{"id":"https://openalex.org/W4417250787","doi":"https://doi.org/10.1109/bibe66822.2025.00011","title":"Functional Enrichment of Lipidomics Data to Characterize the Metabolism of Diabetes Mellitus and Subclinical Carotid Atherosclerosis","display_name":"Functional Enrichment of Lipidomics Data to Characterize the Metabolism of Diabetes Mellitus and Subclinical Carotid Atherosclerosis","publication_year":2025,"publication_date":"2025-11-06","ids":{"openalex":"https://openalex.org/W4417250787","doi":"https://doi.org/10.1109/bibe66822.2025.00011"},"language":null,"primary_location":{"id":"doi:10.1109/bibe66822.2025.00011","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe66822.2025.00011","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 25th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088982428","display_name":"Mar\u00eda Barranco-Altirriba","orcid":"https://orcid.org/0000-0002-1525-210X"},"institutions":[{"id":"https://openalex.org/I4210092024","display_name":"Institut d'Estudis Espacials de Catalunya","ror":"https://ror.org/00k6njn28","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092024","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Maria Barranco-Altirriba","raw_affiliation_strings":["Institut de Recerca i Innovaci&#x00F3; en Salut (IRIS), Universitat Polit&#x00E8;cnica de Catalunya,B2SLab,Barcelona,Spain"],"raw_orcid":"https://orcid.org/0000-0002-1525-210X","affiliations":[{"raw_affiliation_string":"Institut de Recerca i Innovaci&#x00F3; en Salut (IRIS), Universitat Polit&#x00E8;cnica de Catalunya,B2SLab,Barcelona,Spain","institution_ids":["https://openalex.org/I4210092024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112916901","display_name":"Josch K. Pauling","orcid":null},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josch K. Pauling","raw_affiliation_strings":["Institute for Clinical Chemistry and Laboratory Medicine, Dresden University of Technology,CioBio,Dresden,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Clinical Chemistry and Laboratory Medicine, Dresden University of Technology,CioBio,Dresden,Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012291664","display_name":"D\u0131\u0301dac Mauricio","orcid":"https://orcid.org/0000-0002-2868-0250"},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Didac Mauricio","raw_affiliation_strings":["Hospital de la Santa Creu i Sant Pau,Department of Endocrinology and Nutrition,Barcelona,Spain"],"raw_orcid":"https://orcid.org/0000-0002-2868-0250","affiliations":[{"raw_affiliation_string":"Hospital de la Santa Creu i Sant Pau,Department of Endocrinology and Nutrition,Barcelona,Spain","institution_ids":["https://openalex.org/I2801795740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041616492","display_name":"Alexandre Perera-Lluna","orcid":"https://orcid.org/0000-0001-6427-851X"},"institutions":[{"id":"https://openalex.org/I4210092024","display_name":"Institut d'Estudis Espacials de Catalunya","ror":"https://ror.org/00k6njn28","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092024","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alexandre Perera-Lluna","raw_affiliation_strings":["Institut de Recerca i Innovaci&#x00F3; en Salut (IRIS), Universitat Polit&#x00E8;cnica de Catalunya,B2SLab,Barcelona,Spain"],"raw_orcid":"https://orcid.org/0000-0001-6427-851X","affiliations":[{"raw_affiliation_string":"Institut de Recerca i Innovaci&#x00F3; en Salut (IRIS), Universitat Polit&#x00E8;cnica de Catalunya,B2SLab,Barcelona,Spain","institution_ids":["https://openalex.org/I4210092024"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088982428"],"corresponding_institution_ids":["https://openalex.org/I4210092024"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34109648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"14","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5807999968528748,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5807999968528748,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipidomics","display_name":"Lipidomics","score":0.8051999807357788},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"Lipid metabolism","score":0.5090000033378601},{"id":"https://openalex.org/keywords/subclinical-infection","display_name":"Subclinical infection","score":0.4738999903202057},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.40529999136924744},{"id":"https://openalex.org/keywords/type-2-diabetes-mellitus","display_name":"Type 