/0000-0002-8530-9132"},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang He","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Sichuan, Agricultural University, Wenjiang, Chengdu city, China","Inst. of Preventive Veterinary Med., Sichuan Agric. Univ., Chengdu, China"],"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Sichuan, Agricultural University, Wenjiang, Chengdu city, China","institution_ids":["https://openalex.org/I37574244"]},{"raw_affiliation_string":"Inst. of Preventive Veterinary Med., Sichuan Agric. Univ., Chengdu, China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045418032","display_name":"Anchun Cheng","orcid":"https://orcid.org/0000-0001-6093-353X"},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anchun Cheng","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu city, China","Inst. of Preventive Veterinary Med., Sichuan Agric. Univ., Chengdu, China"],"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu city, China","institution_ids":["https://openalex.org/I37574244"]},{"raw_affiliation_string":"Inst. of Preventive Veterinary Med., Sichuan Agric. Univ., Chengdu, China","institution_ids":["https://openalex.org/I37574244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102002022","display_name":"Mingshu Wang","orcid":"https://orcid.org/0000-0001-9652-392X"},"institutions":[{"id":"https://openalex.org/I37574244","display_name":"Sichuan Agricultural University","ror":"https://ror.org/0388c3403","country_code":"CN","type":"education","lineage":["https://openalex.org/I37574244"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingshu Wang","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu city, China","Inst. of Preventive Veterinary Med., Sichuan Agric. Univ., Chengdu, China"],"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu city, China","institution_ids":["https://openalex.org/I37574244"]},{"raw_affiliation_string":"Inst. of Preventive Veterinary Med., Sichuan Agric. Univ., Chengdu, China","institution_ids":["https://openalex.org/I37574244"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5115602255"],"corresponding_institution_ids":["https://openalex.org/I37574244"],"apc_list":null,"apc_paid":null,"fwci":0.14016494,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49251241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1138","last_page":"1146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/codon-usage-bias","display_name":"Codon usage bias","score":0.8875008821487427},{"id":"https://openalex.org/keywords/synonymous-substitution","display_name":"Synonymous substitution","score":0.725527286529541},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6974233984947205},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6434658169746399},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5865362286567688},{"id":"https://openalex.org/keywords/start-codon","display_name":"Start codon","score":0.5832459926605225},{"id":"https://openalex.org/keywords/gc-content","display_name":"GC-content","score":0.5797814726829529},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.25861239433288574}],"concepts":[{"id":"https://openalex.org/C87253356","wikidata":"https://www.wikidata.org/wiki/Q1106472","display_name":"Codon usage bias","level":4,"score":0.8875008821487427},{"id":"https://openalex.org/C138025448","wikidata":"https://www.wikidata.org/wiki/Q7662597","display_name":"Synonymous substitution","level":5,"score":0.725527286529541},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6974233984947205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6434658169746399},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5865362286567688},{"id":"https://openalex.org/C176990463","wikidata":"https://www.wikidata.org/wiki/Q1854186","display_name":"Start codon","level":4,"score":0.5832459926605225},{"id":"https://openalex.org/C42251679","wikidata":"https://www.wikidata.org/wiki/Q933491","display_name":"GC-content","level":4,"score":0.5797814726829529},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.25861239433288574},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2012.6512980","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512980","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W193446248","https://openalex.org/W1527267184","https://openalex.org/W1603411458","https://openalex.org/W1951333111","https://openalex.org/W1965233192","https://openalex.org/W1966773394","https://openalex.org/W1975431806","https://openalex.org/W1982026770","https://openalex.org/W1992661401","https://openalex.org/W1992819115","https://openalex.org/W1996423252","https://openalex.org/W2004146038","https://openalex.org/W2004674004","https://openalex.org/W2012063247","https://openalex.org/W2018097321","https://openalex.org/W2018590530","https://openalex.org/W2019604065","https://openalex.org/W2023241472","https://openalex.org/W2023778561","https://openalex.org/W2034076823","https://openalex.org/W2038941962","https://openalex.org/W2039707307","https://openalex.org/W2043397125","https://openalex.org/W2043592686","https://openalex.org/W2050546316","https://openalex.org/W2051861840","https://openalex.org/W2052751186","https://openalex.org/W2054752392","https://openalex.org/W2059661284","https://