{"id":"https://openalex.org/W2059109618","doi":"https://doi.org/10.1109/bibmw.2011.6112461","title":"A randomized, controlled study of efficacy and safety on mild to moderate insomnia intervened by Chinese medicine in the integrated program","display_name":"A randomized, controlled study of efficacy and safety on mild to moderate insomnia intervened by Chinese medicine in the integrated program","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2059109618","doi":"https://doi.org/10.1109/bibmw.2011.6112461","mag":"2059109618"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2011.6112461","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112461","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048936273","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-5311-9190"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Li","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103127978","display_name":"Biyun Xu","orcid":"https://orcid.org/0000-0002-5610-2677"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biyun Xu","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053674695","display_name":"Shuhui Chen","orcid":"https://orcid.org/0000-0001-7413-8174"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhui Chen","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100346770","display_name":"Peng Liu","orcid":"https://orcid.org/0000-0001-8823-2399"},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Liu","raw_affiliation_strings":["New Drug R & D Center, Guangzhou University of traditional Chinese Medicine, Guangzhou, China","New Drug R & D Center of Guangzhou University of traditional Chinese Medicine. Guangzhou, China#TAB#"],"affiliations":[{"raw_affiliation_string":"New Drug R & D Center, Guangzhou University of traditional Chinese Medicine, Guangzhou, China","institution_ids":["https://openalex.org/I37987034"]},{"raw_affiliation_string":"New Drug R & D Center of Guangzhou University of traditional Chinese Medicine. Guangzhou, China#TAB#","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082690569","display_name":"Aihua Ou","orcid":"https://orcid.org/0000-0001-6123-7931"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aihua Ou","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061020342","display_name":"Yan Xu","orcid":"https://orcid.org/0000-0002-4523-4439"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Xu","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066125658","display_name":"Zehuai Wen","orcid":"https://orcid.org/0000-0002-1797-2047"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zehuai Wen","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081264391","display_name":"OU Bi-yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Biyang Ou","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058467010","display_name":"XU Rui-yu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiyu Xu","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063621064","display_name":"Zhaozhang Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I4210102738","display_name":"Guangzhou Liwan District Traditional Chinese Medicine Hospital","ror":"https://ror.org/016bped08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaozhang Wei","raw_affiliation_strings":["Liwan hospital of Guangzhou Medical collegname of organization, Guangzhou, China","Liwan hospital of Guangzhou Medical collegname of organization Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Liwan hospital of Guangzhou Medical collegname of organization, Guangzhou, China","institution_ids":["https://openalex.org/I4210102738"]},{"raw_affiliation_string":"Liwan hospital of Guangzhou Medical collegname of organization Guangzhou, China","institution_ids":["https://openalex.org/I4210102738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032559235","display_name":"Liang Zeng","orcid":"https://orcid.org/0000-0002-4517-7470"},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Zeng","raw_affiliation_strings":["Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China"],"affiliations":[{"raw_affiliation_string":"Psychology and sleep Department, Guangdong Provincial Hospital of TCM, Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Psychology and sleep Dept. Guangdong Provincial Hospital of TCM. Guangzhou, China","institution_ids":["https://openalex.org/I4210105984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5048936273"],"corresponding_institution_ids":["https://openalex.org/I4210105984"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.15149027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":null,"first_page":"732","last_page":"739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13143","display_name":"Child Therapy and Development","score":0.9196000099182129,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insomnia","display_name":"Insomnia","score":0.8488360643386841},{"id":"https://openalex.org/keywords/sleep-hygiene","display_name":"Sleep