{"id":"https://openalex.org/W4416925074","doi":"https://doi.org/10.1109/wimob66857.2025.11257494","title":"Inferring CAF-1/p60 Expression from Hematoxylin and Eosin Stained Images in Oral Squamous Cell Carcinoma","display_name":"Inferring CAF-1/p60 Expression from Hematoxylin and Eosin Stained Images in Oral Squamous Cell Carcinoma","publication_year":2025,"publication_date":"2025-10-20","ids":{"openalex":"https://openalex.org/W4416925074","doi":"https://doi.org/10.1109/wimob66857.2025.11257494"},"language":null,"primary_location":{"id":"doi:10.1109/wimob66857.2025.11257494","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wimob66857.2025.11257494","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 21th International Conference on Wireless and Mobile Computing, Networking and Communications (WiMob)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035723769","display_name":"Cristian Tommasino","orcid":"https://orcid.org/0000-0001-9763-8745"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cristian Tommasino","raw_affiliation_strings":["University of Naples Federico II,Department of Electrical Engineering and Information Technology,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II,Department of Electrical Engineering and Information Technology,Naples,Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035167174","display_name":"Cristiano Russo","orcid":"https://orcid.org/0000-0002-8732-1733"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristiano Russo","raw_affiliation_strings":["University of Naples Federico II,Department of Electrical Engineering and Information Technology,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II,Department of Electrical Engineering and Information Technology,Naples,Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114579891","display_name":"Angela Crispino","orcid":"https://orcid.org/0009-0003-6344-7942"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]},{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Crispino","raw_affiliation_strings":["University of Naples Federico II,Pathology Unit,Department of Advanced Biomedical Sciences,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II,Pathology Unit,Department of Advanced Biomedical Sciences,Naples,Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027952276","display_name":"Stefania Staibano","orcid":"https://orcid.org/0000-0003-4993-9388"},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Staibano","raw_affiliation_strings":["University of Naples Federico II,Pathology Unit,Department of Advanced Biomedical Sciences,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II,Pathology Unit,Department of Advanced Biomedical Sciences,Naples,Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052542784","display_name":"Antonio M. Rinaldi","orcid":"https://orcid.org/0000-0001-7003-4781"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio M. Rinaldi","raw_affiliation_strings":["University of Naples Federico II,Department of Electrical Engineering and Information Technology,Naples,Italy"],"affiliations":[{"raw_affiliation_string":"University of Naples Federico II,Department of Electrical Engineering and Information Technology,Naples,Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061495027","display_name":"Francesco Merolla","orcid":"https://orcid.org/0000-0003-0711-6738"},"institutions":[{"id":"https://openalex.org/I129627893","display_name":"University of Molise","ror":"https://ror.org/04z08z627","country_code":"IT","type":"education","lineage":["https://openalex.org/I129627893"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Merolla","raw_affiliation_strings":["University of Molise,Department of Medicine and Health Sciences &#x201C;V. Tiberio&#x201D;,Campobasso,Italy"],"affiliations":[{"raw_affiliation_string":"University of Molise,Department of Medicine and Health Sciences &#x201C;V. Tiberio&#x201D;,Campobasso,Italy","institution_ids":["https://openalex.org/I129627893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035723769"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21204466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.3165000081062317,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.3165000081062317,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.24120000004768372,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.2290000021457672,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h-e-stain","display_name":"H&E stain","score":0.8675000071525574},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.7559000253677368},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.5543000102043152},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5088000297546387},{"id":"https://openalex.org/keywords/basal-cell","display_name":"Basal cell","score":0.47999998927116394},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"Digital