openalex.org/W2061249175","https://openalex.org/W2064636083","https://openalex.org/W2065120930","https://openalex.org/W2066829062","https://openalex.org/W2068691391","https://openalex.org/W2070163065","https://openalex.org/W2072284352","https://openalex.org/W2072499238","https://openalex.org/W2072806310","https://openalex.org/W2074713139","https://openalex.org/W2076793571","https://openalex.org/W2078146553","https://openalex.org/W2080418977","https://openalex.org/W2081229967","https://openalex.org/W2083685031","https://openalex.org/W2085626106","https://openalex.org/W2090758517","https://openalex.org/W2092549911","https://openalex.org/W2095868955","https://openalex.org/W2096524795","https://openalex.org/W2097382368","https://openalex.org/W2098991500","https://openalex.org/W2100002703","https://openalex.org/W2106201948","https://openalex.org/W2110236168","https://openalex.org/W2114556622","https://openalex.org/W2114945486","https://openalex.org/W2122343942","https://openalex.org/W2123035829","https://openalex.org/W2124549692","https://openalex.org/W2125121305","https://openalex.org/W2127064445","https://openalex.org/W2128774203","https://openalex.org/W2132836838","https://openalex.org/W2133238953","https://openalex.org/W2133609795","https://openalex.org/W2135884205","https://openalex.org/W2143221412","https://openalex.org/W2151171638","https://openalex.org/W2151314777","https://openalex.org/W2153810796","https://openalex.org/W2157613837","https://openalex.org/W2157848631","https://openalex.org/W2159365979","https://openalex.org/W2163464288","https://openalex.org/W2164618276","https://openalex.org/W2350954794","https://openalex.org/W6640675529","https://openalex.org/W6684041852","https://openalex.org/W6705547105"],"related_works":["https://openalex.org/W2028165934","https://openalex.org/W2102511336","https://openalex.org/W2391050383","https://openalex.org/W2092093943","https://openalex.org/W2132060660","https://openalex.org/W2153784832","https://openalex.org/W2059628904","https://openalex.org/W2113191934","https://openalex.org/W1983257336","https://openalex.org/W2992558252"],"abstract_inverted_index":{"Object:":[0],"The":[1,87,124,144,211],"study":[2,24,311],"herein":[3,159],"was":[4,73,137,160,196,246,259],"aimed":[5],"to":[6,140,175,185,198,248,307],"provide":[7],"a":[8,22,200,260,289],"comprehensive":[9],"analysis":[10,273],"of":[11,25,47,56,78,84,105,118,128,146,155,203,213,217,223,242,250,267,280,292,298,312],"synonymous":[12,49],"codon":[13,27,50,64,69,106,125,204,215,231,239],"usage":[14,28,51,107,205,232,240],"in":[15,93,131,189,206,278],"Riemerella":[16],"anatipestifer":[17],"(RA)":[18],"Cas1":[19,91,129,167,208,219,244,269,300],"gene":[20,142,168,220,245],"and":[21,32,67,81,95,113,116,133,181,227,237,296],"comparative":[23],"the":[26,38,45,53,62,68,76,101,152,182,214,238,286,293,309,313],"bias":[29,126,183],"between":[30],"RA":[31,94,132,166,190,207,218,243,268,299],"other":[33],"11":[34,97],"reference":[35,98,135],"strains":[36,99,136],"within":[37],"Flavobacteriaceae":[39],"family.":[40],"Methods:":[41],"Using":[42],"bioinformatics":[43,284],"method,":[44,285],"values":[46],"relative":[48],"(RSCU),":[52],"effective":[54],"number":[55],"codons":[57,174],"(ENc),":[58],"G+C":[59],"content":[60,188],"at":[61],"3rd":[63],"position":[65],"(GC3s),":[66],"adaptation":[70],"index":[71],"(CAI)":[72],"computed":[74],"with":[75,108,221],"help":[77],"CHIPS,":[79],"CUSP,":[80],"CAI":[82],"programs":[83],"EMBOSS.":[85],"Result:":[86],"results":[88],"suggested":[89],"that":[90,151,230,249,257],"genes":[92,130,157],"its":[96,134],"applied":[100],"relatively":[102],"similar":[103,109,247],"pattern":[104,127,241],"sequence":[110],"length,":[111],"CAI,":[112],"ENc":[114,147],"values,":[115],"all":[117],"them":[119],"were":[120],"lowly":[121],"expressed":[122],"genes.":[123,281],"closely":[138],"related":[139],"their":[141],"function.":[143],"plots":[145],"versus":[148],"GC3s":[149],"indicated":[150],"genetic":[153],"heterogeneity":[154],"these":[156],"observed":[158],"constrained":[161],"by":[162],"GC":[163,193],"composition.":[164],"Besides,":[165],"preferred":[169],"A":[170],"or/and":[171,177],"T":[172],"ending":[173,179],"G":[176],"C":[178],"codons,":[180],"corresponded":[184],"high":[186],"A+T":[187],"cas1":[191],"gene.":[192,209,270,314],"compositional":[194],"constraint":[195],"found":[197],"be":[199,255],"major":[201],"determinant":[202],"Additionally,":[210],"comparison":[212],"preference":[216],"those":[222],"E.":[224],"coli,":[225],"yeast,":[226],"human,":[228],"revealed":[229],"varied":[233],"among":[234],"different":[235],"organisms":[236],"yeast.":[251],"Accordingly,":[252],"it":[253],"can":[254],"speculated":[256],"yeast":[258],"well":[261,303],"suited":[262],"host":[263],"for":[264],"heterologous":[265],"expression":[266],"Conclusion:":[271],"Bioinformatics":[272],"plays":[274],"an":[275],"important":[276],"role":[277],"research":[279],"And":[282],"using":[283],"paper":[287],"provides":[288],"foundational":[290],"understanding":[291],"molecular":[294],"evolution":[295],"function":[297],"gene,":[301],"as":[302,304],"contributes":[305],"significantly":[306],"guiding":[308],"further":[310]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}