{"id":"https://openalex.org/W3152031747","doi":"https://doi.org/10.1109/wsc48552.2020.9384086","title":"Performance and Soundness of Simulation: A Case Study Based on a Cellular Automaton for In-Body Spread of HIV","display_name":"Performance and Soundness of Simulation: A Case Study Based on a Cellular Automaton for In-Body Spread of HIV","publication_year":2020,"publication_date":"2020-12-14","ids":{"openalex":"https://openalex.org/W3152031747","doi":"https://doi.org/10.1109/wsc48552.2020.9384086","mag":"3152031747"},"language":"en","primary_location":{"id":"doi:10.1109/wsc48552.2020.9384086","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc48552.2020.9384086","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 Winter Simulation Conference (WSC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029430276","display_name":"Till K\u00f6ster","orcid":"https://orcid.org/0000-0003-0869-381X"},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Till Koster","raw_affiliation_strings":["University of Rostock, Germany"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023496425","display_name":"Philippe J. Giabbanelli","orcid":"https://orcid.org/0000-0001-6816-355X"},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philippe J. Giabbanelli","raw_affiliation_strings":["Miami University, Oxford, OH, USA"],"affiliations":[{"raw_affiliation_string":"Miami University, Oxford, OH, USA","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063515034","display_name":"Adelinde M. Uhrmacher","orcid":"https://orcid.org/0000-0001-5256-4682"},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adelinde Uhrmacher","raw_affiliation_strings":["University of Rostock, Germany"],"affiliations":[{"raw_affiliation_string":"University of Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029430276"],"corresponding_institution_ids":["https://openalex.org/I4665924"],"apc_list":null,"apc_paid":null,"fwci":1.1921,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79076362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"2281","last_page":"2292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soundness","display_name":"Soundness","score":0.9726805686950684},{"id":"https://openalex.org/keywords/cellular-automaton","display_name":"Cellular automaton","score":0.7755005359649658},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6829124689102173},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.6007347106933594},{"id":"https://openalex.org/keywords/automaton","display_name":"Automaton","score":0.5211398601531982},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4543752372264862},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3137718439102173},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.17044192552566528},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16517606377601624},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.15444111824035645}],"concepts":[{"id":"https://openalex.org/C39920170","wikidata":"https://www.wikidata.org/wiki/Q693083","display_name":"Soundness","level":2,"score":0.9726805686950684},{"id":"https://openalex.org/C35527583","wikidata":"https://www.wikidata.org/wiki/Q189156","display_name":"Cellular automaton","level":2,"score":0.7755005359649658},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6829124689102173},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6007347106933594},{"id":"https://openalex.org/C112505250","wikidata":"https://www.wikidata.org/wiki/Q787116","display_name":"Automaton","level":2,"score":0.5211398601531982},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4543752372264862},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3137718439102173},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.17044192552566528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16517606377601624},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.15444111824035645}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/wsc48552.2020.9384086","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc48552.2020.9384086","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 Winter Simulation Conference (WSC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W10363999","https://openalex.org/W50795042","https://openalex.org/W1972501464","https://openalex.org/W1973016141","https://openalex.org/W1992520358","https://openalex.org/W1992870153","https://openalex.org/W2001917666","https://openalex.org/W2006219063","https://openalex.org/W2009649053","https://openalex.org/W2022756003","https://openalex.org/W2023734936","https://openalex.org/W2051525127","https://openalex.org/W2057975334","https://openalex.org/W2058120380","https://openalex.org/W2077883597","https://openalex.org/W2118036437","https://openalex.org/W2124988726","https://openalex.org/W2127832030","https://openalex.org/W2263695121","https://openalex.org/W2276662578","https://openalex.org/W2596103771","https://openalex.org/W2806043078","https://openalex.org/W2887383860","https://openalex.org/W2911948847","https://openalex.org/W2947682047","https://openalex.org/W3034073466","https://openalex.org/W3090938217","https://openalex.org/W3191256471","https://openalex.org/W4245562072","https://openalex.org/W4298314108","https://openalex.org/W6602055124","https://openalex.org/W6752931098","https://openalex.org/W6784080563"],"related_works":["https://openalex.org/W1511249877","https://openalex.org/W2466303427","https://openalex.org/W1578828174","https://openalex.org/W2000943029","https://openalex.org/W2293004035","https://openalex.org/W18781025","https://openalex.org/W188034648","https://openalex.org/W2952519015","https://openalex.org/W2155728227","https://openalex.org/W2141069492"],"abstract_inverted_index":{"Cellular":[0],"automata":[1,44],"are":[2,46,81,180],"often":[3],"used":[4],"for":[5,69],"spatial":[6],"dynamics":[7],"in":[8,28,78,139,150],"cell":[9,19],"biology":[10],"such":[11,106],"as":[12,64],"the":[13,24,39,56,65,70,151,162,169],"spread":[14],"of":[15,26,58,137,185],"infections":[16],"within":[17],"a":[18,29,59,88,130,135,142],"biological":[20],"population.":[21],"Due":[22],"to":[23,98,113,141,161,168,182],"number":[25],"cells":[27],"model,":[30],"efficient":[31,101],"simulation":[32,102,155],"algorithms":[33],"have":[34],"received":[35],"increasing":[36],"attention":[37],"over":[38],"last":[40],"decade.":[41],"Many":[42],"cellular":[43,60],"models":[45,173],"executed":[47],"synchronously.":[48],"In":[49],"this":[50,79],"paper,":[51],"we":[52],"focus":[53],"on":[54],"improving":[55],"efficiency":[57],"automaton":[61],"model":[62,68,80,152],"known":[63],"`dos":[66],"Santos'":[67],"Human":[71],"Immunodeficiency":[72],"Virus":[73],"(HIV).":[74],"The":[75,127],"synchronous":[76,171],"updates":[77],"driven":[82],"by":[83,134],"mostly":[84],"deterministic":[85],"transitions":[86],"and":[87,154],"few":[89],"highly":[90],"probabilistic":[91,120],"transitions.":[92],"This":[93],"design":[94,165],"can":[95],"be":[96],"exploited":[97],"create":[99],"an":[100,107,110],"algorithm.":[103],"We":[104,146],"propose":[105],"algorithm":[108],"using":[109],"advanced":[111],"scheme":[112],"generate":[114],"random":[115],"numbers":[116],"(to":[117],"efficiently":[118,123],"perform":[119],"transitions)":[121],"that":[122],"leverages":[124],"CPU":[125],"vectorization.":[126],"benchmarks":[128],"show":[129],"significant":[131],"performance":[132],"increase":[133],"factor":[136],"2.4x":[138],"comparison":[140],"quality":[143],"baseline":[144],"implementation.":[145],"note":[147],"several":[148],"limitations":[149],"behavior":[153],"outputs,":[156],"which":[157],"apply":[158],"not":[159],"only":[160],"dos":[163],"Santos":[164],"but":[166],"also":[167],"many":[170],"HIV":[172],"inheriting":[174],"its":[175],"design.":[176],"Several":[177],"mitigation":[178],"schemes":[179],"discussed":[181],"address":[183],"some":[184],"these":[186],"limitations.":[187]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
