{"id":"https://openalex.org/W2168995446","doi":"https://doi.org/10.1109/bmei.2009.5305727","title":"Signal Pathway in Sinusitis, Polyps and Normal Nasal Mucosa through Bioinformatics Analysis on Differentially Expressed-Proteins","display_name":"Signal Pathway in Sinusitis, Polyps and Normal Nasal Mucosa through Bioinformatics Analysis on Differentially Expressed-Proteins","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2168995446","doi":"https://doi.org/10.1109/bmei.2009.5305727","mag":"2168995446"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5305727","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305727","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076854982","display_name":"Xuedong Chen","orcid":"https://orcid.org/0000-0001-9459-8418"},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuedong Chen","raw_affiliation_strings":["Third Xiangya Hospital, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Third Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I4210156904","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037209779","display_name":"Faqing Tang","orcid":"https://orcid.org/0000-0003-0279-2956"},"institutions":[{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]},{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Faqing Tang","raw_affiliation_strings":["Third Xiangya Hospital, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Third Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I4210156904","https://openalex.org/I139660479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100769310","display_name":"Hong Sun","orcid":"https://orcid.org/0000-0002-6225-2241"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Sun","raw_affiliation_strings":["Third Xiangya Hospital, Central South University, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Third Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I4210156904","https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076854982"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.22770094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9426000118255615,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9426000118255615,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9107000231742859,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasal-polyps","display_name":"Nasal polyps","score":0.8434154987335205},{"id":"https://openalex.org/keywords/sinusitis","display_name":"Sinusitis","score":0.689841091632843},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.6177441477775574},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.5919229984283447},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5769884586334229},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5622934103012085},{"id":"https://openalex.org/keywords/mucous-membrane-of-nose","display_name":"Mucous membrane of nose","score":0.5512932538986206},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.44455960392951965},{"id":"https://openalex.org/keywords/chronic-sinusitis","display_name":"Chronic sinusitis","score":0.44236594438552856},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"Signal peptide","score":0.4332132637500763},{"id":"https://openalex.org/keywords/gel-electrophoresis","display_name":"Gel electrophoresis","score":0.4258934259414673},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.3838012218475342},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2849345803260803},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2634633779525757},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.2348748743534088},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23466721177101135},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.222753643989563},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.1742561161518097},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11256217956542969},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10416486859321594}],"concepts":[{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.8434154987335205},{"id":"https://openalex.org/C2777768476","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Sinusitis","level":2,"score":0.689841091632843},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6177441477775574},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5919229984283447},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5769884586334229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5622934103012085},{"id":"https://openalex.org/C59377437","wikidata":"https://www.wikidata.org/wiki/Q515471","display_name":"Mucous membrane of nose","level":2,"score":0.5512932538986206},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44455960392951965},{"id":"https://openalex.org/C2994554258","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Chronic sinusitis","level":3,"score":0.44236594438552856},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.4332132637500763},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.4258934259414673},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3838012218475342},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2849345803260803},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2634633779525757},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2348748743534088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23466721177101135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.222753643989563},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.1742561161518097},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11256217956542969},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10416486859321594}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5305727","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305727","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1992974026","https://openalex.org/W2000770184","https://openalex.org/W2072749750","https://openalex.org/W2076841345","https://openalex.org/W2101489028","https://openalex.org/W2141056237"],"related_works":["https://openalex.org/W3028782225","https://openalex.org/W2366374131","https://openalex.org/W2465691133","https://openalex.org/W2400328107","https://openalex.org/W2978492413","https://openalex.org/W3032722983","https://openalex.org/W2033081851","https://openalex.org/W2353490438","https://openalex.org/W2371062252","https://openalex.org/W1986377866"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"target":[3],"moleculars":[4],"and":[5,23,28,47,60,62,67,87,101,108,121,139,170,185,206],"signal":[6,174,211],"pathways":[7,71,175,212],"involved":[8,75,171],"in":[9,65,76,103,172,195],"chronic":[10,19,104,222],"sinusitis,":[11,20,105,223],"nasal":[12,21,25,106,110,148,159,224],"polyps.":[13,225],"Methods:":[14],"Proteins":[15],"were":[16,29,53,77,114,130,154],"extracted":[17],"from":[18],"polyps":[22,107],"normal":[24,109,147],"mucosa":[26,111,149,160],"tissue,":[27,150],"separated":[30,100],"by":[31,79],"the":[32,127,178],"immobilized":[33],"pH4-7":[34],"gradient":[35],"two-dimensional":[36],"sodium":[37],"dodecyl":[38],"sulfate":[39],"polyacrylamide":[40],"gel":[41,113],"electrophoresis.":[42],"The":[43,97],"peptide":[44],"mass":[45],"fingerprint":[46],"sequence":[48],"tag":[49],"of":[50,90,165,192,218,221],"differentially":[51,155],"expressed-proteins":[52],"gotten":[54],"with":[55,202],"PDQuest":[56],"analysis":[57],"software,":[58],"MALDITOF-MS":[59],"ESI-Q-TOF-MS,":[61],"Mascot":[63],"searching":[64,83],"NCBInr":[66],"SWISS-PROT":[68],"databases.":[69],"Signal":[70],"which":[72,176],"these":[73],"proteins":[74,194],"analyzed":[78],"linking":[80],"KEGG":[81,84],"web,":[82],"PATHWAY":[85],"databases,":[86],"P":[88],"value":[89],"ultra":[91],"geometric":[92],"distribution":[93],"was":[94],"counted.":[95],"Results:":[96],"protein":[98,152],"spots":[99,153,164],"visualized":[102],"tissue":[112,161],"1112":[115],"plusmn":[116,119,123,132,136,141],"10,":[117],"1020":[118],"40":[120],"1008":[122],"25":[124],"respectively.":[125,144],"And":[126],"match":[128],"rates":[129],"(95":[131],"1)":[133],"%,":[134],"(93":[135],"2)":[137],"%":[138,143],"(90":[140],"3)":[142],"Compared":[145],"to":[146],"thirty":[151],"expressed":[156],"among":[157],"those":[158],"gels.":[162],"13":[163],"them":[166],"could":[167,197],"be":[168,198,214],"labeled":[169],"18":[173],"including":[177],"fatty":[179],"acid":[180],"metabolism":[181],"pathway,":[182],"PPAR":[183],"pathway":[184],"cell":[186],"communication":[187],"pathway.":[188],"A":[189],"large":[190],"number":[191],"mark":[193,217],"disease":[196],"more":[199],"rapidly":[200],"taken":[201],"uniting":[203],"proteomics":[204],"technology":[205],"bioinformatics":[207],"technology.":[208],"Conclusion:":[209],"These":[210],"may":[213],"an":[215],"important":[216],"molecule":[219],"typing":[220]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}