{"id":"https://openalex.org/W7126054861","doi":"https://doi.org/10.1109/bibm66473.2025.11356048","title":"Medical Knowledge-Guided CLIP Adaptation for Fundus Image Diagnosis","display_name":"Medical Knowledge-Guided CLIP Adaptation for Fundus Image Diagnosis","publication_year":2025,"publication_date":"2025-12-15","ids":{"openalex":"https://openalex.org/W7126054861","doi":"https://doi.org/10.1109/bibm66473.2025.11356048"},"language":null,"primary_location":{"id":"doi:10.1109/bibm66473.2025.11356048","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356048","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124292499","display_name":"Shaolong Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaolong Wang","raw_affiliation_strings":["College of Computer Science &#x0026; Software Engineering, Shenzhen University,Shenzhen,China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science &#x0026; Software Engineering, Shenzhen University,Shenzhen,China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103264712","display_name":"Xinyu Zhao","orcid":"https://orcid.org/0000-0003-1422-5203"},"institutions":[{"id":"https://openalex.org/I4210154929","display_name":"He Eye Hospital","ror":"https://ror.org/04fnhr972","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154929"]},{"id":"https://openalex.org/I4210159816","display_name":"Shandong Eye Hospital","ror":"https://ror.org/05htkf588","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhao","raw_affiliation_strings":["Shenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University,Shenzhen,China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University,Shenzhen,China","institution_ids":["https://openalex.org/I4210154929","https://openalex.org/I4210159816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064242236","display_name":"Zhenquan Wu","orcid":"https://orcid.org/0000-0003-4108-3001"},"institutions":[{"id":"https://openalex.org/I4210154929","display_name":"He Eye Hospital","ror":"https://ror.org/04fnhr972","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154929"]},{"id":"https://openalex.org/I4210159816","display_name":"Shandong Eye Hospital","ror":"https://ror.org/05htkf588","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenquan Wu","raw_affiliation_strings":["Shenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University,Shenzhen,China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University,Shenzhen,China","institution_ids":["https://openalex.org/I4210154929","https://openalex.org/I4210159816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124194497","display_name":"Guoming Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154929","display_name":"He Eye Hospital","ror":"https://ror.org/04fnhr972","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154929"]},{"id":"https://openalex.org/I4210159816","display_name":"Shandong Eye Hospital","ror":"https://ror.org/05htkf588","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoming Zhang","raw_affiliation_strings":["Shenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University,Shenzhen,China"],"affiliations":[{"raw_affiliation_string":"Shenzhen Eye Hospital, Shenzhen Eye Institute, Jinan University,Shenzhen,China","institution_ids":["https://openalex.org/I4210154929","https://openalex.org/I4210159816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101716205","display_name":"Tianfu Wang","orcid":"https://orcid.org/0000-0001-6644-7233"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I3131625388","display_name":"University Town of Shenzhen","ror":"https://ror.org/05f5j6225","country_code":"CN","type":"education","lineage":["https://openalex.org/I3131625388"]},{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianfu Wang","raw_affiliation_strings":["School of Biomedical engineering &#x0026; Shenzhen University Medical School, Shenzhen University,Shenzhen,China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical engineering &#x0026; Shenzhen University Medical School, Shenzhen University,Shenzhen,China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I3131625388","https://openalex.org/I4210145292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111337419","display_name":"BaiYing Lei","orcid":null},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I3131625388","display_name":"University Town of Shenzhen","ror":"https://ror.org/05f5j6225","country_code":"CN","type":"education","lineage":["https://openalex.org/I3131625388"]},{"id":"https://openalex.org/I4210145292","display_name":"Shenzhen University Health Science Center","ror":"https://ror.org/04yjbr930","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210145292"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baiying Lei","raw_affiliation_strings":["School of Biomedical engineering &#x0026; Shenzhen University Medical School, Shenzhen University,Shenzhen,China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical engineering &#x0026; Shenzhen University Medical School, Shenzhen University,Shenzhen,China","institution_ids":["https://openalex.org/I180726961","https://openalex.org/I3131625388","https://openalex.org/I4210145292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5124292499"],"corresponding_institution_ids":["https://openalex.org/I180726961"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71095054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4220","last_page":"4223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.7458000183105469,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.7458000183105469,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11307","display_name":"Domain Adaptation and Few-Shot Learning","score":0.07410000264644623,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11714","display_name":"Multimodal