{"id":"https://openalex.org/W2063198633","doi":"https://doi.org/10.1109/bibmw.2011.6112421","title":"Evaluation of essential genes in correlation networks using measures of centrality","display_name":"Evaluation of essential genes in correlation networks using measures of centrality","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2063198633","doi":"https://doi.org/10.1109/bibmw.2011.6112421","mag":"2063198633"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2011.6112421","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112421","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005196882","display_name":"Kathryn Dempsey","orcid":null},"institutions":[{"id":"https://openalex.org/I122266389","display_name":"University of Nebraska at Omaha","ror":"https://ror.org/04yrkc140","country_code":"US","type":"education","lineage":["https://openalex.org/I122266389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Dempsey","raw_affiliation_strings":["College of Information Science & Technology, University of Nebraska-Omaha, USA"],"affiliations":[{"raw_affiliation_string":"College of Information Science & Technology, University of Nebraska-Omaha, USA","institution_ids":["https://openalex.org/I122266389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047703641","display_name":"Hesham Ali","orcid":"https://orcid.org/0000-0001-6675-7987"},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"funder","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Ali","raw_affiliation_strings":["Department of Pathology & Microbiology, University of Nebraska Medical Center, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology & Microbiology, University of Nebraska Medical Center, USA","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005196882"],"corresponding_institution_ids":["https://openalex.org/I122266389"],"apc_list":null,"apc_paid":null,"fwci":0.2606,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.57757104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.930769681930542},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.744462251663208},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.7010922431945801},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5812838077545166},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5654398202896118},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.5378113985061646},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5185902118682861},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43968671560287476},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.432422399520874},{"id":"https://openalex.org/keywords/graph-theory","display_name":"Graph theory","score":0.4305155873298645},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4296647012233734},{"id":"https://openalex.org/keywords/network-science","display_name":"Network science","score":0.4276350140571594},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.41224753856658936},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.4032255709171295},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3765295445919037},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24275866150856018},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21015509963035583},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20713874697685242},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17572975158691406},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07784909009933472}],"concepts":[{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.930769681930542},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.744462251663208},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.7010922431945801},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5812838077545166},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5654398202896118},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.5378113985061646},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5185902118682861},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43968671560287476},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.432422399520874},{"id":"https://openalex.org/C88230418","wikidata":"https://www.wikidata.org/wiki/Q131476","display_name":"Graph theory","level":2,"score":0.4305155873298645},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4296647012233734},{"id":"https://openalex.org/C137753397","wikidata":"https://www.wikidata.org/wiki/Q2434424","display_name":"Network science","level":3,"score":0.4276350140571594},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.41224753856658936},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.4032255709171295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3765295445919037},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24275866150856018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21015509963035583},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20713874697685242},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17572975158691406},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07784909009933472},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2011.6112421","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2011.6112421","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1504510381","https://openalex.org/W1978606767","https://openalex.org/W1987824870","https://openalex.org/W1989921625","https://openalex.org/W2031947549","https://openalex.org/W2032492828","https://openalex.org/W2036363967","https://openalex.org/W2037839118","https://openalex.org/W2039296833","https://openalex.org/W2057207151","https://openalex.org/W2057498577","https://openalex.org/W2060705109","https://openalex.org/W2082990265","https://openalex.org/W2106474670","https://openalex.org/W2107084703","https://openalex.org/W2111004700","https://openalex.org/W2122804136","https://openalex.org/W2130410032","https://openalex.org/W2130790725","https://openalex.org/W2134586291","https://openalex.org/W2142720308","https://openalex.org/W2156499012","https://openalex.org/W2163480486","https://openalex.org/W4230450987"],"related_works":["https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W2791736663","https://openalex.org/W2129949791","https://openalex.org/W2806770614","https://openalex.org/W1710460698","https://openalex.org/W249159571","https://openalex.org/W2727283706","https://openalex.org/W2135602072"],"abstract_inverted_index":{"Correlation":[0],"networks":[1,103],"are":[2,27],"emerging":[3],"as":[4,14,23,56,141],"powerful":[5,154],"tools":[6],"for":[7,156],"modeling":[8,157],"relationships":[9],"in":[10,32,122,191],"high-throughput":[11],"data":[12],"such":[13,22,55,140],"gene":[15,86,107,158],"expression.":[16],"Other":[17],"types":[18,95],"of":[19,30,62,83,85,96,114,132,138,169,173,181],"biological":[20,52,97,124,167],"networks,":[21,26],"protein-protein":[24],"interaction":[25],"popular":[28],"targets":[29],"study":[31],"network":[33,41,125,133,148],"theory,":[34],"and":[35,60,72,110,189],"previous":[36],"analysis":[37],"has":[38],"revealed":[39],"that":[40,129,145],"structures":[42],"identified":[43,111,177],"using":[44,104,116],"graph":[45,117],"theoretic":[46,118],"techniques":[47],"often":[48],"relate":[49],"to":[50,67,69,151,183],"certain":[51],"functions.":[53],"Structures":[54],"highly":[57],"connected":[58],"nodes":[59,63,115,170,176],"groups":[61,113],"have":[64],"been":[65],"found":[66,128],"correspond":[68],"essential":[70,142],"genes":[71,137],"protein":[73],"complexes,":[74],"respectively.":[75],"The":[76],"correlation":[77,102,147,195],"network,":[78],"which":[79],"measures":[80,131,180],"the":[81,146,166,185,192],"level":[82],"co-variation":[84],"expression":[87,108,159],"levels,":[88],"shares":[89],"some":[90,130],"structural":[91],"properties":[92,119],"with":[93],"other":[94,123],"networks.":[98],"We":[99,127],"created":[100],"several":[101],"publicly":[105],"available":[106],"data,":[109],"critical":[112],"used":[120],"previously":[121],"studies.":[126],"centrality":[134,175,182],"can":[135,149],"reveal":[136],"impact":[139,168],"genes,":[143],"suggesting":[144],"prove":[150],"be":[152],"a":[153,171],"tool":[155],"data.":[160],"In":[161],"addition,":[162],"our":[163],"method":[164],"highlights":[165],"set":[172],"high":[174],"by":[178],"combined":[179],"validate":[184],"link":[186],"between":[187],"structure":[188],"function":[190],"notoriously":[193],"noisy":[194],"network.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}