{"id":"https://openalex.org/W2132565462","doi":"https://doi.org/10.1109/bmei.2009.5305639","title":"Particulate Joint Replacement Materials Induce Apoptosis of Rabbit Synoviocytes Cell Line HIG-82 through c-Jun N-Terminal Kinase (JNK) Pathway","display_name":"Particulate Joint Replacement Materials Induce Apoptosis of Rabbit Synoviocytes Cell Line HIG-82 through c-Jun N-Terminal Kinase (JNK) Pathway","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2132565462","doi":"https://doi.org/10.1109/bmei.2009.5305639","mag":"2132565462"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5305639","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011661970","display_name":"Feng-Min Chu","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Feng-Min Chu","raw_affiliation_strings":["Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan","Dept. of Mater. Sci. & Eng., Nat. Taiwan Univ., Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Dept. of Mater. Sci. & Eng., Nat. Taiwan Univ., Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112007702","display_name":"Shuang\u2013Shii Lian","orcid":null},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shuang-Shii Lian","raw_affiliation_strings":["Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan","Dept. of Mater. Sci. & Eng., Nat. Taiwan Univ., Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Dept. of Mater. Sci. & Eng., Nat. Taiwan Univ., Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110260777","display_name":"Yen\u2010Jen Sung","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Jen Sung","raw_affiliation_strings":["Institute of Anatomy & Cell Biology, National Yang-Ming University, Taipei, Taiwan","Inst. of Anatomy & Cell Biol., Nat. Yang-Ming Univ., Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"Institute of Anatomy & Cell Biology, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Inst. of Anatomy & Cell Biol., Nat. Yang-Ming Univ., Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011661970"],"corresponding_institution_ids":["https://openalex.org/I16733864"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.21199451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"63 b","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.953000009059906,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.7549142837524414},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6298906803131104},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.5093892216682434},{"id":"https://openalex.org/keywords/viability-assay","display_name":"Viability assay","score":0.4971485435962677},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4811743199825287},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.4482446610927582},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4217199683189392},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.39687758684158325},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20082536339759827},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14595448970794678}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7549142837524414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6298906803131104},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5093892216682434},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4971485435962677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4811743199825287},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4482446610927582},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4217199683189392},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39687758684158325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20082536339759827},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14595448970794678},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5305639","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305639","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1490172408","https://openalex.org/W1792973268","https://openalex.org/W1977503911","https://openalex.org/W1988336043","https://openalex.org/W2005128372","https://openalex.org/W2008378818","https://openalex.org/W2042752375","https://openalex.org/W2070044720","https://openalex.org/W2070619151","https://openalex.org/W2083156043","https://openalex.org/W2128872721","https://openalex.org/W2472497433","https://openalex.org/W4236422923"],"related_works":["https://openalex.org/W3148810057","https://openalex.org/W2755853517","https://openalex.org/W2380755462","https://openalex.org/W3152233030","https://openalex.org/W2471519923","https://openalex.org/W3150682115","https://openalex.org/W4385687789","https://openalex.org/W2949991425","https://openalex.org/W1565061379","https://openalex.org/W2059634348"],"abstract_inverted_index":{"Many":[0],"studies":[1],"have":[2,54],"focused":[3],"on":[4,63],"the":[5,29,46,56,130],"biological":[6],"responses":[7,33],"of":[8,58,94,118,132],"macrophages,":[9],"osteoblasts,":[10],"and":[11,38,71,84],"osteoclasts":[12],"cells":[13,44],"after":[14],"knee":[15,47],"joint":[16,30],"replacements.":[17],"However,":[18],"synoviocytes":[19,64],"are":[20],"also":[21],"in":[22,50,90,107,110],"close":[23],"contact":[24],"with":[25],"wear":[26,61],"particles":[27,62,80],"within":[28],"cavity;":[31],"their":[32],"would":[34],"influence":[35],"other":[36],"cells,":[37],"they":[39],"may":[40,124],"serve":[41],"as":[42],"inflammatory":[43],"around":[45],"joint.":[48],"Therefore,":[49],"this":[51],"study":[52,114],"we":[53],"examined":[55],"affects":[57],"1~2":[59],"Vm":[60],"(HIG-82":[65],"cell)":[66],"through":[67],"cell":[68],"viability,":[69],"apoptosis":[70,83,93,109,119],"immunoblotting":[72],"assays.":[73],"The":[74],"results":[75],"indicated":[76],"that":[77],"metal":[78],"cobalt":[79,100],"induced":[81],"significant":[82,106],"activated":[85],"JNK":[86,121],"(c-jun":[87],"N-terminal":[88],"kinase),":[89],"turn":[91],"causing":[92,108],"HIG-82":[95,111],"cells.":[96,112],"In":[97],"contrast":[98],"to":[99],"particles,":[101],"titanium":[102],"dioxide":[103],"was":[104],"not":[105],"This":[113],"proposes":[115],"a":[116],"pathway":[117],"involving":[120],"activation.":[122],"It":[123],"be":[125],"an":[126],"important":[127],"concept":[128],"for":[129],"prevention":[131],"prosthesis":[133],"loosening.":[134]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
