{"id":"https://openalex.org/W2135759251","doi":"https://doi.org/10.1109/bmei.2009.5305055","title":"Prediction of Presynaptic and Postsynaptic Neurotoxins Using Hybrid Approach and Pseudo Amino Acid Composition","display_name":"Prediction of Presynaptic and Postsynaptic Neurotoxins Using Hybrid Approach and Pseudo Amino Acid Composition","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2135759251","doi":"https://doi.org/10.1109/bmei.2009.5305055","mag":"2135759251"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5305055","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305055","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057225835","display_name":"Lei Yang","orcid":"https://orcid.org/0000-0002-1133-9099"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Yang","raw_affiliation_strings":["Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University for the Nationalities, Hohhot, China","Lab. of Theor. Biophys., Inner Mongolia Univ., Hohhot, China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University for the Nationalities, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]},{"raw_affiliation_string":"Lab. of Theor. Biophys., Inner Mongolia Univ., Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054199900","display_name":"Qian\u2010Zhong Li","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianzhong Li","raw_affiliation_strings":["Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University for the Nationalities, Hohhot, China","Lab. of Theor. Biophys., Inner Mongolia Univ., Hohhot, China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University for the Nationalities, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]},{"raw_affiliation_string":"Lab. of Theor. Biophys., Inner Mongolia Univ., Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001300435","display_name":"Yongchun Zuo","orcid":"https://orcid.org/0000-0002-6065-7835"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchun Zuo","raw_affiliation_strings":["Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University for the Nationalities, Hohhot, China","Lab. of Theor. Biophys., Inner Mongolia Univ., Hohhot, China"],"affiliations":[{"raw_affiliation_string":"Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University for the Nationalities, Hohhot, China","institution_ids":["https://openalex.org/I2722730"]},{"raw_affiliation_string":"Lab. of Theor. Biophys., Inner Mongolia Univ., Hohhot, China","institution_ids":["https://openalex.org/I2722730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057225835"],"corresponding_institution_ids":["https://openalex.org/I2722730"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15132412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.844088077545166},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6283493041992188},{"id":"https://openalex.org/keywords/pseudo-amino-acid-composition","display_name":"Pseudo amino acid composition","score":0.5356124639511108},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4931149184703827},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.44832199811935425},{"id":"https://openalex.org/keywords/neurotoxin","display_name":"Neurotoxin","score":0.4403848946094513},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36819738149642944},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3605385422706604},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.329987108707428},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32640165090560913},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.2936599850654602},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21713191270828247}],"concepts":[{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.844088077545166},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6283493041992188},{"id":"https://openalex.org/C2780362125","wikidata":"https://www.wikidata.org/wiki/Q7254464","display_name":"Pseudo amino acid composition","level":4,"score":0.5356124639511108},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4931149184703827},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.44832199811935425},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.4403848946094513},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36819738149642944},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3605385422706604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.329987108707428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32640165090560913},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2936599850654602},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21713191270828247},{"id":"https://openalex.org/C2779138802","wikidata":"https://www.wikidata.org/wiki/Q418602","display_name":"Dipeptide","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5305055","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5305055","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6700000166893005}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W98799986","https://openalex.org/W1533140015","https://openalex.org/W1910173829","https://openalex.org/W1964329838","https://openalex.org/W1973169354","https://openalex.org/W1989932358","https://openalex.org/W1992577925","https://openalex.org/W1996989509","https://openalex.org/W1998354148","https://openalex.org/W2018235493","https://openalex.org/W2035956573","https://openalex.org/W2038773874","https://openalex.org/W2051872583","https://openalex.org/W2060596828","https://openalex.org/W2065100216","https://openalex.org/W2074348748","https://openalex.org/W2083030073","https://openalex.org/W2084835129","https://openalex.org/W2090008197","https://openalex.org/W2094931538","https://openalex.org/W2102354653","https://openalex.org/W2120026469","https://openalex.org/W2122977798","https://openalex.org/W2128801478","https://openalex.org/W2132292391","https://openalex.org/W2145957695","https://openalex.org/W2149730127","https://openalex.org/W2153153865","https://openalex.org/W2160227697","https://openalex.org/W2160979370","https://openalex.org/W2161716000","https://openalex.org/W2162132908","https://openalex.org/W4240680233","https://openalex.org/W4388253463","https://openalex.org/W6857946432"],"related_works":["https://openalex.org/W1993002098","https://openalex.org/W1983439316","https://openalex.org/W2163884975","https://openalex.org/W4236816050","https://openalex.org/W2095142123","https://openalex.org/W2810344763","https://openalex.org/W2802989292","https://openalex.org/W4311141805","https://openalex.org/W2362489261","https://openalex.org/W2135759251"],"abstract_inverted_index":{"Neurotoxins":[0],"can":[1],"be":[2],"divided":[3],"into":[4],"presynaptic":[5,85,106],"neurotoxins":[6,9,18,29,48,88,107,130],"and":[7,25,38,86,108,138],"postsynaptic":[8,87,111],"based":[10,59],"on":[11,60],"their":[12],"mechanism":[13],"of":[14,35,45,63,75,93,136],"action.":[15],"The":[16,91],"two":[17,47],"have":[19,30],"important":[20,52],"application":[21],"in":[22,53,133],"basic":[23],"research":[24],"drug":[26],"design.":[27],"Presynaptic":[28],"been":[31],"used":[32,127],"for":[33,83,105,110],"treatment":[34],"migraine":[36],"headache":[37],"cerebral":[39],"palsy.":[40],"Therefore,":[41],"the":[42,61,100,122,134,140,146,152],"successful":[43],"prediction":[44],"these":[46],"is":[49,89,125],"becoming":[50],"very":[51],"recent":[54],"years.":[55],"In":[56,113],"this":[57],"article,":[58],"concept":[62],"Chou's":[64],"pseudo":[65],"amino":[66],"acid":[67],"compositions,":[68],"a":[69],"novel":[70],"ED-SVM":[71],"algorithm":[72,118,124],"combined":[73],"increment":[74],"diversity":[76],"(ED)":[77],"with":[78,119],"support":[79],"vector":[80],"machine":[81],"(SVM)":[82],"predicting":[84],"proposed.":[90],"results":[92],"five":[94,153],"fold":[95,154],"cross":[96,155],"validation":[97],"show":[98],"that":[99,131],"sentivity":[101],"are":[102,149],"respectively":[103],"98.72%":[104],"79.71%":[109],"neurotoxins.":[112],"order":[114],"to":[115,128],"compare":[116],"ID-SVM":[117,123],"other":[120],"approaches,":[121],"also":[126],"predict":[129],"described":[132],"work":[135],"Saha":[137],"Raghava,":[139],"higher":[141],"predictive":[142],"success":[143],"rates":[144],"than":[145],"previous":[147],"algorithms":[148],"obtained":[150],"by":[151],"validation.":[156]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}