{"id":"https://openalex.org/W4230363597","doi":"https://doi.org/10.1109/wsc.2015.7408269","title":"Stochastic approximation for regulating circadian cycles, a precision medicine viewpoint","display_name":"Stochastic approximation for regulating circadian cycles, a precision medicine viewpoint","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W4230363597","doi":"https://doi.org/10.1109/wsc.2015.7408269"},"language":"en","primary_location":{"id":"doi:10.1109/wsc.2015.7408269","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc.2015.7408269","pdf_url":null,"source":{"id":"https://openalex.org/S4363607791","display_name":"2015 Winter Simulation Conference (WSC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Winter Simulation Conference (WSC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047511490","display_name":"Alexey Nikolaev","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexey Nikolaev","raw_affiliation_strings":["Department of Computer Science, CUNY Institute for Computer Simulation, Stochastic Modeling and Optimization, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, CUNY Institute for Computer Simulation, Stochastic Modeling and Optimization, NY, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029543403","display_name":"Felisa J. V\u00e1zquez-Abad","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felisa J. Vazquez-Abad","raw_affiliation_strings":["Department of Computer Science, CUNY Institute for Computer Simulation, Stochastic Modeling and Optimization, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, CUNY Institute for Computer Simulation, Stochastic Modeling and Optimization, NY, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1471","last_page":"1482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9628000259399414,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.527324378490448},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5098497271537781},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.45511960983276367},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17660459876060486},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.14941319823265076}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.527324378490448},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5098497271537781},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.45511960983276367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17660459876060486},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14941319823265076},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/wsc.2015.7408269","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc.2015.7408269","pdf_url":null,"source":{"id":"https://openalex.org/S4363607791","display_name":"2015 Winter Simulation Conference (WSC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 Winter Simulation Conference (WSC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.550000011920929,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2013244539","https://openalex.org/W2046451925","https://openalex.org/W2106216878","https://openalex.org/W2108493072","https://openalex.org/W2125422443","https://openalex.org/W2155418451","https://openalex.org/W2493209382","https://openalex.org/W4234468949","https://openalex.org/W6722775039"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3195765690","https://openalex.org/W2395497249","https://openalex.org/W2414585471","https://openalex.org/W3153505006","https://openalex.org/W2106786363","https://openalex.org/W4211153993","https://openalex.org/W4286276023","https://openalex.org/W3094428736"],"abstract_inverted_index":{"Circadian":[0],"cycles":[1],"and":[2,16,32,57,133],"other":[3],"self-regulatory":[4],"biological":[5],"processes":[6],"are":[7,64],"the":[8,29,47,58,69,72,91,94,113,130,137,140],"result":[9,98],"of":[10,28,43,51,60,65,71,139,148],"complex":[11],"interactions":[12],"between":[13],"gene":[14],"expression":[15],"molecular":[17],"interactions.":[18],"In":[19],"this":[20],"paper":[21],"we":[22],"study":[23],"a":[24,100,105],"Petri":[25],"net":[26],"model":[27,107,125],"circadian":[30],"clock":[31],"use":[33,87],"gradient":[34,109,115,127],"estimation":[35,110,128],"methods":[36],"for":[37,68,77,108,116,126],"finding":[38],"optimal":[39,95],"input":[40],"rates.The":[41],"significance":[42],"our":[44],"research":[45],"is":[46],"potential":[48],"early":[49],"identification":[50],"pathologies":[52],"caused":[53],"by":[54,121,143],"aberrant":[55],"cycles,":[56,73],"discovery":[59],"those":[61],"rates":[62,96],"that":[63,97,111],"main":[66],"importance":[67],"control":[70],"enabling":[74],"specific":[75],"cures":[76],"people,":[78],"in":[79,99],"accordance":[80],"with":[81],"personalized":[82],"(or":[83],"precision)":[84],"medicine.":[85],"We":[86],"SPSA":[88],"to":[89,93],"drive":[90],"simulation":[92],"desired":[101],"period,":[102],"then":[103],"propose":[104],"surrogate":[106],"evaluates":[112],"exact":[114],"an":[117],"\u201caggregate\u201d":[118],"system":[119],"described":[120],"ODEs.":[122],"Our":[123],"hybrid":[124],"addresses":[129],"high-dimensionality":[131],"problem":[132],"can":[134],"potentially":[135],"increase":[136],"efficiency":[138],"optimization":[141],"method":[142],"at":[144],"least":[145],"one":[146],"order":[147],"magnitude.":[149]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