2 Diabetes Mellitus","score":0.36739999055862427},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.3610000014305115},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.8051999807357788},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5866000056266785},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.5090000033378601},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.4738999903202057},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.44760000705718994},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.40529999136924744},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.36739999055862427},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34850001335144043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34700000286102295},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34540000557899475},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.31299999356269836},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C86153913","wikidata":"https://www.wikidata.org/wiki/Q7682439","display_name":"Tandem mass tag","level":5,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/bibe66822.2025.00011","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe66822.2025.00011","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 25th International Conference on Bioinformatics and Bioengineering (BIBE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1975783279","https://openalex.org/W2017927472","https://openalex.org/W2096769282","https://openalex.org/W2099308584","https://openalex.org/W2108723491","https://openalex.org/W2127031535","https://openalex.org/W2486975460","https://openalex.org/W2522015218","https://openalex.org/W2605226021","https://openalex.org/W2906622050","https://openalex.org/W2949923941","https://openalex.org/W2969718750","https://openalex.org/W3036931110","https://openalex.org/W3106929620","https://openalex.org/W3116650307","https://openalex.org/W3118794296","https://openalex.org/W3118997615","https://openalex.org/W4282934107","https://openalex.org/W4294216483","https://openalex.org/W4313405588","https://openalex.org/W4387764752","https://openalex.org/W4393319497","https://openalex.org/W4411398545"],"related_works":[],"abstract_inverted_index":{"Pathway":[0],"enrichment":[1,51,75,138],"analysis":[2],"aims":[3],"to":[4,17,105,115,151],"uncover":[5],"global":[6],"functional":[7,50,74],"patterns":[8],"in":[9,24,36,108,131],"omics":[10],"data,":[11],"including":[12],"metabolomics.":[13],"However,":[14],"its":[15],"application":[16],"lipidomics,":[18],"the":[19,30,144,149],"comprehensive":[20],"study":[21],"of":[22,33,52,86],"lipids":[23,107],"biological":[25],"systems,":[26],"is":[27],"hindered":[28],"by":[29,93],"limited":[31],"availability":[32],"lipid-specific":[34],"pathways":[35],"current":[37],"databases.":[38],"Tools":[39],"such":[40],"as":[41,125,127],"LINEX<sup":[42,140],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[43,141],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[44,142],"and":[45,121,147],"LION/web":[46],"offer":[47],"solutions":[48],"for":[49],"lipids.":[53],"Nevertheless,":[54],"more":[55],"information":[56],"can":[57],"still":[58],"be":[59],"extracted":[60],"from":[61],"large":[62],"databases":[63],"like":[64],"LIPID":[65,109],"MAPS.":[66,110],"In":[67],"this":[68,113],"work,":[69],"we":[70,136],"present":[71],"a":[72,79,95],"novel":[73],"algorithm":[76,114],"based":[77],"on":[78,143],"hierarchical":[80],"graph":[81],"constructed":[82],"through":[83],"unsupervised":[84],"clustering":[85],"molecular":[87],"embeddings.":[88],"These":[89],"embeddings":[90],"were":[91],"generated":[92],"applying":[94],"SMILES":[96],"(Simplified":[97],"Molecular":[98],"Input":[99],"Line":[100],"Entry":[101],"System)":[102],"language":[103],"model":[104],"all":[106],"We":[111],"apply":[112],"five":[116],"comparisons":[117],"involving":[118],"type":[119,122,132],"1":[120],"2":[123,133],"diabetes,":[124],"well":[126],"subclinical":[128],"carotid":[129],"atherosclerosis":[130],"diabetes.":[134],"Additionally,":[135],"perform":[137],"using":[139],"same":[145],"datasets":[146],"compare":[148],"outcomes":[150],"highlight":[152],"complementary":[153],"insights.":[154]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-12-11T00:00:00"}