{"id":"https://openalex.org/W2782617869","doi":"https://doi.org/10.1109/wsc.2017.8248206","title":"Exploiting equation-free analysis for multi-level, agent-based models in cell biology","display_name":"Exploiting equation-free analysis for multi-level, agent-based models in cell biology","publication_year":2017,"publication_date":"2017-12-01","ids":{"openalex":"https://openalex.org/W2782617869","doi":"https://doi.org/10.1109/wsc.2017.8248206","mag":"2782617869"},"language":"en","primary_location":{"id":"doi:10.1109/wsc.2017.8248206","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc.2017.8248206","pdf_url":null,"source":{"id":"https://openalex.org/S4363607803","display_name":"2017 Winter Simulation Conference (WSC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 Winter Simulation Conference (WSC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002063485","display_name":"Kai Budde","orcid":"https://orcid.org/0000-0001-6836-9865"},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Kai Budde","raw_affiliation_strings":["University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061972689","display_name":"Tom Warnke","orcid":"https://orcid.org/0000-0002-8196-2943"},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tom Warnke","raw_affiliation_strings":["University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063515034","display_name":"Adelinde M. Uhrmacher","orcid":"https://orcid.org/0000-0001-5256-4682"},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Adelinde M. Uhrmacher","raw_affiliation_strings":["University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083987906","display_name":"Eric Schatz","orcid":null},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Eric Schatz","raw_affiliation_strings":["University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056304562","display_name":"Jens Starke","orcid":"https://orcid.org/0000-0001-9411-5893"},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jens Starke","raw_affiliation_strings":["University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rostock Albert-Einstein-Str.22, Rostock, GERMANY","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4665924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090554724","display_name":"Fiete Haack","orcid":"https://orcid.org/0000-0003-3713-8313"},"institutions":[{"id":"https://openalex.org/I4210119682","display_name":"Research Institute for Farm Animal Biology (FBN)","ror":"https://ror.org/02n5r1g44","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210119682"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fiete Haack","raw_affiliation_strings":["Leibniz Institute for Farm Animal Biology Wilhelm-Stahl-Allee2, Dummerstorf, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz Institute for Farm Animal Biology Wilhelm-Stahl-Allee2, Dummerstorf, GERMANY","institution_ids":["https://openalex.org/I4210119682"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4564","last_page":"4565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7335692644119263},{"id":"https://openalex.org/keywords/multistability","display_name":"Multistability","score":0.7203511595726013},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.5352792143821716},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.45505577325820923},{"id":"https://openalex.org/keywords/dynamical-systems-theory","display_name":"Dynamical systems theory","score":0.43402761220932007},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.38221240043640137},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3276204466819763},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.1938820481300354},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16881704330444336}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7335692644119263},{"id":"https://openalex.org/C2776966350","wikidata":"https://www.wikidata.org/wiki/Q6935096","display_name":"Multistability","level":3,"score":0.7203511595726013},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.5352792143821716},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.45505577325820923},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.43402761220932007},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.38221240043640137},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3276204466819763},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.1938820481300354},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16881704330444336},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/wsc.2017.8248206","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc.2017.8248206","pdf_url":null,"source":{"id":"https://openalex.org/S4363607803","display_name":"2017 Winter Simulation Conference (WSC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2017 Winter Simulation Conference (WSC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1971196026","https://openalex.org/W1974143589","https://openalex.org/W2084581385","https://openalex.org/W2148717806","https://openalex.org/W2512618608","https://openalex.org/W2615981627"],"related_works":["https://openalex.org/W1527571384","https://openalex.org/W2383189914","https://openalex.org/W4301445084","https://openalex.org/W2963840034","https://openalex.org/W1984975294","https://openalex.org/W4226178663","https://openalex.org/W2076976025","https://openalex.org/W4323927134","https://openalex.org/W2043671984","https://openalex.org/W2153650232"],"abstract_inverted_index":{"Multi-level":[0],"modeling":[1,146],"approaches":[2,73,91],"have":[3],"been":[4,104],"successfully":[5],"applied":[6,105],"in":[7,112,143,152],"systems":[8,13,98],"biology":[9],"to":[10,41,60,67,106,135],"model":[11],"complex":[12,52,97],"with":[14,51,83],"different":[15],"levels":[16],"of":[17,96,119,139],"organization.":[18],"They":[19],"allow":[20,93],"for":[21,47,64,94],"straightforwardly":[22],"integrating":[23],"upward":[24],"and":[25,79,149],"downward":[26],"causation":[27],"as":[28,30],"well":[29],"compartmental":[31],"dynamics.":[32],"This":[33],"makes":[34],"multi-level":[35,53,145],"models":[36,54,78,82],"powerful,":[37],"but":[38],"also":[39],"expensive":[40],"simulate.":[42],"Consequently,":[43],"the":[44,62,89,117,124,144],"effort":[45],"required":[46],"comprehensive":[48],"simulation":[49,125],"studies":[50],"is":[55,66,99],"often":[56],"prohibitive.":[57],"One":[58],"way":[59],"decrease":[61],"demand":[63],"simulations":[65],"apply":[68],"analysis":[69,95,111],"methods.":[70],"However,":[71],"most":[72],"focus":[74],"on":[75,130],"differential":[76],"equations":[77],"cannot":[80],"handle":[81],"stochasticity":[84],"or":[85],"dynamical":[86],"nesting.":[87],"Among":[88],"new":[90],"that":[92],"equation-free":[100,121],"analysis,":[101],"which":[102],"has":[103],"perform":[107],"coarse":[108],"level":[109],"bifurcation":[110],"various":[113],"areas.":[114],"We":[115],"present":[116],"integration":[118],"an":[120],"method":[122],"into":[123],"language":[126,147],"Simulation":[127],"Experiment":[128],"Specification":[129],"a":[131],"Scala":[132],"Layer":[133],"(SESSL)":[134],"analyze":[136],"bi-or":[137],"multistability":[138],"biochemical":[140],"models,":[141],"defined":[142],"ML-Rules,":[148],"its":[150],"role":[151],"cell":[153],"fate":[154],"selection.":[155]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}