{"id":"https://openalex.org/W2029034032","doi":"https://doi.org/10.1109/bibe.2012.6399762","title":"Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies","display_name":"Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2029034032","doi":"https://doi.org/10.1109/bibe.2012.6399762","mag":"2029034032"},"language":"en","primary_location":{"id":"doi:10.1109/bibe.2012.6399762","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399762","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics &amp; Bioengineering (BIBE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://oa.upm.es/19500/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012580223","display_name":"Anca Bucur","orcid":"https://orcid.org/0000-0002-1940-5652"},"institutions":[{"id":"https://openalex.org/I1329325741","display_name":"Philips (Finland)","ror":"https://ror.org/01g4jev56","country_code":"FI","type":"company","lineage":["https://openalex.org/I1329325741","https://openalex.org/I4210122849"]},{"id":"https://openalex.org/I4210122849","display_name":"Philips (Netherlands)","ror":"https://ror.org/02p2bgp27","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210122849"]}],"countries":["FI","NL"],"is_corresponding":true,"raw_author_name":"Anca Bucur","raw_affiliation_strings":["Healthcare Information Management, Philips Research Europe, The Netherlands","Healthcare Information Management, Philips Research Europe, High Tech Campus 34, Eindhoven, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Healthcare Information Management, Philips Research Europe, The Netherlands","institution_ids":["https://openalex.org/I4210122849"]},{"raw_affiliation_string":"Healthcare Information Management, Philips Research Europe, High Tech Campus 34, Eindhoven, the Netherlands","institution_ids":["https://openalex.org/I1329325741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103732193","display_name":"Jasper van Leeuwen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210122849","display_name":"Philips (Netherlands)","ror":"https://ror.org/02p2bgp27","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210122849"]},{"id":"https://openalex.org/I1329325741","display_name":"Philips (Finland)","ror":"https://ror.org/01g4jev56","country_code":"FI","type":"company","lineage":["https://openalex.org/I1329325741","https://openalex.org/I4210122849"]}],"countries":["FI","NL"],"is_corresponding":false,"raw_author_name":"Jasper van Leeuwen","raw_affiliation_strings":["Healthcare Information Management, Philips Research Europe, The Netherlands","Healthcare Information Management, Philips Research Europe, High Tech Campus 34, Eindhoven, the Netherlands"],"affiliations":[{"raw_affiliation_string":"Healthcare Information Management, Philips Research Europe, The Netherlands","institution_ids":["https://openalex.org/I4210122849"]},{"raw_affiliation_string":"Healthcare Information Management, Philips Research Europe, High Tech Campus 34, Eindhoven, the Netherlands","institution_ids":["https://openalex.org/I1329325741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080728990","display_name":"David P\u00e9rez-Rey","orcid":"https://orcid.org/0000-0002-9021-2597"},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Perez-Rey","raw_affiliation_strings":["Grupo de Inform\u00e1tica Biom\u00e9dica Dept Inteligencia Artificial, Universidad Polit\u00e9cnica de Madrid, Madrid, Boadilla del Monte, Spain","Grupo de Inform\u00e1tica Biom\u00e9dica, Dept. Inteligencia Artificial, Facultad de Inform\u00e1tica, Universidad Polit\u00e9cnica de Madrid, Boadilla del Monte, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Grupo de Inform\u00e1tica Biom\u00e9dica Dept Inteligencia Artificial, Universidad Polit\u00e9cnica de Madrid, Madrid, Boadilla del Monte, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"Grupo de Inform\u00e1tica Biom\u00e9dica, Dept. Inteligencia Artificial, Facultad de Inform\u00e1tica, Universidad Polit\u00e9cnica de Madrid, Boadilla del Monte, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020992408","display_name":"Raul Alonso Calvo","orcid":null},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raul Alonso Calvo","raw_affiliation_strings":["Grupo de Inform\u00e1tica Biom\u00e9dica Dept Inteligencia Artificial, Universidad Polit\u00e9cnica de Madrid, Madrid, Boadilla del Monte, Spain","Grupo de Inform\u00e1tica Biom\u00e9dica, Dept. Inteligencia Artificial, Facultad de Inform\u00e1tica, Universidad Polit\u00e9cnica de Madrid, Boadilla del Monte, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Grupo de Inform\u00e1tica Biom\u00e9dica Dept Inteligencia Artificial, Universidad Polit\u00e9cnica de Madrid, Madrid, Boadilla del Monte, Spain","institution_ids":["https://openalex.org/I88060688"]},{"raw_affiliation_string":"Grupo de Inform\u00e1tica Biom\u00e9dica, Dept. Inteligencia Artificial, Facultad