{"id":"https://openalex.org/W2089167752","doi":"https://doi.org/10.1109/bibm.2010.5706584","title":"Correlating CpG islands, motifs, and sequence variants in human chromosome 21","display_name":"Correlating CpG islands, motifs, and sequence variants in human chromosome 21","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2089167752","doi":"https://doi.org/10.1109/bibm.2010.5706584","mag":"2089167752"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2010.5706584","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706584","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046680281","display_name":"Leah Spontaneo","orcid":null},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Leah Spontaneo","raw_affiliation_strings":["Department of Computer Science and Engineering, York University, Toronto, ONT, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, York University, Toronto, ONT, Canada","institution_ids":["https://openalex.org/I192455969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105530330","display_name":"Nick Cercone","orcid":null},"institutions":[{"id":"https://openalex.org/I192455969","display_name":"York University","ror":"https://ror.org/05fq50484","country_code":"CA","type":"education","lineage":["https://openalex.org/I192455969"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nick Cercone","raw_affiliation_strings":["Department of Computer Science and Engineering, York University, Toronto, ONT, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, York University, Toronto, ONT, Canada","institution_ids":["https://openalex.org/I192455969"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046680281"],"corresponding_institution_ids":["https://openalex.org/I192455969"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12071718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"58","issue":null,"first_page":"319","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.8236002922058105},{"id":"https://openalex.org/keywords/hidden-markov-model","display_name":"Hidden Markov model","score":0.6936618685722351},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6042534112930298},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.529973030090332},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5184499621391296},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5117146968841553},{"id":"https://openalex.org/keywords/viterbi-algorithm","display_name":"Viterbi algorithm","score":0.49617132544517517},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4891872704029083},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4582566022872925},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4410698711872101},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.4306851029396057},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.4274093508720398},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.4199620187282562},{"id":"https://openalex.org/keywords/sequence-motif","display_name":"Sequence motif","score":0.41736796498298645},{"id":"https://openalex.org/keywords/methylated-dna-immunoprecipitation","display_name":"Methylated DNA immunoprecipitation","score":0.41297560930252075},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4119628667831421},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4051643908023834},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.34681236743927},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2072206735610962},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09573093056678772}],"concepts":[{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.8236002922058105},{"id":"https://openalex.org/C23224414","wikidata":"https://www.wikidata.org/wiki/Q176769","display_name":"Hidden Markov model","level":2,"score":0.6936618685722351},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6042534112930298},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.529973030090332},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5184499621391296},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5117146968841553},{"id":"https://openalex.org/C60582962","wikidata":"https://www.wikidata.org/wiki/Q83886","display_name":"Viterbi algorithm","level":3,"score":0.49617132544517517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4891872704029083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4582566022872925},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4410698711872101},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4306851029396057},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4274093508720398},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4199620187282562},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.41736796498298645},{"id":"https://openalex.org/C116114238","wikidata":"https://www.wikidata.org/wiki/Q6823960","display_name":"Methylated DNA immunoprecipitation","level":5,"score":0.41297560930252075},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4119628667831421},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4051643908023834},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.34681236743927},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2072206735610962},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09573093056678772}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2010.5706584","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706584","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","score":0.8899999856948853,"display_name":"Life below water"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1815199292","https://openalex.org/W1964621256","https://openalex.org/W1967841068","https://openalex.org/W1984959915","https://openalex.org/W1993848554","https://openalex.org/W2025898521","https://openalex.org/W2032715537","https://openalex.org/W2036078075","https://openalex.org/W2040149948","https://openalex.org/W2052581001","https://openalex.org/W2081589784","https://openalex.org/W2084748297","https://openalex.org/W2090515073","https://openalex.org/W2103148772","https://openalex.org/W2106034419","https://openalex.org/W2115992869","https://openalex.org/W2130202009","https://openalex.org/W2147658756","https://openalex.org/W2161399316","https://openalex.org/W2164814636","https://openalex.org/W2914577469","https://openalex.org/W6683848113"],"related_works":["https://openalex.org/W1480390089","https://openalex.org/W2348998951","https://openalex.org/W2436825352","https://openalex.org/W2163125553","https://openalex.org/W2033244804","https://openalex.org/W4210257611","https://openalex.org/W2579951821","https://openalex.org/W4233664389","https://openalex.org/W2127540087","https://openalex.org/W2008284862"],"abstract_inverted_index":{"CpG":[0],"islands":[1],"are":[2,123],"important":[3],"regions":[4],"in":[5,57],"DNA.":[6],"They":[7],"usually":[8],"appear":[9],"at":[10],"the":[11,45,60,68,84,89,92,116],"5'":[12],"end":[13],"of":[14,59,111,118],"genes":[15],"containing":[16],"GC-rich":[17],"dinucleotides.":[18],"When":[19],"DNA":[20],"methylation":[21],"occurs,":[22],"gene":[23],"regulation":[24],"is":[25,94],"affected":[26],"and":[27,65,70,87,113,120,134,140],"it":[28],"sometimes":[29],"leads":[30],"to":[31,75,78],"carcinogenesis.":[32],"We":[33],"propose":[34],"a":[35,40,51,80,109],"new":[36],"detection":[37,63,69],"program":[38,74],"using":[39,138],"hidden":[41],"Markov":[42],"model":[43],"alongside":[44],"Viterbi":[46],"algorithm.":[47],"Our":[48],"solution":[49],"provides":[50],"graphical":[52],"user":[53],"interface":[54],"not":[55],"seen":[56],"many":[58],"other":[61],"CGI":[62,136],"programs":[64],"we":[66,104,127],"unify":[67],"analysis":[71,107],"under":[72],"one":[73],"allow":[76],"researchers":[77],"scan":[79,93],"genetic":[81],"sequence,":[82],"detect":[83],"significant":[85],"CGIs,":[86],"analyze":[88],"sequence":[90],"once":[91],"complete":[95],"for":[96],"any":[97],"noteworthy":[98],"findings.":[99],"Using":[100],"human":[101],"chromosome":[102],"21,":[103],"run":[105],"an":[106],"on":[108],"dataset":[110],"promoters":[112,137],"discover":[114],"that":[115],"characteristics":[117],"methylated":[119,133],"unmethylated":[121,135],"CGIs":[122],"significantly":[124,129],"different.":[125],"Finally,":[126],"detected":[128],"different":[130],"motifs":[131],"between":[132],"MEME":[139],"MAST.":[141]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}