pathology","score":0.4171999990940094},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.3529999852180481},{"id":"https://openalex.org/keywords/carcinoma","display_name":"Carcinoma","score":0.3424000144004822}],"concepts":[{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.8675000071525574},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7559000253677368},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6205999851226807},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5543000102043152},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5088000297546387},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.47999998927116394},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.4171999990940094},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3650999963283539},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36309999227523804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3546000123023987},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3529999852180481},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.33379998803138733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31790000200271606},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31690001487731934},{"id":"https://openalex.org/C194495517","wikidata":"https://www.wikidata.org/wiki/Q7646222","display_name":"Surgical pathology","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2849999964237213},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C2779751288","wikidata":"https://www.wikidata.org/wiki/Q422637","display_name":"Eosin","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C2988782748","wikidata":"https://www.wikidata.org/wiki/Q5058202","display_name":"Cell structure","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C549673821","wikidata":"https://www.wikidata.org/wiki/Q683455","display_name":"Anatomical pathology","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/wimob66857.2025.11257494","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wimob66857.2025.11257494","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 21th International Conference on Wireless and Mobile Computing, Networking and Communications (WiMob)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W629993323","https://openalex.org/W2168056522","https://openalex.org/W2194775991","https://openalex.org/W2806530968","https://openalex.org/W2948930564","https://openalex.org/W2963351448","https://openalex.org/W3021714323","https://openalex.org/W4311723520","https://openalex.org/W4317791959","https://openalex.org/W4367856046","https://openalex.org/W4380080175","https://openalex.org/W4391427364","https://openalex.org/W4392883923","https://openalex.org/W4396609393","https://openalex.org/W4401750651","https://openalex.org/W4403269392","https://openalex.org/W4404209190","https://openalex.org/W4406038585","https://openalex.org/W4411695051","https://openalex.org/W4414167601"],"related_works":[],"abstract_inverted_index":{"Hematoxylin":[0],"and":[1,16,36,103],"Eosin":[2],"(H&E)":[3],"staining":[4,146],"remains":[5],"a":[6,79],"standard":[7],"of":[8,21,66,82,119],"histopathological":[9],"diagnostics":[10],"due":[11,45],"to":[12,29,46],"its":[13,19],"efficiency,":[14],"affordability,":[15],"ubiquity.":[17],"However,":[18],"lack":[20],"molecular":[22,136],"specificity":[23],"often":[24],"necessitates":[25],"complementary":[26],"immunohistochemistry":[27],"(IHC)":[28],"detect":[30],"protein-level":[31],"biomarkers":[32],"critical":[33],"for":[34],"diagnosis":[35],"treatment":[37],"planning.":[38],"In":[39,59],"scenarios":[40],"where":[41],"IHC":[42],"is":[43],"impractical,":[44],"cost,":[47],"limited":[48],"tissue,":[49],"or":[50,150],"logistical":[51],"constraints,":[52],"computational":[53],"alternatives":[54],"may":[55,132],"provide":[56],"viable":[57],"solutions.":[58],"this":[60],"study,":[61],"we":[62,91],"investigate":[63],"the":[64,127],"feasibility":[65],"predicting":[67],"CAF-1/p60":[68],"protein":[69,120],"expression":[70],"directly":[71],"from":[72,138],"H&E-stained":[73],"slides":[74],"using":[75],"deep":[76],"learning.":[77],"Leveraging":[78],"curated":[80],"dataset":[81],"oral":[83],"squamous":[84],"cell":[85],"carcinoma":[86],"samples":[87],"with":[88],"nucleus-level":[89],"annotations,":[90],"classify":[92],"nuclei":[93],"into":[94],"three":[95],"categories:":[96],"(i)":[97],"Tumor-CAF-1/p60-positive,":[98],"(ii)":[99],"Tumor-CAF1/p":[100],"6":[101],"0-negative,":[102],"(iii)":[104],"stromal.":[105],"Our":[106],"results":[107],"demonstrate":[108],"that":[109],"Convolutional":[110],"Neural":[111],"Networks":[112],"(CNNs)":[113],"can":[114],"learn":[115],"morphological":[116],"cues":[117],"indicative":[118],"expression,":[121],"achieving":[122],"promising":[123],"classification":[124],"performance":[125],"at":[126],"single-cell":[128],"level.":[129],"This":[130],"approach":[131],"enable":[133],"more":[134],"accessible":[135],"profiling":[137],"routine":[139],"H&E":[140],"slides,":[141],"reducing":[142],"dependency":[143],"on":[144],"specialized":[145],"procedures":[147],"in":[148],"resource-constrained":[149],"time-sensitive":[151],"settings.":[152]},"counts_by_year":[],"updated_date":"2026-03-07T16:01:11.037858","created_date":"2025-12-02T00:00:00"}