de Inform\u00e1tica, Universidad Polit\u00e9cnica de Madrid, Boadilla del Monte, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001974963","display_name":"Brecht Claerhout","orcid":"https://orcid.org/0000-0002-7366-9202"},"institutions":[{"id":"https://openalex.org/I4210092488","display_name":"Custodix (Belgium)","ror":"https://ror.org/00m6eb133","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210092488"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Brecht Claerhout","raw_affiliation_strings":["Custodix NV Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium","Custodix NV, Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium"],"affiliations":[{"raw_affiliation_string":"Custodix NV Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium","institution_ids":["https://openalex.org/I4210092488"]},{"raw_affiliation_string":"Custodix NV, Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium","institution_ids":["https://openalex.org/I4210092488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059710354","display_name":"Kristof de Schepper","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092488","display_name":"Custodix (Belgium)","ror":"https://ror.org/00m6eb133","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210092488"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kristof de Schepper","raw_affiliation_strings":["Custodix NV Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium","Custodix NV, Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium"],"affiliations":[{"raw_affiliation_string":"Custodix NV Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium","institution_ids":["https://openalex.org/I4210092488"]},{"raw_affiliation_string":"Custodix NV, Kortrijksesteenweg 214b3, Sint-Martens-Latem, Belgium","institution_ids":["https://openalex.org/I4210092488"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5012580223"],"corresponding_institution_ids":["https://openalex.org/I1329325741","https://openalex.org/I4210122849"],"apc_list":null,"apc_paid":null,"fwci":0.5253,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64320715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"413","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9847000241279602,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9753000140190125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snomed-ct","display_name":"SNOMED CT","score":0.829407811164856},{"id":"https://openalex.org/keywords/semantics","display_name":"Semantics (computer science)","score":0.6833878755569458},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6753994226455688},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.6506913900375366},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.504002034664154},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.49073660373687744},{"id":"https://openalex.org/keywords/systematized-nomenclature-of-medicine","display_name":"Systematized Nomenclature of Medicine","score":0.4741456210613251},{"id":"https://openalex.org/keywords/terminology","display_name":"Terminology","score":0.4440455734729767},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41845273971557617},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.4084276854991913},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24013331532478333},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.12130004167556763},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09764695167541504},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09258243441581726}],"concepts":[{"id":"https://openalex.org/C206497026","wikidata":"https://www.wikidata.org/wiki/Q1753883","display_name":"SNOMED CT","level":3,"score":0.829407811164856},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.6833878755569458},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6753994226455688},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.6506913900375366},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.504002034664154},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.49073660373687744},{"id":"https://openalex.org/C44681071","wikidata":"https://www.wikidata.org/wiki/Q4048820","display_name":"Systematized Nomenclature of Medicine","level":4,"score":0.4741456210613251},{"id":"https://openalex.org/C547195049","wikidata":"https://www.wikidata.org/wiki/Q1725664","display_name":"Terminology","level":2,"score":0.4440455734729767},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41845273971557617},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.4084276854991913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24013331532478333},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.12130004167556763},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09764695167541504},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09258243441581726},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/bibe.2012.6399762","is_oa":false,"landing_page_url":"https://doi.org/10.1109/bibe.2012.6399762","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 