{"id":"https://openalex.org/W4417250986","doi":"https://doi.org/10.1109/bibe66822.2025.00119","title":"Multi-Stage Classification Approach for Heart Failure Disease Diagnosis and Reduced Ejection Fraction Prediction","display_name":"Multi-Stage Classification Approach for Heart Failure Disease Diagnosis and Reduced Ejection Fraction Prediction","publication_year":2025,"publication_date":"2025-11-06","ids":{"openalex":"https://openalex.org/W4417250986","doi":"https://doi.org/10.1109/bibe66822.2025.00119"},"language":null,"primary_location":{"id":"doi:10.1109/bibe66822.2025.00119","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe66822.2025.00119","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 25th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092556821","display_name":"Ognjen Pavi\u0107","orcid":"https://orcid.org/0000-0003-2533-1079"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Ognjen Pavi\u0107","raw_affiliation_strings":["Institute for Information Technologies, University of Kragujevac, Bioengineering Research and Development Center Kragujevac,Kragujevac,Serbia"],"affiliations":[{"raw_affiliation_string":"Institute for Information Technologies, University of Kragujevac, Bioengineering Research and Development Center Kragujevac,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022942714","display_name":"Lazar Da\u0161i\u0107","orcid":"https://orcid.org/0000-0002-8055-100X"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Lazar Da\u0161i\u0107","raw_affiliation_strings":["Institute for Information Technologies, University of Kragujevac, Bioengineering Research and Development Center Kragujevac,Kragujevac,Serbia"],"affiliations":[{"raw_affiliation_string":"Institute for Information Technologies, University of Kragujevac, Bioengineering Research and Development Center Kragujevac,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002561054","display_name":"An\u0111ela Blagojevi\u0107","orcid":"https://orcid.org/0000-0002-8652-3827"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"An\u0111ela Blagojevi\u0107","raw_affiliation_strings":["University of Kragujevac, Bioengineering Research and Development Center,Faculty of Engineering,Kragujevac,Serbia"],"affiliations":[{"raw_affiliation_string":"University of Kragujevac, Bioengineering Research and Development Center,Faculty of Engineering,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008564157","display_name":"Tijana Geroski","orcid":"https://orcid.org/0000-0003-1417-0521"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Tijana Geroski","raw_affiliation_strings":["University of Kragujevac, Bioengineering Research and Development Center,Faculty of Engineering,Kragujevac,Serbia"],"affiliations":[{"raw_affiliation_string":"University of Kragujevac, Bioengineering Research and Development Center,Faculty of Engineering,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006131395","display_name":"Nenad Filipovi\u0107","orcid":"https://orcid.org/0000-0001-9964-5615"},"institutions":[{"id":"https://openalex.org/I14245010","display_name":"University of Kragujevac","ror":"https://ror.org/04f7vj627","country_code":"RS","type":"education","lineage":["https://openalex.org/I14245010"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Nenad Filipovi\u0107","raw_affiliation_strings":["University of Kragujevac, Bioengineering Research and Development Center,Faculty of Engineering,Kragujevac,Serbia"],"affiliations":[{"raw_affiliation_string":"University of Kragujevac, Bioengineering Research and Development Center,Faculty of Engineering,Kragujevac,Serbia","institution_ids":["https://openalex.org/I14245010"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5092556821"],"corresponding_institution_ids":["https://openalex.org/I14245010"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55790877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"687","last_page":"692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.5156999826431274,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.5156999826431274,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.1451999992132187,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ejection-fraction","display_name":"Ejection fraction","score":0.9093999862670898},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.7027000188827515},{"id":"https://openalex.org/keywords/fraction","display_name":"Fraction (chemistry)","score":0.5167999863624573},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.412200003862381},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.3276999890804291}],"concepts":[{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.9093999862670898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7533000111579895},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7027000188827515},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6977999806404114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6814000010490417},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.5167999863624573},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3871999979019165},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.3093999922275543},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.29760000109672546},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.25920000672340393}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe66822.2025.00119","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe66822.2025.00119","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 25th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3868211099","display_name":null,"funder_award_id":"101080905","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2031034134","https://openalex.org/W2035510150","https://openalex.org/W2060947741","https://openalex.org/W2155018999","https://openalex.org/W2168048360","https://openalex.org/W2549885908","https://openalex.org/W2748892655","https://openalex.org/W3003995118","https://openalex.org/W3047208451","https://openalex.org/W3198628337","https://openalex.org/W4324129766"],"related_works":[],"abstract_inverted_index":{"Heart":[0],"failure":[1],"(HF)":[2],"is":[3,38,64,141],"one":[4,65],"of":[5,25,32,66,109,114,118,130,170,193,227,232,253,277,284],"the":[6,12,15,67,128,214,275,278],"most":[7,68],"common":[8],"medical":[9],"conditions":[10],"around":[11],"world":[13],"in":[14,127],"modern":[16],"age.":[17],"Patients":[18],"with":[19,22,82,229],"HF":[20,41,78,115,140,149,198,216],"struggle":[21],"reduced":[23,83,119,270],"quality":[24],"life":[26],"and":[27,53,91,116,162,178,195,204,235,240,255,267,293,300],"have":[28],"a":[29,101,190],"greater":[30],"risk":[31],"death.":[33,58],"For":[34],"these":[35],"reasons":[36],"it":[37,47],"important":[39,69],"for":[40,57,106,213,237,257,297],"to":[42,49,75,112],"be":[43,73],"diagnosed":[44],"early":[45],"before":[46],"starts":[48],"majorly":[50],"impact":[51],"patients":[52,79,81,110,136,150,171],"cause":[54],"major":[55],"concern":[56],"Left":[59],"ventricular":[60],"ejection":[61,84,88,93,120,157,271],"fraction":[62,85,89,94,158,272],"(LVEF)":[63],"features":[70],"which":[71],"can":[72],"used":[74],"further":[76],"classify":[77,135],"into":[80,151,159,172],"(HFrEF),":[86],"mid-range":[87,161,268],"(HFmrEF)":[90],"preserved":[92,163],"(HFpEF).":[95],"In":[96,274],"this":[97],"paper":[98],"we":[99],"describe":[100],"machine":[102],"learning":[103],"based":[104,137,154,184],"pipeline":[105,147,167],"multistage":[107],"classification":[108,169,192,199,220,247,280],"according":[111],"presence":[113],"degree":[117],"fraction.":[121],"Two":[122],"separate":[123],"pipelines":[124,134],"are":[125],"created":[126],"scope":[129],"our":[131],"research.":[132],"Both":[133],"on":[138,155,185],"whether":[139],"present":[142],"or":[143],"not.":[144],"The":[145,165,218,243],"first":[146],"classifies":[148],"3":[152],"classes":[153],"their":[156],"reduced,":[160],"classes.":[164,197],"second":[166,191],"conducts":[168],"LVEF":[173,179,258,263],"<tex":[174,180,205,259,264,285],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[175,181,206,260,265,286],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$&lt;50":[176],"{\\%}$</tex>":[177,183],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$&gt;50":[182],"available":[186],"features,":[187],"followed":[188],"by":[189],"HFrEF":[194,241,301],"HFpEF":[196],"model":[200,221,248,281],"achieved":[201,222,249,296],"97%":[202,294],"accuracy":[203,226,252],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathbf{9":[207,287],"8":[208],"\\%}":[209],"\\mathbf{F":[210],"1}$</tex>":[211],"score":[212],"confirmed":[215],"class.":[217],"3-class":[219],"an":[223,250],"overall":[224,251],"prediction":[225],"82%":[228],"F1":[230,282],"scores":[231,283],"90%,":[233],"51%":[234],"86%":[236],"HFpEF,":[238,298],"HFmrEF":[239,299],"respectively.":[242,273,302],"final":[244],"two":[245],"stage":[246],"96%":[254],"87%":[256],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$&gt;50$</tex>%":[261],"versus":[262,269],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$&lt;50$</tex>%":[266],"case":[276],"twostage":[279],"2":[288],"\\%,":[289],"9":[290],"5":[291],"\\%}$</tex>":[292],"were":[295]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-12-11T00:00:00"}