{"id":"https://openalex.org/W2104139259","doi":"https://doi.org/10.1109/bmei.2009.5301815","title":"Prediction of Human Disease Genes Based on Associations between Phenome and Proteins","display_name":"Prediction of Human Disease Genes Based on Associations between Phenome and Proteins","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2104139259","doi":"https://doi.org/10.1109/bmei.2009.5301815","mag":"2104139259"},"language":"en","primary_location":{"id":"doi:10.1109/bmei.2009.5301815","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5301815","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109302852","display_name":"Guangri Quan","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangri Quan","raw_affiliation_strings":["Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China"],"affiliations":[{"raw_affiliation_string":"Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101699138","display_name":"Yu Du","orcid":"https://orcid.org/0000-0001-8341-5225"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Du","raw_affiliation_strings":["Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China"],"affiliations":[{"raw_affiliation_string":"Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109260617","display_name":"Junheng Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junheng Huang","raw_affiliation_strings":["Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China"],"affiliations":[{"raw_affiliation_string":"Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392447","display_name":"Yadong Wang","orcid":"https://orcid.org/0000-0001-6500-6217"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadong Wang","raw_affiliation_strings":["Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China"],"affiliations":[{"raw_affiliation_string":"Bioinf. Res. Center, Harbin Inst. of Technol., Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109302852"],"corresponding_institution_ids":["https://openalex.org/I204983213"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14325528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"78","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenome","display_name":"Phenome","score":0.9053142070770264},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6457065343856812},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5847318172454834},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5777450203895569},{"id":"https://openalex.org/keywords/human-disease","display_name":"Human disease","score":0.5633704662322998},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5376893281936646},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4904279410839081},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4889463186264038},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4255322813987732},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"Clinical phenotype","score":0.4130627512931824},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3436740040779114},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3375436067581177},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33067065477371216},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2904428541660309},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1452597677707672},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1225678026676178}],"concepts":[{"id":"https://openalex.org/C7952369","wikidata":"https://www.wikidata.org/wiki/Q844116","display_name":"Phenome","level":4,"score":0.9053142070770264},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6457065343856812},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5847318172454834},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5777450203895569},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.5633704662322998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5376893281936646},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4904279410839081},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4889463186264038},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4255322813987732},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.4130627512931824},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3436740040779114},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3375436067581177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33067065477371216},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2904428541660309},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1452597677707672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1225678026676178},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bmei.2009.5301815","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bmei.2009.5301815","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 2nd International Conference on Biomedical Engineering and Informatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1605637875","https://openalex.org/W1989684700","https://openalex.org/W2015631955","https://openalex.org/W2020301095","https://openalex.org/W2034044880","https://openalex.org/W2070412833","https://openalex.org/W2070448217","https://openalex.org/W2089817566","https://openalex.org/W2094608127","https://openalex.org/W2097498614","https://openalex.org/W2098381128","https://openalex.org/W2104261859","https://openalex.org/W2105813018","https://openalex.org/W2105887574","https://openalex.org/W2108181223","https://openalex.org/W2114796514","https://openalex.org/W2119943416","https://openalex.org/W2130787066","https://openalex.org/W2134406094","https://openalex.org/W2142304903","https://openalex.org/W2142968125","https://openalex.org/W2154654747","https://openalex.org/W2159843177","https://openalex.org/W2163456090","https://openalex.org/W4238448376"],"related_works":["https://openalex.org/W3009438210","https://openalex.org/W3037132967","https://openalex.org/W3010444534","https://openalex.org/W3157580922","https://openalex.org/W2947302526","https://openalex.org/W3164771895","https://openalex.org/W2604464132","https://openalex.org/W2161088626","https://openalex.org/W3029893540","https://openalex.org/W2314682585"],"abstract_inverted_index":{"Disease":[0],"genes":[1],"identification":[2],"is":[3,27,44,53],"the":[4,7,30,60,75],"key":[5],"to":[6],"issue":[8],"of":[9,20,62,66,70],"human":[10,21],"genetic":[11,22],"diseases":[12],"cure.":[13],"This":[14,56],"paper":[15],"describes":[16],"a":[17,85],"new":[18,40],"method":[19],"disease":[23],"gene":[24],"prediction,":[25],"which":[26,43],"based":[28,45],"on":[29,46],"relations":[31],"between":[32,64],"clinical":[33],"manifestations":[34],"and":[35,49,68,83],"protein-protein":[36],"interaction":[37],"network.":[38],"A":[39],"prediction":[41],"model":[42,58],"associated":[47],"probability":[48],"Pearson":[50],"correlation":[51],"coefficient":[52],"also":[54],"described.":[55],"mathematical":[57],"reflects":[59],"regularity":[61],"associations":[63],"similarities":[65],"phenotypes":[67],"interactions":[69],"proteins.":[71],"It":[72],"can":[73],"describe":[74],"real":[76],"biological":[77],"systems":[78],"better":[79],"than":[80],"traditional":[81],"models,":[82],"gives":[84],"stronger":[86],"predictive":[87],"ability.":[88]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}