IEEE 12th International Conference on Bioinformatics &amp; Bioengineering (BIBE)","raw_type":"proceedings-article"},{"id":"pmh:oai:oa.upm.es:19500","is_oa":true,"landing_page_url":"https://oa.upm.es/19500/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196323","display_name":"UPM Digital Archive (Technical University of Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I88060688","host_organization_name":"Universidad Polit\u00e9cnica de Madrid","host_organization_lineage":["https://openalex.org/I88060688"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics &amp; Bioengineering (BIBE), 2012 IEEE 12th International Conference on | Proceedings of a meeting held 11-13 November 2012 | 11/11/2012 - 13/11/2012 | Larnaca, Cyprus","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:oa.upm.es:19500","is_oa":true,"landing_page_url":"https://oa.upm.es/19500/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196323","display_name":"UPM Digital Archive (Technical University of Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I88060688","host_organization_name":"Universidad Polit\u00e9cnica de Madrid","host_organization_lineage":["https://openalex.org/I88060688"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics &amp; Bioengineering (BIBE), 2012 IEEE 12th International Conference on | Proceedings of a meeting held 11-13 November 2012 | 11/11/2012 - 13/11/2012 | Larnaca, Cyprus","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"score":0.46000000834465027,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320338370","display_name":"FP7 Information and Communication Technologies","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W12418269","https://openalex.org/W1498129555","https://openalex.org/W2007577091","https://openalex.org/W2066578320","https://openalex.org/W2397450336"],"related_works":["https://openalex.org/W2581432157","https://openalex.org/W983237315","https://openalex.org/W4386159309","https://openalex.org/W4295077997","https://openalex.org/W4384914659","https://openalex.org/W2419080317","https://openalex.org/W328302119","https://openalex.org/W1708042184","https://openalex.org/W1511848092","https://openalex.org/W2405923535"],"abstract_inverted_index":{"An":[0],"important":[1],"objective":[2],"of":[3,19,32,35,54,71,74,84,87,115,118,140,148,152,168,175,193,218],"the":[4,16,29,33,66,69,72,81,85,88,97,104,116,119,130,146,149,165,169,172,191,199,206],"INTEGRATE":[5],"project":[6],"<sup":[7],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[8],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">1</sup>":[9],"is":[10,49,179],"to":[11,43,93,186,198,209,213,224],"build":[12],"tools":[13],"that":[14,58,144,222],"support":[15],"efficient":[17],"execution":[18],"post-genomic":[20],"multi-centric":[21],"clinical":[22,120,131,156],"trials":[23,153],"in":[24,46,91,103,129,154,171,184,216],"breast":[25,176],"cancer,":[26],"which":[27],"includes":[28],"automatic":[30],"assessment":[31,70],"eligibility":[34,56,73,89,122,150],"patients":[36],"for":[37,77,101,190],"available":[38,100],"trials.":[39],"The":[40],"population":[41],"suited":[42],"be":[44,225],"enrolled":[45],"a":[47,52,75,78],"trial":[48,79,121],"described":[50],"by":[51],"set":[53],"free-text":[55],"criteria":[57,90,123,151],"are":[59],"both":[60],"syntactically":[61],"and":[62,158],"semantically":[63],"complex.":[64],"At":[65],"same":[67],"time,":[68],"patient":[76,98,201],"requires":[80],"(machine-processable)":[82],"understanding":[83],"semantics":[86,117,147],"order":[92,185],"further":[94,204],"evaluate":[95,164],"if":[96],"data":[99],"example":[102],"hospital":[105],"EHR":[106],"satisfies":[107],"these":[108,141,160,195],"criteria.":[109],"This":[110],"paper":[111],"presents":[112],"an":[113],"analysis":[114],"based":[124],"on":[125],"relevant":[126],"medical":[127],"ontologies":[128,143],"research":[132],"domain:":[133],"SNOMED-CT,":[134],"LOINC,":[135],"MedDRA.":[136],"We":[137,203],"detect":[138],"subsets":[139],"widely-adopted":[142],"characterize":[145],"various":[155],"domains":[157,215],"compare":[159],"sets.":[161],"Next,":[162],"we":[163],"occurrence":[166],"frequency":[167],"concepts":[170,197],"concrete":[173],"case":[174],"cancer":[177],"(which":[178],"our":[180,211],"first":[181],"application":[182],"domain)":[183],"provide":[187],"meaningful":[188],"priorities":[189],"task":[192],"binding/mapping":[194],"ontology":[196],"actual":[200],"data.":[202],"assess":[205],"effort":[207],"required":[208],"extend":[210],"approach":[212],"new":[214],"terms":[217],"additional":[219],"semantic":[220],"mappings":[221],"need":[223],"developed.":[226]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}