{"id":"https://openalex.org/W3139952980","doi":"https://doi.org/10.1109/wsc.2010.5679128","title":"Simulating plausible mechanisms for changing hepatic xenobiotic clearance patterns","display_name":"Simulating plausible mechanisms for changing hepatic xenobiotic clearance patterns","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W3139952980","doi":"https://doi.org/10.1109/wsc.2010.5679128","mag":"3139952980"},"language":"en","primary_location":{"id":"doi:10.1109/wsc.2010.5679128","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc.2010.5679128","pdf_url":null,"source":{"id":"https://openalex.org/S4363608948","display_name":"Proceedings of the 2010 Winter Simulation Conference","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2010 Winter Simulation Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051341363","display_name":"Shahab Sheikh-Bahaei","orcid":null},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shahab Sheikh-Bahaei","raw_affiliation_strings":["University of California, Berkeley, CA, USA"],"affiliations":[{"raw_affiliation_string":"University of California, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001335754","display_name":"C. Anthony Hunt","orcid":"https://orcid.org/0000-0001-9372-6860"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Anthony Hunt","raw_affiliation_strings":["Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051341363"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62193126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"310","issue":null,"first_page":"595","last_page":"607"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.6186611652374268},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5512866377830505},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.49993252754211426},{"id":"https://openalex.org/keywords/sss*","display_name":"SSS*","score":0.44202345609664917},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4367794692516327},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.42956024408340454},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4193195700645447},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28960180282592773},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.27784156799316406},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2735545039176941},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09913620352745056},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09737733006477356}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6186611652374268},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5512866377830505},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.49993252754211426},{"id":"https://openalex.org/C148699463","wikidata":"https://www.wikidata.org/wiki/Q3492668","display_name":"SSS*","level":2,"score":0.44202345609664917},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4367794692516327},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.42956024408340454},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4193195700645447},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28960180282592773},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27784156799316406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2735545039176941},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09913620352745056},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09737733006477356},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/wsc.2010.5679128","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wsc.2010.5679128","pdf_url":null,"source":{"id":"https://openalex.org/S4363608948","display_name":"Proceedings of the 2010 Winter Simulation Conference","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2010 Winter Simulation Conference","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.416.4777","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.416.4777","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.informs-sim.org/wsc10papers/054.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322864","display_name":"Isfahan University of Technology","ror":"https://ror.org/00af3sa43"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320332923","display_name":"U.S. Navy","ror":"https://ror.org/03ar0mv07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W66282781","https://openalex.org/W1932377803","https://openalex.org/W1967261220","https://openalex.org/W1973021910","https://openalex.org/W1986397618","https://openalex.org/W1987521497","https://openalex.org/W1991274852","https://openalex.org/W1992888159","https://openalex.org/W1997208865","https://openalex.org/W2000277421","https://openalex.org/W2006012747","https://openalex.org/W2008566763","https://openalex.org/W2029867647","https://openalex.org/W2037599820","https://openalex.org/W2038927157","https://openalex.org/W2056464330","https://openalex.org/W2061717797","https://openalex.org/W2074329778","https://openalex.org/W2092578710","https://openalex.org/W2125595479","https://openalex.org/W2151654304","https://openalex.org/W2154514556","https://openalex.org/W4248745245","https://openalex.org/W4251266081"],"related_works":["https://openalex.org/W4254148397","https://openalex.org/W2312544039","https://openalex.org/W2130422680","https://openalex.org/W2262308488","https://openalex.org/W2291521583","https://openalex.org/W2181393623","https://openalex.org/W3183058467","https://openalex.org/W2068666169","https://openalex.org/W2391599106","https://openalex.org/W2361521353"],"abstract_inverted_index":{"No":[0],"concrete,":[1],"causal,":[2],"mechanistic":[3],"theory":[4],"is":[5,74],"available":[6],"to":[7,35,70,94,108,132],"explain":[8],"how":[9,46],"different":[10,24],"hepatic":[11],"zonation":[12,50],"patterns":[13,51,127],"of":[14,31,76,80,102,114,126],"P450":[15],"isozyme":[16],"levels":[17],"and":[18,33,38,47,53,92,98],"hepatotoxicity":[19],"emerge":[20,52],"following":[21],"dosing":[22],"with":[23,111],"compounds.":[25,71],"We":[26,58],"used":[27],"the":[28,99,112,136],"synthetic":[29],"method":[30],"modeling":[32],"simulation":[34],"discover,":[36],"explore,":[37],"experimentally":[39],"challenge":[40],"a":[41,77,103,124],"concrete":[42],"mechanism":[43],"that":[44,60,128],"shows":[45],"why":[48],"biomimetic":[49],"change":[54],"within":[55],"agent-based":[56],"analogues.":[57],"hypothesized":[59],"those":[61,133],"mechanisms":[62],"have":[63],"counterparts":[64],"in":[65,135],"rats.":[66],"Mobile":[67],"objects":[68],"map":[69],"One":[72],"analogue":[73],"comprised":[75],"linear":[78],"sequence":[79],"20":[81],"identical,":[82],"quasi-autonomous":[83],"functional":[84],"units":[85],"called":[86],"sinusoidal":[87],"segments":[88],"(SSs).":[89],"SSs":[90],"detect":[91],"respond":[93],"compound-generated":[95],"response":[96],"signals":[97],"local":[100],"level":[101],"gradient.":[104],"Each":[105],"SS":[106],"adapts":[107],"new":[109],"information":[110],"objective":[113],"improving":[115],"efficiency":[116],"(lowering":[117],"costs).":[118],"Upon":[119],"compound":[120],"exposure,":[121],"analogues":[122],"developed":[123],"variety":[125],"were":[129],"strikingly":[130],"similar":[131],"reported":[134],"literature.":[137]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}