hygiene","score":0.7633766531944275},{"id":"https://openalex.org/keywords/acupuncture","display_name":"Acupuncture","score":0.6926921010017395},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.6812933087348938},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6521342992782593},{"id":"https://openalex.org/keywords/placebo","display_name":"Placebo","score":0.5467263460159302},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.5405240654945374},{"id":"https://openalex.org/keywords/sleep-disorder","display_name":"Sleep disorder","score":0.47075536847114563},{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.47017496824264526},{"id":"https://openalex.org/keywords/balance","display_name":"Balance (ability)","score":0.4234272837638855},{"id":"https://openalex.org/keywords/sleep-quality","display_name":"Sleep quality","score":0.33462685346603394},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.2398030161857605},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"Alternative medicine","score":0.21137896180152893},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2056664526462555}],"concepts":[{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.8488360643386841},{"id":"https://openalex.org/C2780975770","wikidata":"https://www.wikidata.org/wiki/Q1364783","display_name":"Sleep hygiene","level":4,"score":0.7633766531944275},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.6926921010017395},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.6812933087348938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6521342992782593},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5467263460159302},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5405240654945374},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.47075536847114563},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.47017496824264526},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4234272837638855},{"id":"https://openalex.org/C2983189541","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep quality","level":3,"score":0.33462685346603394},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2398030161857605},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.21137896180152893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2056664526462555},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2011.6112461","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112461","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.49000000953674316,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328715","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2028226075","https://openalex.org/W2043906606","https://openalex.org/W2143299204","https://openalex.org/W2144411582","https://openalex.org/W2262049082","https://openalex.org/W2351833769","https://openalex.org/W2385793114","https://openalex.org/W2388871484","https://openalex.org/W2389225555","https://openalex.org/W2417424540","https://openalex.org/W6681386212","https://openalex.org/W6692399008","https://openalex.org/W6716970429"],"related_works":["https://openalex.org/W2131587017","https://openalex.org/W2150034468","https://openalex.org/W2129344959","https://openalex.org/W3161898439","https://openalex.org/W2759313768","https://openalex.org/W1980534695","https://openalex.org/W3028730062","https://openalex.org/W3121161304","https://openalex.org/W4281733801","https://openalex.org/W2006084864"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,16,26,45,94,101,110,116,122,159],"effectiveness":[3],"and":[4,71,81,87,97,130,148,151,154],"safety":[5],"in":[6,15,93,100],"mild":[7,33,137],"to":[8,21,34,44,138],"moderate":[9,35,139],"insomnia":[10],"intervened":[11],"by":[12],"Chinese":[13,55],"Medicine":[14],"integrated":[17],"program.":[18],"Methods:":[19],"Patients(18":[20],"56":[22],"years":[23],"old)":[24],"from":[25],"Five":[27],"National":[28],"Center,":[29],"who":[30],"were":[31,37,73,113,125],"with":[32,136,145],"insomnia,":[36,140],"randomly":[38],"divided":[39],"into":[40],"two":[41],"groups":[42],"according":[43],"central,":[46],"experimental":[47,111,123],"group:":[48,59],"sleep":[49,60,89,141],"hygiene":[50,61,142],"instruction":[51,62],"+":[52,63,66],"balance":[53],"acupuncture+":[54],"herbal":[56],"drug;":[57],"control":[58,117],"minor":[64],"acupuncture":[65],"placebo":[67],"capsules.":[68],"PSQI,":[69],"ISI":[70,98],"PSG":[72,119],"assessed":[74],"separately":[75],"after":[76,131],"different":[77,128],"stages":[78],"of":[79,107,109,121],"treatment":[80,108],"follow-up":[82],"evaluation.":[83],"Results:":[84],"(1)":[85],"Subjective":[86],"objective":[88],"quality:":[90],"PSQI":[91],"scores":[92,99],"29th":[95,105],"days":[96,103,106],"15th":[102],"or":[104],"group":[112,124],"lower":[114],"than":[115],"group.":[118],"parameters":[120],"not":[126],"significantly":[127],"before":[129],"treatment.":[132],"Conclusion:":[133],"For":[134],"patients":[135],"education,":[143],"combined":[144],"Balance":[146],"Acupuncture":[147],"Bupleurum":[149],"chinense":[150],"fossil":[152],"fragment":[153],"shellfish":[155],"decoction":[156],"can":[157],"improve":[158],"subjective":[160],"sleep.":[161]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
