{"id":"https://openalex.org/W3128679163","doi":"https://doi.org/10.1109/bibm49941.2020.9312983","title":"A Nonparametric Method for Detecting Differential DNA Methylation Regions","display_name":"A Nonparametric Method for Detecting Differential DNA Methylation Regions","publication_year":2020,"publication_date":"2020-12-16","ids":{"openalex":"https://openalex.org/W3128679163","doi":"https://doi.org/10.1109/bibm49941.2020.9312983","mag":"3128679163"},"language":"en","primary_location":{"id":"doi:10.1109/bibm49941.2020.9312983","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9312983","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054219637","display_name":"Xifang Sun","orcid":"https://orcid.org/0000-0002-5739-4624"},"institutions":[{"id":"https://openalex.org/I181903023","display_name":"Xi'an Shiyou University","ror":"https://ror.org/040c7js64","country_code":"CN","type":"education","lineage":["https://openalex.org/I181903023"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xifang Sun","raw_affiliation_strings":["School of Science, Xi\u2019an Shiyou University, Xi\u2019an, Shaanxi, P.R. China","School of Science, Xi'an Shiyou University, Xi'an, Shaanxi, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, Xi\u2019an Shiyou University, Xi\u2019an, Shaanxi, P.R. China","institution_ids":["https://openalex.org/I181903023"]},{"raw_affiliation_string":"School of Science, Xi'an Shiyou University, Xi'an, Shaanxi, P.R. China","institution_ids":["https://openalex.org/I181903023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044756168","display_name":"Jiaqiang Zhu","orcid":"https://orcid.org/0000-0002-1455-0041"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaqiang Zhu","raw_affiliation_strings":["School of Public Health, University of Michigan, Ann Arbor, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, University of Michigan, Ann Arbor, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048884064","display_name":"Shiquan Sun","orcid":"https://orcid.org/0000-0002-9150-6992"},"institutions":[{"id":"https://openalex.org/I271893122","display_name":"National Health and Family Planning Commission","ror":"https://ror.org/052eegr76","country_code":"CN","type":"government","lineage":["https://openalex.org/I271893122","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiquan Sun","raw_affiliation_strings":["Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission; School of Public Health, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, P.R. China","School of Public Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China","Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission; School of Public Health, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, P.R. China","institution_ids":["https://openalex.org/I271893122","https://openalex.org/I87445476"]},{"raw_affiliation_string":"School of Public Health, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission","institution_ids":["https://openalex.org/I271893122"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1668","last_page":"1671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.96670001745224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6541088819503784},{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.5722204446792603},{"id":"https://openalex.org/keywords/nonparametric-statistics","display_name":"Nonparametric statistics","score":0.5567206144332886},{"id":"https://openalex.org/keywords/bioconductor","display_name":"Bioconductor","score":0.4995110034942627},{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"Differentially methylated regions","score":0.49175432324409485},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4532117545604706},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44681811332702637},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.44093257188796997},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4163754880428314},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.40172791481018066},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.37650492787361145},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27698323130607605},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.25293511152267456},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2108081579208374},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11394810676574707},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.10905599594116211}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6541088819503784},{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.5722204446792603},{"id":"https://openalex.org/C102366305","wikidata":"https://www.wikidata.org/wiki/Q1097688","display_name":"Nonparametric statistics","level":2,"score":0.5567206144332886},{"id":"https://openalex.org/C2779694297","wikidata":"https://www.wikidata.org/wiki/Q2888953","display_name":"Bioconductor","level":3,"score":0.4995110034942627},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.49175432324409485},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4532117545604706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44681811332702637},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.44093257188796997},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4163754880428314},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.40172791481018066},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.37650492787361145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27698323130607605},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.25293511152267456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2108081579208374},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11394810676574707},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.10905599594116211}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm49941.2020.9312983","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm49941.2020.9312983","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4286742095","https://openalex.org/W2054523001","https://openalex.org/W4392757366","https://openalex.org/W3216681881","https://openalex.org/W4286221465","https://openalex.org/W4304845486","https://openalex.org/W4390618299","https://openalex.org/W2055679485","https://openalex.org/W4400842958","https://openalex.org/W2030960893"],"abstract_inverted_index":{"DNA":[0],"methylation":[1,27,44],"has":[2],"long":[3],"been":[4,110],"known":[5],"as":[6],"an":[7],"epigenetic":[8],"gene":[9],"silencing":[10],"mechanism.":[11],"For":[12],"a":[13,24,40,101,124,184,190,209],"motivating":[14],"example,":[15],"the":[16,63,66,151,159,165],"methylomes":[17],"of":[18,26,32,42,68,104,153,168,192,211],"cancer":[19,33],"and":[20,134,138,164,180,195],"non-cancer":[21],"cells":[22,34],"show":[23],"number":[25,67,103],"differences,":[28],"indicating":[29],"that":[30,130],"some":[31],"'":[35],"aggressive":[36],"properties":[37],"could":[38,54],"be":[39],"result":[41],"certain":[43],"features.":[45],"Robust":[46],"methods":[47,70,97,108],"for":[48,72,90],"detecting":[49,73],"differentially":[50],"methylated":[51],"regions":[52,61,173],"(DMRs)":[53],"help":[55],"scientists":[56],"narrow":[57],"down":[58],"biologically":[59],"important":[60],"in":[62],"genome.":[64],"Despite":[65],"statistical":[69],"developed":[71],"DMR,":[74],"there":[75],"is":[76,85,88,131,162],"no":[77],"default":[78],"or":[79],"strongest":[80],"method.":[81],"Fisher's":[82],"exact":[83],"test":[84],"direct,":[86],"but":[87,112],"inadequate":[89],"data":[91],"with":[92,100],"multiple":[93],"replications,":[94],"while":[95],"regression-based":[96],"often":[98,115],"come":[99],"large":[102],"assumptions.":[105],"More":[106],"complicated":[107],"have":[109],"proposed,":[111],"those":[113],"are":[114,174],"difficult":[116],"to":[117,136,149,200,207],"interpret.":[118,139],"In":[119],"this":[120],"paper,":[121],"we":[122,204],"propose":[123],"three-step":[125],"nonparametric":[126],"kernel":[127],"smoothing":[128],"method":[129,142,148],"both":[132],"flexible":[133],"straightforward":[135],"implement":[137],"The":[140,171],"proposed":[141],"relies":[143],"on":[144,183,214],"local":[145],"quadratic":[146],"fitting":[147],"find":[150],"set":[152,167],"equilibrium":[154],"points":[155],"(points":[156],"at":[157],"which":[158],"first":[160],"derivative":[161],"0)":[163],"corresponding":[166],"confidence":[169],"windows.":[170],"potential":[172],"further":[175],"refined":[176],"using":[177],"biological":[178],"criteria,":[179],"selected":[181],"based":[182],"Bonferroni":[185],"adjusted":[186],"t-test":[187],"cutoff.":[188],"Using":[189],"comparison":[191],"three":[193,196],"senescent":[194],"proliferating":[197],"cell":[198],"lines":[199],"illustrate":[201],"our":[202],"method,":[203],"were":[205],"able":[206],"identify":[208],"total":[210],"1,077":[212],"DMRs":[213],"chromosome":[215],"21.":[216]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
