{"id":"https://openalex.org/W4205813517","doi":"https://doi.org/10.1109/bibm52615.2021.9669275","title":"Computational Prediction of Biological Signatures for Candidate Driver Genes Associated with Ovarian Cancer","display_name":"Computational Prediction of Biological Signatures for Candidate Driver Genes Associated with Ovarian Cancer","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4205813517","doi":"https://doi.org/10.1109/bibm52615.2021.9669275"},"language":"en","primary_location":{"id":"doi:10.1109/bibm52615.2021.9669275","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669275","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005732540","display_name":"Daniel Lin","orcid":"https://orcid.org/0000-0002-6203-712X"},"institutions":[{"id":"https://openalex.org/I2799350140","display_name":"Fairview School District","ror":"https://ror.org/01xddfn70","country_code":"US","type":"education","lineage":["https://openalex.org/I2799350140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Lin","raw_affiliation_strings":["Fairview High School, Boulder, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fairview High School, Boulder, USA","institution_ids":["https://openalex.org/I2799350140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026503361","display_name":"Renata Fu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134570","display_name":"Scarsdale Public Schools","ror":"https://ror.org/042w3r845","country_code":"US","type":"education","lineage":["https://openalex.org/I4210134570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renata Fu","raw_affiliation_strings":["Scarsdale High School, Scarsdale, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scarsdale High School, Scarsdale, USA","institution_ids":["https://openalex.org/I4210134570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023085664","display_name":"Ellie Xi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129168","display_name":"BASIS International (United States)","ror":"https://ror.org/03q4sef08","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129168"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellie Xi","raw_affiliation_strings":["BASIS Independent Silicon Valley, Cupertino, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASIS Independent Silicon Valley, Cupertino, USA","institution_ids":["https://openalex.org/I4210129168"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063946766","display_name":"Yongsheng Bai","orcid":"https://orcid.org/0000-0002-9944-5426"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongsheng Bai","raw_affiliation_strings":["NGIST, Ann Arbor, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NGIST, Ann Arbor, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5203,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56610801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"47","issue":null,"first_page":"2437","last_page":"2442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.8124789595603943},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7543405294418335},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7391422986984253},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.529771089553833},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.4750411808490753},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4596315324306488},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4083159267902374},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3837220370769501},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.382680207490921},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.35383889079093933},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.34711965918540955},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34520551562309265},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3243919610977173},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1284129023551941}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.8124789595603943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7543405294418335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7391422986984253},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.529771089553833},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4750411808490753},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4596315324306488},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4083159267902374},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3837220370769501},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.382680207490921},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.35383889079093933},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.34711965918540955},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34520551562309265},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3243919610977173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1284129023551941}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm52615.2021.9669275","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm52615.2021.9669275","pdf_url":null,"source":{"id":"https://openalex.org/S4363607735","display_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.49000000953674316,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2004589024","https://openalex.org/W2037993016","https://openalex.org/W2115894077","https://openalex.org/W2132926880","https://openalex.org/W2133465414","https://openalex.org/W2153544371","https://openalex.org/W2158217645","https://openalex.org/W2559191318","https://openalex.org/W2900569176","https://openalex.org/W2945274796","https://openalex.org/W2969718750","https://openalex.org/W2974193113","https://openalex.org/W3038084551","https://openalex.org/W3045999631","https://openalex.org/W3082390367","https://openalex.org/W3096828292","https://openalex.org/W3139511935","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W1964572291","https://openalex.org/W4387948744","https://openalex.org/W1987520879","https://openalex.org/W184793361","https://openalex.org/W2352732738","https://openalex.org/W2123060905","https://openalex.org/W2559588208","https://openalex.org/W1984964356","https://openalex.org/W2297026197","https://openalex.org/W2065112873"],"abstract_inverted_index":{"Ovarian":[0],"cancer":[1,7,18,49,66,129,183],"is":[2],"a":[3,27],"prominent":[4],"cause":[5],"of":[6,16,26,73,102,124],"deaths":[8,15],"among":[9],"women,":[10],"accounting":[11],"for":[12,137,217],"the":[13,20,58,70,111,122,172,177],"most":[14],"any":[17],"in":[19,29,110],"female":[21],"reproductive":[22],"system.":[23],"The":[24,85,99,140],"functions":[25],"gene":[28],"ovarian":[30,48,65,113,128,182],"tissue":[31],"are":[32,43,106],"affected":[33],"by":[34,144],"its":[35],"expression":[36,60],"level.":[37],"Oncogenes":[38],"and":[39,50,81,94,154,214],"tumor":[40],"suppressor":[41],"genes":[42,56,72,88,104,120,126,156,170,188],"often":[44],"differentially":[45],"expressed":[46,109],"between":[47],"normal":[51,112],"tissues.":[52],"We":[53,76,185],"selected":[54,136],"50":[55],"with":[57,91,127,159],"highest":[59],"values":[61],"based":[62],"on":[63,150,167,181],"TCGA":[64],"RNA-seq":[67],"data":[68],"as":[69,115,117],"input":[71,125],"this":[74],"study.":[75],"then":[77],"conducted":[78],"protein-protein":[79],"interaction":[80],"functional":[82],"annotation":[83],"analysis.":[84,219],"43":[86,103],"interacted":[87],"were":[89,135,157],"enriched":[90],"11":[92],"GO":[93],"13":[95],"KEGG":[96],"Pathway":[97],"terms.":[98],"22":[100],"out":[101],"that":[105,210],"not":[107],"highly":[108],"tissue,":[114],"well":[116],"12":[118],"other":[119],"from":[121,132],"list":[123],"association":[130],"reported":[131,186],"published":[133],"literature,":[134],"further":[138],"investigation.":[139],"Multiple":[141],"Sequence":[142],"Comparison":[143],"Log-Expectation":[145],"(MUSCLE)":[146],"tool":[147],"was":[148,165],"run":[149],"those":[151],"34":[152,168],"genes,":[153],"all":[155],"associated":[158],"conserved":[160],"domains.":[161],"Finally,":[162],"survival":[163,218],"analysis":[164],"performed":[166],"candidate":[169],"using":[171],"Kaplan-Meier":[173],"Plotter":[174],"to":[175],"evaluate":[176],"impact":[178],"they":[179],"have":[180],"progression.":[184],"21":[187],"(C3,":[189],"CLU,":[190],"COLIAI,":[191],"COLlA2,":[192],"COL3A1,":[193],"CTCFL,":[194],"FN1,":[195],"HSPAS,":[196],"IGF2,":[197],"PSAP,":[198],"SPARC,":[199],"TUBB,":[200],"ALDOA,":[201],"GAPDH,":[202],"HSP90AB1,":[203],"PKM,":[204],"RPLP0,":[205],"RPLPI,":[206],"RPS4,":[207],"RPS6,":[208],"UBC)":[209],"had":[211],"domain":[212],"conservation":[213],"significant":[215],"p-values":[216]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}