{"id":"https://openalex.org/W2094481611","doi":"https://doi.org/10.1109/bibm.2010.5706581","title":"Stochastic gene expression modeling with hill function for switch-like gene responses","display_name":"Stochastic gene expression modeling with hill function for switch-like gene responses","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2094481611","doi":"https://doi.org/10.1109/bibm.2010.5706581","mag":"2094481611"},"language":"en","primary_location":{"id":"doi:10.1109/bibm.2010.5706581","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031799596","display_name":"Haseong Kim","orcid":"https://orcid.org/0000-0002-4594-5791"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Haseong Kim","raw_affiliation_strings":["Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College London, London, UK","Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College, London, UK"],"affiliations":[{"raw_affiliation_string":"Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074413858","display_name":"Erol Gelenbe","orcid":"https://orcid.org/0000-0001-9688-2201"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Erol Gelenbe","raw_affiliation_strings":["Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College London, London, UK","Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College, London, UK"],"affiliations":[{"raw_affiliation_string":"Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Intelligent Systems and Networks Group, Department of Electrical and Electronic Engineering, Imperial College, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031799596"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.12358517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"403","issue":null,"first_page":"302","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.6807677149772644},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6289980411529541},{"id":"https://openalex.org/keywords/stochastic-modelling","display_name":"Stochastic modelling","score":0.5942700505256653},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5849566459655762},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5643379092216492},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5530128479003906},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.5491625070571899},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5214171409606934},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.49452635645866394},{"id":"https://openalex.org/keywords/stochastic-process","display_name":"Stochastic process","score":0.45472896099090576},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4357205033302307},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3628808259963989},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24882465600967407},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14722031354904175}],"concepts":[{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6807677149772644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6289980411529541},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.5942700505256653},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5849566459655762},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5643379092216492},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5530128479003906},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5491625070571899},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5214171409606934},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.49452635645866394},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.45472896099090576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4357205033302307},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3628808259963989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24882465600967407},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14722031354904175},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibm.2010.5706581","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibm.2010.5706581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2010 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1499965417","https://openalex.org/W1978319180","https://openalex.org/W1978329448","https://openalex.org/W2015970511","https://openalex.org/W2018435536","https://openalex.org/W2031822229","https://openalex.org/W2032663983","https://openalex.org/W2034665579","https://openalex.org/W2034785760","https://openalex.org/W2036305210","https://openalex.org/W2058221907","https://openalex.org/W2062404235","https://openalex.org/W2065515536","https://openalex.org/W2096705138","https://openalex.org/W2105640293","https://openalex.org/W2107515727","https://openalex.org/W2122121413","https://openalex.org/W2123511816","https://openalex.org/W2130059696","https://openalex.org/W2134759932","https://openalex.org/W2156781574","https://openalex.org/W2160845585","https://openalex.org/W2167154952","https://openalex.org/W2611370172"],"related_works":["https://openalex.org/W2010571965","https://openalex.org/W2002709996","https://openalex.org/W3128451840","https://openalex.org/W4387092964","https://openalex.org/W2103471012","https://openalex.org/W2966064480","https://openalex.org/W2115810854","https://openalex.org/W2380236774","https://openalex.org/W2042280983","https://openalex.org/W4291672717"],"abstract_inverted_index":{"Gene":[0],"expression":[1,30,60,86],"models":[2,43,175],"play":[3],"a":[4,57,121],"key":[5],"role":[6],"to":[7,26,39,75],"understand":[8],"the":[9,28,32,41,46,65,76,105,111,128,131,134,142,146,164],"mechanisms":[10],"of":[11,49,68,84,114,130,133,148,168],"gene":[12,29,50,59,69,85,115,178],"regulation":[13],"whose":[14],"aspects":[15],"are":[16,93],"grade":[17],"and":[18,87,180],"switch-like":[19,47,66,112,177],"responses.":[20,51],"Though":[21],"many":[22],"stochastic":[23,42,58,172],"approaches":[24],"attempt":[25],"explain":[27,45],"mechanisms,":[31],"Gillespie":[33,78,107],"algorithm":[34,108],"which":[35,62,117,161],"is":[36,118,138],"commonly":[37],"used":[38],"simulate":[40],"hardly":[44],"behaviors":[48,67,113],"In":[52,158],"this":[53],"study,":[54],"we":[55],"propose":[56],"model":[61,102,137],"can":[63,162],"describe":[64],"responses":[70],"by":[71],"employing":[72],"Hill":[73,143],"functions":[74],"conventional":[77],"algorithm.":[79],"We":[80,125],"assume":[81],"eight":[82],"processes":[83],"their":[88,152],"biologically":[89],"appropriate":[90],"reaction":[91],"rates":[92],"estimated":[94],"based":[95],"on":[96],"published":[97,122],"literatures.":[98],"Our":[99],"negative":[100],"regulatory":[101],"shows":[103],"that":[104,127],"modified":[106],"successfully":[109,174],"describes":[110],"responses,":[116],"consistent":[119],"with":[120],"experimental":[123],"study.":[124],"observe":[126],"state":[129],"system":[132,160],"toggled":[135],"switch":[136],"rarely":[139],"changed":[140],"since":[141],"function":[144],"prevents":[145],"activation":[147],"involved":[149],"proteins":[150],"when":[151],"concentrations":[153],"stay":[154],"at":[155],"low":[156],"level.":[157],"ScbA/ScbR":[159],"control":[163],"antibiotic":[165],"metabolite":[166],"production":[167],"microorganisms,":[169],"our":[170],"proposed":[171],"approach":[173],"its":[176],"response":[179],"oscillatory":[181],"expressions.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
