{"id":"https://openalex.org/W2018707980","doi":"https://doi.org/10.1109/bibmw.2011.6112555","title":"Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy","display_name":"Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2018707980","doi":"https://doi.org/10.1109/bibmw.2011.6112555","mag":"2018707980"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2011.6112555","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112555","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050914900","display_name":"Chifeng Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chifeng Ma","raw_affiliation_strings":["Department of ECE, University of Texas-San Antonio, San Antonio, TX, USA","Department of ECE, University of Texas at San Antonio, San Antonio, Texas, USA"],"affiliations":[{"raw_affiliation_string":"Department of ECE, University of Texas-San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I45438204"]},{"raw_affiliation_string":"Department of ECE, University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062358477","display_name":"Huang-I Harry","orcid":null},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huang-I Harry","raw_affiliation_strings":["Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"],"affiliations":[{"raw_affiliation_string":"Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068887242","display_name":"Yufei Huang","orcid":"https://orcid.org/0000-0001-6268-5357"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yufei Huang","raw_affiliation_strings":["Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","Department of ECE, University of Texas at San Antonio, San Antonio, Texas, USA"],"affiliations":[{"raw_affiliation_string":"Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of ECE, University of Texas at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100689057","display_name":"Yidong Chen","orcid":"https://orcid.org/0000-0001-6806-2185"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yidong Chen","raw_affiliation_strings":["Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"],"affiliations":[{"raw_affiliation_string":"Greehey Childrens Cancer Research Institute, University of Texas Health Science Center, San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5050914900"],"corresponding_institution_ids":["https://openalex.org/I45438204"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09788147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1045","last_page":"1047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6872209906578064},{"id":"https://openalex.org/keywords/action","display_name":"Action (physics)","score":0.5478538870811462},{"id":"https://openalex.org/keywords/mode-of-action","display_name":"Mode of action","score":0.5473846793174744},{"id":"https://openalex.org/keywords/mode","display_name":"Mode (computer interface)","score":0.5381056070327759},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5143736600875854},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4829230010509491},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3496702313423157},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08412748575210571},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.08271121978759766}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6872209906578064},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.5478538870811462},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.5473846793174744},{"id":"https://openalex.org/C48677424","wikidata":"https://www.wikidata.org/wiki/Q6888088","display_name":"Mode (computer interface)","level":2,"score":0.5381056070327759},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5143736600875854},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4829230010509491},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3496702313423157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08412748575210571},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08271121978759766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2011.6112555","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112555","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2005750374","https://openalex.org/W2007601283","https://openalex.org/W2018786027","https://openalex.org/W2028236537","https://openalex.org/W2029980980","https://openalex.org/W2033525264","https://openalex.org/W2108187125","https://openalex.org/W2113530405","https://openalex.org/W2125080028","https://openalex.org/W2132807006","https://openalex.org/W2144917073","https://openalex.org/W2170845559","https://openalex.org/W2189497403"],"related_works":["https://openalex.org/W4206379684","https://openalex.org/W2366105490","https://openalex.org/W2580680567","https://openalex.org/W4285170202","https://openalex.org/W114270996","https://openalex.org/W4249200654","https://openalex.org/W2396656278","https://openalex.org/W3011011760","https://openalex.org/W2407625558","https://openalex.org/W3121582993"],"abstract_inverted_index":{"This":[0],"work":[1],"aims":[2],"at":[3],"addressing":[4],"the":[5,9,40,48,56,78],"problems":[6],"existed":[7],"in":[8],"original":[10,79],"cMap":[11,49,65,80],"algorithm":[12],"and":[13,31,47,73,76],"proposed":[14],"a":[15],"new":[16],"drug":[17,44,58,67],"Mode-of":[18],"Action":[19],"Network":[20],"construction":[21,30],"scheme":[22],"including":[23],"data":[24],"pre-processing,":[25],"signature":[26],"gene":[27],"extraction,":[28],"network":[29,46,52,69],"query":[32],"prediction.":[33],"Multiple":[34],"analyses":[35],"were":[36],"conducted":[37],"to":[38],"investigate":[39],"structure":[41],"of":[42],"constructed":[43],"mode-of-action":[45],"based":[50,66],"Mode-of-Action":[51,68],"is":[53,70],"tested":[54],"on":[55],"independent":[57],"treatment":[59],"datasets.":[60],"All":[61],"result":[62],"shows":[63],"our":[64],"both":[71],"statistically":[72],"biologically":[74],"significant":[75],"out-perform":[77],"project.":[81]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}