{"id":"https://openalex.org/W2160345474","doi":"https://doi.org/10.1109/bibmw.2010.5703818","title":"P-value distribution in case-control association studies","display_name":"P-value distribution in case-control association studies","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2160345474","doi":"https://doi.org/10.1109/bibmw.2010.5703818","mag":"2160345474"},"language":"en","primary_location":{"id":"doi:10.1109/bibmw.2010.5703818","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703818","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100462367","display_name":"Zhe Liu","orcid":"https://orcid.org/0000-0002-3592-3150"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Liu","raw_affiliation_strings":["Beijing Institute of Genomics, Chinese Academy and Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Genomics, Chinese Academy and Sciences, Beijing, China","institution_ids":["https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042072885","display_name":"J\u00fcrg Ott","orcid":"https://orcid.org/0000-0002-6188-1388"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jurg Ott","raw_affiliation_strings":["Beijing Institute of Genomics, Chinese Academy and Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Genomics, Chinese Academy and Sciences, Beijing, China","institution_ids":["https://openalex.org/I2801577699"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101690406","display_name":"Yuanyuan Shen","orcid":"https://orcid.org/0000-0002-8592-7723"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Shen","raw_affiliation_strings":["Beijing Institute of Genomics, Chinese Academy and Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Genomics, Chinese Academy and Sciences, Beijing, China","institution_ids":["https://openalex.org/I2801577699"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801577699"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":null,"first_page":"306","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.6781215071678162},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.6147698760032654},{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.5672178268432617},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.5541036128997803},{"id":"https://openalex.org/keywords/test-statistic","display_name":"Test statistic","score":0.5090863108634949},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.49480265378952026},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.4723416566848755},{"id":"https://openalex.org/keywords/chi-square-test","display_name":"Chi-square test","score":0.4593856632709503},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.4495566487312317},{"id":"https://openalex.org/keywords/goodness-of-fit","display_name":"Goodness of fit","score":0.43033671379089355},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.42061540484428406},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.3850817382335663},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13073939085006714},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12451478838920593}],"concepts":[{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.6781215071678162},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.6147698760032654},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.5672178268432617},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5541036128997803},{"id":"https://openalex.org/C169857963","wikidata":"https://www.wikidata.org/wiki/Q1461038","display_name":"Test statistic","level":3,"score":0.5090863108634949},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.49480265378952026},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.4723416566848755},{"id":"https://openalex.org/C32809988","wikidata":"https://www.wikidata.org/wiki/Q1071004","display_name":"Chi-square test","level":2,"score":0.4593856632709503},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4495566487312317},{"id":"https://openalex.org/C132480984","wikidata":"https://www.wikidata.org/wiki/Q2034239","display_name":"Goodness of fit","level":2,"score":0.43033671379089355},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.42061540484428406},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.3850817382335663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13073939085006714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12451478838920593},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibmw.2010.5703818","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibmw.2010.5703818","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W1972041559","https://openalex.org/W2041467022","https://openalex.org/W2098979053","https://openalex.org/W2110065044","https://openalex.org/W2113784410","https://openalex.org/W2125905177"],"related_works":["https://openalex.org/W905014826","https://openalex.org/W1587006074","https://openalex.org/W3099756376","https://openalex.org/W2031037082","https://openalex.org/W2015261284","https://openalex.org/W2342097283","https://openalex.org/W2906877126","https://openalex.org/W307809402","https://openalex.org/W2903617187","https://openalex.org/W2080121552"],"abstract_inverted_index":{"There":[0],"is":[1,35,129,144],"accumulating":[2],"evidence":[3],"that":[4,50,141],"common":[5],"traits":[6],"are":[7,66],"due":[8],"to":[9,44,53],"fairly":[10],"large":[11],"numbers":[12,85,100],"of":[13,48,86,101],"SNPs,":[14],"each":[15],"with":[16],"rather":[17],"little":[18],"contribution.":[19],"In":[20,37],"such":[21],"a":[22,42],"situation,":[23],"single-locus":[24],"methods":[25],"may":[26],"suffer":[27],"from":[28],"low":[29],"power,":[30],"especially":[31],"when":[32],"sample":[33],"size":[34],"small.":[36],"this":[38],"study,":[39],"we":[40,82,104,139],"propose":[41],"method":[43,143],"estimate":[45,96],"the":[46,84,92,97,106,110,115],"number":[47],"SNPs":[49,61],"confer":[51],"susceptibility":[52],"complex":[54],"disease.":[55],"We":[56,113],"compute":[57,105],"p-values":[58,70,87],"for":[59],"all":[60,119],"and":[62,80,89,95,109],"test":[63,124],"whether":[64],"there":[65],"significantly":[67],"more":[68],"small":[69],"than":[71,91],"expected.":[72],"For":[73],"any":[74],"given":[75],"split":[76,93,120],"point":[77],"between":[78],"0":[79],"1,":[81],"count":[83],"smaller":[88],"larger":[90],"point,":[94],"corresponding":[98,111],"expected":[99],"p-values.":[102],"Then":[103],"goodness-of-fit":[107],"chi-square":[108],"z-score.":[112],"define":[114],"maximal":[116],"z-score":[117],"across":[118],"points":[121],"as":[122],"our":[123,142],"statistic,":[125],"whose":[126],"significance":[127],"level":[128],"evaluated":[130],"by":[131],"permutation":[132],"tests.":[133],"By":[134],"analyzing":[135],"two":[136],"real":[137],"datasets,":[138],"demonstrate":[140],"promising":[145],"in":[146],"case-control":[147],"association":[148],"studies.":[149]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
