{"id":"https://openalex.org/W2032798819","doi":"https://doi.org/10.1109/bmei.2012.6512949","title":"1196-Chamber compatible LOC device with bubble valves for signaling molecular profiling in blood","display_name":"1196-Chamber compatible LOC device with bubble valves for signaling molecular profiling in blood","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2032798819","doi":"https://doi.org/10.1109/bmei.2012.6512949","mag":"2032798819"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2012.6512949","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512949","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062767191","display_name":"Xinyan Zhao","orcid":"https://orcid.org/0000-0002-4252-5812"},"institutions":[{"id":"https://openalex.org/I51213786","display_name":"Vestfold University College","ror":"https://ror.org/00zcy2665","country_code":"NO","type":"education","lineage":["https://openalex.org/I2801380234","https://openalex.org/I51213786"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Xinyan Zhao","raw_affiliation_strings":["Norwegian Center of Expertise on Micro- and Nano Technology, HiVE Vestfold University College, Tonsberg, Norway","Norwegian Center of Expertise on Micro- & Nano Technol., HiVE Vestfold Univ. Coll., Tonsberg, Norway"],"affiliations":[{"raw_affiliation_string":"Norwegian Center of Expertise on Micro- and Nano Technology, HiVE Vestfold University College, Tonsberg, Norway","institution_ids":["https://openalex.org/I51213786"]},{"raw_affiliation_string":"Norwegian Center of Expertise on Micro- & Nano Technol., HiVE Vestfold Univ. Coll., Tonsberg, Norway","institution_ids":["https://openalex.org/I51213786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100734419","display_name":"Tao Dong","orcid":"https://orcid.org/0000-0002-6229-1013"},"institutions":[{"id":"https://openalex.org/I51213786","display_name":"Vestfold University College","ror":"https://ror.org/00zcy2665","country_code":"NO","type":"education","lineage":["https://openalex.org/I2801380234","https://openalex.org/I51213786"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Tao Dong","raw_affiliation_strings":["Norwegian Center of Expertise on Micro- and Nano Technology, HiVE Vestfold University College, Tonsberg, Norway","Norwegian Center of Expertise on Micro- & Nano Technol., HiVE Vestfold Univ. Coll., Tonsberg, Norway"],"affiliations":[{"raw_affiliation_string":"Norwegian Center of Expertise on Micro- and Nano Technology, HiVE Vestfold University College, Tonsberg, Norway","institution_ids":["https://openalex.org/I51213786"]},{"raw_affiliation_string":"Norwegian Center of Expertise on Micro- & Nano Technol., HiVE Vestfold Univ. Coll., Tonsberg, Norway","institution_ids":["https://openalex.org/I51213786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062767191"],"corresponding_institution_ids":["https://openalex.org/I51213786"],"apc_list":null,"apc_paid":null,"fwci":0.1313,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50898263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"684","last_page":"687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasba","display_name":"NASBA","score":0.5256857872009277},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.5143190622329712},{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.5038627982139587},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.47487136721611023},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.4614289104938507},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.46037325263023376},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.39931997656822205},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3776114881038666},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36931487917900085},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3418278992176056},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20001095533370972},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18822064995765686},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.14508876204490662},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1393936276435852},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.1038549542427063},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.09790986776351929},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09125420451164246}],"concepts":[{"id":"https://openalex.org/C2779695955","wikidata":"https://www.wikidata.org/wiki/Q3869370","display_name":"NASBA","level":4,"score":0.5256857872009277},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.5143190622329712},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.5038627982139587},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.47487136721611023},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4614289104938507},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.46037325263023376},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.39931997656822205},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3776114881038666},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36931487917900085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3418278992176056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20001095533370972},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18822064995765686},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.14508876204490662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1393936276435852},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1038549542427063},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09790986776351929},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09125420451164246},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2012.6512949","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512949","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"},{"id":"https://openalex.org/F4320324852","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760"},{"id":"https://openalex.org/F4320325434","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785"},{"id":"https://openalex.org/F4320326972","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57"},{"id":"https://openalex.org/F4320329781","display_name":"Hubei University","ror":"https://ror.org/03a60m280"},{"id":"https://openalex.org/F4320335642","display_name":"Institute of Hydrobiology","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1976124481","https://openalex.org/W1981010476","https://openalex.org/W1990956712","https://openalex.org/W1991646828","https://openalex.org/W2012170433","https://openalex.org/W2020296675","https://openalex.org/W2030542989","https://openalex.org/W2043263760","https://openalex.org/W2056281984","https://openalex.org/W2056423446","https://openalex.org/W2079351138","https://openalex.org/W2088493543","https://openalex.org/W2142896472","https://openalex.org/W4240941162"],"related_works":["https://openalex.org/W2967136651","https://openalex.org/W2033684641","https://openalex.org/W2913646003","https://openalex.org/W2081632393","https://openalex.org/W2147509954","https://openalex.org/W1970773045","https://openalex.org/W4389944751","https://openalex.org/W2409063720","https://openalex.org/W2566736735","https://openalex.org/W3092671456"],"abstract_inverted_index":{"The":[0,91,111,142],"present":[1],"medical":[2],"technology":[3],"cannot":[4],"radically":[5],"cure":[6],"many":[7],"chronic":[8],"diseases,":[9],"which":[10,81,100],"often":[11],"involved":[12],"the":[13,37,52,65,87,132,147,150],"interaction":[14],"between":[15],"different":[16,40],"organs":[17],"or":[18],"systems":[19,53],"in":[20,36,78,108],"human":[21,55],"body.":[22,56],"Since":[23],"signaling":[24,42,154],"molecules,":[25],"such":[26],"as":[27,129,136],"hormones,":[28],"neurotransmitters,":[29],"cytokines":[30],"etc.,":[31],"play":[32],"a":[33,58,97,120,157],"key":[34],"role":[35],"communication":[38],"of":[39,51,89,115],"organs,":[41],"molecular":[43],"profiling":[44],"(SMP)":[45],"could":[46,82],"provide":[47],"an":[48],"intelligible":[49],"overview":[50],"inside":[54],"Here,":[57],"1196-chamber":[59],"Lab-on-a-chip":[60],"(LOC)":[61],"device":[62],"based":[63],"on":[64,96],"quantitative":[66],"aptamer-NASBA":[67],"(nucleic":[68],"acid":[69],"sequence-based":[70],"amplification)":[71],"assay":[72],"was":[73,113],"developed":[74],"to":[75,137,152],"monitor":[76],"SMP":[77],"serum":[79],"samples,":[80],"help":[83],"doctors":[84],"fully":[85],"understand":[86],"body":[88],"patients.":[90],"disposable":[92],"chip":[93,112,133],"is":[94,101],"modeled":[95],"1536-well":[98],"microplate,":[99],"completely":[102],"compatible":[103],"with":[104,119],"common":[105],"microplate":[106],"readers":[107],"biological":[109],"laboratories.":[110],"made":[114],"PDMS":[116],"and":[117],"silicon":[118],"deposited":[121],"gold":[122],"layer.":[123],"Notably,":[124],"air":[125],"bubbles":[126],"were":[127],"introduced":[128],"valves":[130],"into":[131],"deliberately":[134],"so":[135],"isolate":[138],"every":[139],"reaction":[140],"chamber.":[141],"preliminary":[143],"test":[144],"indicated":[145],"that":[146],"LOC":[148],"has":[149],"potential":[151],"quantify":[153],"molecules":[155],"at":[156],"femtomolar":[158],"level.":[159]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
