{"id":"https://openalex.org/W2123345300","doi":"https://doi.org/10.1109/bmei.2009.5304861","title":"Reducing without Side Effects? A Novel Strategy for Designing the PPAR Agonists","display_name":"Reducing without Side Effects? A Novel Strategy for Designing the PPAR Agonists","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2123345300","doi":"https://doi.org/10.1109/bmei.2009.5304861","mag":"2123345300"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5304861","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5304861","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050504481","display_name":"Yea-Huey Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yea-Huey Chang","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","China Medical University Taichung"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"China Medical University Taichung","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110311695","display_name":"DA-TIAN BAU","orcid":null},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210094500","display_name":"Terry Fox Research Institute","ror":"https://ror.org/00mtf6c40","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210094500"]}],"countries":["CA","TW"],"is_corresponding":false,"raw_author_name":"Da-Tian Bau","raw_affiliation_strings":["Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","Terry Fox Cancer Research Lab"],"affiliations":[{"raw_affiliation_string":"Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Terry Fox Cancer Research Lab","institution_ids":["https://openalex.org/I4210094500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113996324","display_name":"Ming\u2010Hsui Tsai","orcid":null},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Hsui Tsai","raw_affiliation_strings":["Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","Otolaryngology Head Neck Surgery"],"affiliations":[{"raw_affiliation_string":"Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Otolaryngology Head Neck Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067002588","display_name":"Yuan\u2010Man Hsu","orcid":"https://orcid.org/0000-0002-4575-7475"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yuan-Man Hsu","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","China Medical University Taichung"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"China Medical University Taichung","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021867307","display_name":"Tin\u2010Yun Ho","orcid":"https://orcid.org/0000-0003-2390-1461"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tin-Yun Ho","raw_affiliation_strings":["Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan","China Medical University Taichung"],"affiliations":[{"raw_affiliation_string":"Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"China Medical University Taichung","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100710720","display_name":"Chien\u2010Yu Chen","orcid":"https://orcid.org/0000-0002-6940-6389"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien-Yu Chen","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","China Medical University Taichung"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"China Medical University Taichung","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034415756","display_name":"Hung-Jin Huang","orcid":"https://orcid.org/0000-0003-2448-3919"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hung-Jin Huang","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","China Medical University Taichung"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"China Medical University Taichung","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030324810","display_name":"Fuu\u2010Jen Tsai","orcid":"https://orcid.org/0000-0002-1373-245X"},"institutions":[{"id":"https://openalex.org/I4210126829","display_name":"China Medical University Hospital","ror":"https://ror.org/0368s4g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210126829"]},{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Fuu-Jen Tsai","raw_affiliation_strings":["Department of Bioinformatics, Asia University, Taichung, Taiwan","Department of Medical Genetics, Pediatrics and Medical Research, Hospital and College of Chinese Medicine, China Medical University, Taichung, Taiwan","[Dept. of Bioinf., Asia Univ., Taichung, Taiwan]"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Department of Medical Genetics, Pediatrics and Medical Research, Hospital and College of Chinese Medicine, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210126829","https://openalex.org/I184693016"]},{"raw_affiliation_string":"[Dept. of Bioinf., Asia Univ., Taichung, Taiwan]","institution_ids":["https://openalex.org/I143578492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112822928","display_name":"Chang\u2010Hai Tsai","orcid":null},"institutions":[{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chang-Hai Tsai","raw_affiliation_strings":["Department of Healthcare Administration, Asia University, Taichung, Taiwan","Asia Univ.  (Taiwan)"],"affiliations":[{"raw_affiliation_string":"Department of Healthcare Administration, Asia University, Taichung, Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"Asia Univ.  (Taiwan)","institution_ids":["https://openalex.org/I143578492"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108033766","display_name":"Calvin Yu\u2010Chian Chen","orcid":"https://orcid.org/0000-0003-3306-250X"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I143578492","display_name":"Asia University","ror":"https://ror.org/038a1tp19","country_code":"TW","type":"education","lineage":["https://openalex.org/I143578492"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Calvin Yu-Chian Chen","raw_affiliation_strings":["Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","Asia University Taiwan","China Medical University Taichung"],"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacoinformatics and Nanotechnology, Department of Biological Science and Technology, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Terry Fox Cancer Research Laboratory, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Asia University Taiwan","institution_ids":["https://openalex.org/I143578492"]},{"raw_affiliation_string":"China Medical University Taichung","institution_ids":["https://openalex.org/I184693016"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5050504481"],"corresponding_institution_ids":["https://openalex.org/I184693016"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.1481051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacophore","display_name":"Pharmacophore","score":0.9499057531356812},{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.9129220247268677},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.6504842042922974},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5305018424987793},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptor","display_name":"Peroxisome proliferator-activated receptor","score":0.4319899082183838},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3980615735054016},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3866598606109619},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3051062226295471},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.2898485064506531},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.2198595106601715},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2117004692554474},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10779613256454468},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10103863477706909}],"concepts":[{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.9499057531356812},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.9129220247268677},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6504842042922974},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5305018424987793},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.4319899082183838},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3980615735054016},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3866598606109619},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3051062226295471},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2898485064506531},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2198595106601715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2117004692554474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10779613256454468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10103863477706909},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5304861","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5304861","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.47999998927116394}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324301","display_name":"China Medical University","ror":"https://ror.org/032d4f246"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1976396917","https://openalex.org/W1979213955","https://openalex.org/W2004228538","https://openalex.org/W2008404887","https://openalex.org/W2026610312","https://openalex.org/W2062551263","https://openalex.org/W2088660229"],"related_works":["https://openalex.org/W42225299","https://openalex.org/W2943414817","https://openalex.org/W2197392606","https://openalex.org/W2059558045","https://openalex.org/W2021051369","https://openalex.org/W2314430254","https://openalex.org/W2333220762","https://openalex.org/W2225633491","https://openalex.org/W2002578321","https://openalex.org/W2001552790"],"abstract_inverted_index":{"In":[0],"this":[1],"investigation,":[2],"the":[3,8,20,47,51,74,85,89,95],"CoMFA":[4],"and":[5,79,100],"CoMSIA":[6],"in":[7,23],"three-dimensional":[9],"quantitative":[10],"structure-activity":[11],"relationship":[12],"(3D-QSAR)":[13],"studies":[14,78],"were":[15,31],"implemented":[16],"to":[17,64],"search":[18,65,83],"for":[19,62],"pharmacophore":[21],"features":[22],"each":[24,54],"target":[25],"receptor.":[26],"QSAR":[27],"pharmacophores":[28],"hypothesis":[29],"models":[30],"made":[32,44],"from":[33],"a":[34],"series":[35],"of":[36,46,53,70,73,76],"ligands":[37],"by":[38],"their":[39],"activity":[40],"values.":[41],"Besides,":[42],"we":[43,82],"use":[45],"docking":[48,80],"strategy":[49],"between":[50],"structures":[52],"PPARs":[55],"subtype.":[56],"Eventually,":[57],"selectivity":[58],"factor":[59],"is":[60],"employed":[61],"us":[63],"new":[66],"drugs.":[67],"By":[68],"means":[69],"taking":[71],"advantage":[72],"results":[75],"3D-QSAR":[77],"strategy,":[81],"out":[84],"specific":[86],"drugs":[87],"fitting":[88],"two":[90],"PPAR":[91,97],"subtypes":[92],"but":[93],"repelling":[94],"other":[96],"subtype":[98],"effectively":[99],"selectively.":[101]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}