{"id":"https://openalex.org/W1991171389","doi":"https://doi.org/10.1109/bmei.2012.6512893","title":"Explore coronary artery disease related microRNA clusters by combing single nucleotide polymorphisms with microRNA microarray","display_name":"Explore coronary artery disease related microRNA clusters by combing single nucleotide polymorphisms with microRNA microarray","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W1991171389","doi":"https://doi.org/10.1109/bmei.2012.6512893","mag":"1991171389"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2012.6512893","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512893","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089487302","display_name":"Lin Hua","orcid":"https://orcid.org/0000-0001-6309-3572"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Hua","raw_affiliation_strings":["Department of Bioinformatics, Biomedical Engineering Institute, Capital Medical University, Beijing, China, 100069","Dept. of Bioinf., Capital Med. Univ., Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biomedical Engineering Institute, Capital Medical University, Beijing, China, 100069","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Dept. of Bioinf., Capital Med. Univ., Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101978690","display_name":"Zheng Yang","orcid":"https://orcid.org/0000-0002-7081-6588"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Yang","raw_affiliation_strings":["Department of Bioinformatics, Biomedical Engineering Institute, Capital Medical University, Beijing, China, 100069","Dept. of Bioinf., Capital Med. Univ., Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biomedical Engineering Institute, Capital Medical University, Beijing, China, 100069","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Dept. of Bioinf., Capital Med. Univ., Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100410327","display_name":"Hong Liu","orcid":"https://orcid.org/0000-0002-7534-1710"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Department of Bioinformatics, Biomedical Engineering Institute, Capital Medical University, Beijing, China, 100069","Dept. of Bioinf., Capital Med. Univ., Beijing, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Biomedical Engineering Institute, Capital Medical University, Beijing, China, 100069","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Dept. of Bioinf., Capital Med. Univ., Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5089487302"],"corresponding_institution_ids":["https://openalex.org/I183519381"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.05651451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1193","last_page":"1197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.8094898462295532},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7538632154464722},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.6403303742408752},{"id":"https://openalex.org/keywords/genotyping","display_name":"Genotyping","score":0.6389791965484619},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6339101195335388},{"id":"https://openalex.org/keywords/snp-genotyping","display_name":"SNP genotyping","score":0.586129367351532},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.5734493732452393},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5414543151855469},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4667532742023468},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43350949883461},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.42580389976501465},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4235076308250427},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4214437007904053},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3334144055843353},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.2620524764060974},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23591282963752747},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16086912155151367},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.06092721223831177}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.8094898462295532},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7538632154464722},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6403303742408752},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6389791965484619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6339101195335388},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.586129367351532},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5734493732452393},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5414543151855469},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4667532742023468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43350949883461},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.42580389976501465},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4235076308250427},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4214437007904053},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3334144055843353},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2620524764060974},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23591282963752747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16086912155151367},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06092721223831177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2012.6512893","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2012.6512893","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 5th International Conference on BioMedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1972404712","https://openalex.org/W1980740976","https://openalex.org/W1998938150","https://openalex.org/W2009890490","https://openalex.org/W2017598790","https://openalex.org/W2059145105","https://openalex.org/W2067245109","https://openalex.org/W2110275824","https://openalex.org/W2115440941","https://openalex.org/W2127981150","https://openalex.org/W2129894911","https://openalex.org/W2134783591","https://openalex.org/W2140482300","https://openalex.org/W2159165136","https://openalex.org/W2160905065"],"related_works":["https://openalex.org/W2414446413","https://openalex.org/W2331649876","https://openalex.org/W1504890006","https://openalex.org/W2783076127","https://openalex.org/W2026621123","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416"],"abstract_inverted_index":{"In":[0],"recent":[1],"years,":[2],"microRNAs":[3,127],"(miRNAs)":[4],"play":[5],"critical":[6],"roles":[7],"in":[8,24,78,143,150],"many":[9],"important":[10,86],"biological":[11],"processes,":[12],"and":[13,109,138],"are":[14],"therefore":[15,71],"studied":[16],"as":[17,140,142],"key":[18],"regulators":[19],"of":[20,34,36,38,65],"gene":[21],"expression":[22],"involved":[23],"complex":[25,91],"diseases.":[26,92],"On":[27],"the":[28,31,145,151],"other":[29],"hand,":[30],"simultaneous":[32],"genotyping":[33],"hundreds":[35],"thousands":[37],"single":[39],"nucleotide":[40],"polymorphisms":[41],"(SNP)":[42],"have":[43],"provided":[44],"an":[45],"excellent":[46],"chance":[47],"for":[48,102],"genome-wide":[49,100],"association":[50],"studies":[51],"(GWAS).":[52],"However,":[53],"currently":[54],"identified":[55,125],"genetic":[56],"variants":[57],"collectively":[58],"can":[59,133],"explain":[60],"only":[61],"a":[62,99],"small":[63],"proportion":[64],"disease":[66],"phenotypic":[67],"variance.":[68],"It":[69],"is":[70],"suggested":[72],"that":[73],"functional":[74,111,116],"SNPs":[75,77,118],"or":[76,81,128],"microRNA":[79,129],"genes":[80],"target":[82],"sites":[83],"might":[84],"be":[85],"signals":[87],"associated":[88],"with":[89,120],"human":[90],"To":[93],"explore":[94],"disease-related":[95],"microRNAs,":[96,123],"we":[97,124],"performed":[98],"scan":[101],"WTCCC-CAD":[103],"(coronary":[104],"artery":[105],"disease)":[106],"SNP":[107],"data,":[108],"extracted":[110],"risk":[112,117],"SNPs.":[113],"By":[114],"combining":[115],"(genes)":[119],"differentially":[121],"expressed":[122],"CAD-related":[126],"clusters.":[130],"Our":[131],"method":[132],"help":[134],"understanding":[135],"miRNA":[136],"function":[137],"disease,":[139],"well":[141],"exploring":[144],"novel":[146],"mechanism":[147],"connecting":[148],"miRNAs":[149],"function.":[152]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}