Machine Learning Applications","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fundus","display_name":"Fundus (uterus)","score":0.5940999984741211},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.5386999845504761},{"id":"https://openalex.org/keywords/terminology","display_name":"Terminology","score":0.45509999990463257},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.42289999127388},{"id":"https://openalex.org/keywords/medical-imaging","display_name":"Medical imaging","score":0.3824000060558319},{"id":"https://openalex.org/keywords/domain-adaptation","display_name":"Domain adaptation","score":0.3601999878883362}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6597999930381775},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.61080002784729},{"id":"https://openalex.org/C2776391266","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Fundus (uterus)","level":2,"score":0.5940999984741211},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5386999845504761},{"id":"https://openalex.org/C547195049","wikidata":"https://www.wikidata.org/wiki/Q1725664","display_name":"Terminology","level":2,"score":0.45509999990463257},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.42820000648498535},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.42289999127388},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.3824000060558319},{"id":"https://openalex.org/C2776434776","wikidata":"https://www.wikidata.org/wiki/Q19246213","display_name":"Domain adaptation","level":3,"score":0.3601999878883362},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.33970001339912415},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C75294576","wikidata":"https://www.wikidata.org/wiki/Q5165192","display_name":"Contextual image classification","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.26100000739097595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25369998812675476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm66473.2025.11356048","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm66473.2025.11356048","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4","score":0.43332138657569885}],"awards":[{"id":"https://openalex.org/G4862866531","display_name":null,"funder_award_id":"SZSM202311018","funder_id":"https://openalex.org/F4320335767","funder_display_name":"Sanming Project of Medicine in Shenzhen"},{"id":"https://openalex.org/G5262655625","display_name":null,"funder_award_id":"JCYJ20240813152703005,JCYJ20241202124202004,JCYJ20240813142111015","funder_id":"https://openalex.org/F4320336569","funder_display_name":"Shenzhen Science and Technology Innovation Program"},{"id":"https://openalex.org/G6520292948","display_name":null,"funder_award_id":"82271103,82401315,82301269","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335767","display_name":"Sanming Project of Medicine in Shenzhen","ror":null},{"id":"https://openalex.org/F4320336569","display_name":"Shenzhen Science and Technology Innovation Program","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W3164581645","https://openalex.org/W3198377975","https://openalex.org/W4313175608","https://openalex.org/W4322766882","https://openalex.org/W4361857100","https://openalex.org/W4382393818","https://openalex.org/W4386065763","https://openalex.org/W4386790226","https://openalex.org/W4400920541","https://openalex.org/W4403891519","https://openalex.org/W4404486497","https://openalex.org/W4407218144","https://openalex.org/W7103752455"],"related_works":[],"abstract_inverted_index":{"Fundus":[0],"image":[1,51,87],"classification":[2,88],"plays":[3],"a":[4,46,81,101,120,134],"crucial":[5],"role":[6],"in":[7,156],"diagnosing":[8],"ophthalmic":[9],"diseases":[10],"but":[11],"remains":[12],"challenging":[13],"due":[14],"to":[15,58,70,109,124],"the":[16,22,111],"scarcity":[17],"of":[18,24,114],"annotated":[19],"data":[20],"and":[21,68,129,132],"subtlety":[23],"lesion":[25],"features,":[26],"which":[27],"often":[28],"resemble":[29],"surrounding":[30],"tissues.":[31],"Vision-language":[32],"models":[33,57],"(VLMs),":[34],"known":[35],"for":[36,49,84,137],"their":[37],"impressive":[38],"few-shot":[39,85,158],"learning":[40,94],"performance":[41],"on":[42],"natural":[43],"images,":[44],"offer":[45],"promising":[47],"foundation":[48],"medical":[50,59,91,115],"analysis.":[52],"However,":[53],"directly":[54],"applying":[55],"these":[56,77],"tasks":[60],"is":[61],"suboptimal,":[62],"as":[63],"they":[64],"lack":[65],"domain-specific":[66,102],"knowledge":[67],"struggle":[69],"capture":[71],"fine-grained":[72],"pathology":[73],"cues.":[74],"To":[75],"address":[76],"challenges,":[78],"we":[79,118],"propose":[80],"novel":[82],"framework":[83],"fundus":[86],"that":[89,147],"integrates":[90],"knowledge-driven":[92],"prompt":[93,103],"into":[95],"CLIP.":[96],"Specifically,":[97],"our":[98,148],"method":[99],"utilizes":[100],"bank":[104],"constructed":[105],"from":[106],"clinical":[107],"terminology":[108],"enrich":[110],"model's":[112],"understanding":[113],"context.":[116],"Additionally,":[117],"introduce":[119],"cross-modal":[121],"alignment":[122],"loss":[123],"improve":[125],"consistency":[126],"between":[127],"visual":[128],"textual":[130],"features":[131],"employ":[133],"lightweight":[135],"adapter":[136],"efficient":[138],"task-specific":[139],"fine-tuning.":[140],"Extensive":[141],"experiments":[142],"across":[143],"multiple":[144],"datasets":[145],"demonstrate":[146],"approach":[149],"significantly":[150],"enhances":[151],"performance,":[152],"surpassing":[153],"existing":[154],"methods":[155],"various":[157],"scenarios.":[159]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2026-01-30T00:00:00"}
