{"id":"https://openalex.org/W2103064589","doi":"https://doi.org/10.1109/bmei.2009.5305424","title":"Effects of Electrical Stimulation on Growth and Metabolism of Cardiomyocytes In Vitro","display_name":"Effects of Electrical Stimulation on Growth and Metabolism of Cardiomyocytes In Vitro","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2103064589","doi":"https://doi.org/10.1109/bmei.2009.5305424","mag":"2103064589"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5305424","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305424","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100363326","display_name":"Yong Guo","orcid":"https://orcid.org/0000-0001-6485-7925"},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Guo","raw_affiliation_strings":["Tianjin Institute of Medical Equipmen, Tianjin city, China","Tianjin Inst. of Med. Equipmen, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Medical Equipmen, Tianjin city, China","institution_ids":[]},{"raw_affiliation_string":"Tianjin Inst. of Med. Equipmen, Tianjin, China","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wei","raw_affiliation_strings":["Tianjin Institute of Medical Equipmen, Tianjin city, China","Tianjin Inst. of Med. Equipmen, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Medical Equipmen, Tianjin city, China","institution_ids":[]},{"raw_affiliation_string":"Tianjin Inst. of Med. Equipmen, Tianjin, China","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089152634","display_name":"Xizheng Zhang","orcid":"https://orcid.org/0000-0003-2261-5973"},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi-zheng Zhang","raw_affiliation_strings":["Tianjin Institute of Medical Equipmen, Tianjin city, China","Tianjin Inst. of Med. Equipmen, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Medical Equipmen, Tianjin city, China","institution_ids":[]},{"raw_affiliation_string":"Tianjin Inst. of Med. Equipmen, Tianjin, China","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019757750","display_name":"Yu-xian Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-xian Yan","raw_affiliation_strings":["Tianjin Institute of Medical Equipmen, Tianjin city, China","Tianjin Inst. of Med. Equipmen, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Medical Equipmen, Tianjin city, China","institution_ids":[]},{"raw_affiliation_string":"Tianjin Inst. of Med. Equipmen, Tianjin, China","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008167844","display_name":"Ruixin Li","orcid":"https://orcid.org/0000-0001-7718-1370"},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui-xin Li","raw_affiliation_strings":["Tianjin Institute of Medical Equipmen, Tianjin city, China","Tianjin Inst. of Med. Equipmen, Tianjin, China"],"affiliations":[{"raw_affiliation_string":"Tianjin Institute of Medical Equipmen, Tianjin city, China","institution_ids":[]},{"raw_affiliation_string":"Tianjin Inst. of Med. Equipmen, Tianjin, China","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007464113","display_name":"Chun\u2010qiu Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I136765683","display_name":"Tianjin University of Technology","ror":"https://ror.org/00zbe0w13","country_code":"CN","type":"education","lineage":["https://openalex.org/I136765683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-qiu Zhang","raw_affiliation_strings":["School of Mechanical Engineering, Tianjin University of technology, China","Sch. of Mech. Eng., TianJin Univ. of Technol., Tianjin, China"],"affiliations":[{"raw_affiliation_string":"School of Mechanical Engineering, Tianjin University of technology, China","institution_ids":["https://openalex.org/I136765683"]},{"raw_affiliation_string":"Sch. of Mech. Eng., TianJin Univ. of Technol., Tianjin, China","institution_ids":["https://openalex.org/I136765683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100363326"],"corresponding_institution_ids":["https://openalex.org/I4210105139"],"apc_list":null,"apc_paid":null,"fwci":0.5903,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.73832338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"20","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propidium-iodide","display_name":"Propidium iodide","score":0.9611433744430542},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.8232622146606445},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"Lactate dehydrogenase","score":0.7227294445037842},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.6019649505615234},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5487422347068787},{"id":"https://openalex.org/keywords/atpase","display_name":"ATPase","score":0.5164484977722168},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.47027474641799927},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4373306334018707},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42533552646636963},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.4115595519542694},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36950525641441345},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.30491048097610474},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22491496801376343},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17513182759284973},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.173524409532547},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.10834121704101562}],"concepts":[{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.9611433744430542},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.8232622146606445},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.7227294445037842},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6019649505615234},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5487422347068787},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5164484977722168},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47027474641799927},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4373306334018707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42533552646636963},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4115595519542694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36950525641441345},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30491048097610474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22491496801376343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17513182759284973},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.173524409532547},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.10834121704101562},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5305424","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305424","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1493738841","https://openalex.org/W1604813364","https://openalex.org/W1865348810","https://openalex.org/W2011548785","https://openalex.org/W2016668488","https://openalex.org/W2042162895","https://openalex.org/W2062221551","https://openalex.org/W2063053096","https://openalex.org/W2085273994","https://openalex.org/W2114943937","https://openalex.org/W2125454893","https://openalex.org/W2163845660","https://openalex.org/W2168072019"],"related_works":["https://openalex.org/W2383463315","https://openalex.org/W2473880663","https://openalex.org/W2110929160","https://openalex.org/W2361625425","https://openalex.org/W2373675175","https://openalex.org/W2351810720","https://openalex.org/W2365320098","https://openalex.org/W2548081959","https://openalex.org/W2594471212","https://openalex.org/W2435174847"],"abstract_inverted_index":{"In":[0,20,135],"vivo,":[1],"cardiomyocytes":[2,16,27,51,73,116,146,157],"are":[3],"stimulated":[4],"by":[5,37],"electricity":[6],"continuously.":[7],"So":[8],"electrical":[9,29,39,78,137,153],"stimulation":[10,30,40,79,138,154],"is":[11],"an":[12],"indispensable":[13],"factor":[14],"for":[15,156],"cultured":[17],"in":[18,42,58,147,159],"vitro.":[19,43],"this":[21],"study,":[22],"the":[23,59,72,77,86,149],"experimental":[24],"group":[25],"neonatal":[26,145],"received":[28],"at":[31,80,106,139],"different":[32,35],"intensities":[33],"and":[34,48,54,68,83,88,130,167],"frequencies":[36],"a":[38],"device":[41],"After":[44],"stimulation,":[45],"The":[46],"morphology":[47,87],"beating":[49],"of":[50,64,71,95,124,152],"were":[52,74,101,128],"observed,":[53],"lactate":[55,90,119],"dehydrogenase":[56,91,120],"released":[57],"culture":[60],"medium,":[61],"positive":[62,93,122],"ratio":[63,94,123],"propidium":[65,96,125],"iodide":[66,97,126],"staining,":[67,98],"ATPase":[69,99,131],"activity":[70,100,132],"measured.":[75],"When":[76],"low":[81,84],"intensity":[82,108,141],"frequency,":[85],"beating,":[89,118],"released,":[92],"all":[102],"almost":[103],"unchangeable.":[104],"However,":[105],"higher":[107,112],"(10":[109],"V/cm)":[110],"or":[111,142],"frequency":[113,143],"(3.5":[114],"Hz),":[115],"stopped":[117],"leaking,":[121],"staining":[127],"increased,":[129],"was":[133,161],"reduced.":[134],"conclusion,":[136],"high":[140],"damnified":[144],"vitro,":[148],"proper":[150],"parameter":[151],"favourable":[155],"metabolism":[158],"vitro":[160],"less":[162],"than":[163],"10":[164],"V/cm":[165],"(intensity)":[166],"3.5":[168],"Hz":[169],"(frequency).":[170]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}