{"id":"https://openalex.org/W4248900818","doi":"https://doi.org/10.1109/visual.2005.1532828","title":"Differential Protein Expression Analysis via Liquid-Chromatography/Mass-Spectrometry Data Visualization","display_name":"Differential Protein Expression Analysis via Liquid-Chromatography/Mass-Spectrometry Data Visualization","publication_year":2006,"publication_date":"2006-10-11","ids":{"openalex":"https://openalex.org/W4248900818","doi":"https://doi.org/10.1109/visual.2005.1532828"},"language":"en","primary_location":{"id":"doi:10.1109/visual.2005.1532828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/visual.2005.1532828","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VIS 05. IEEE Visualization, 2005.","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008969033","display_name":"L. Linsen","orcid":null},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Linsen","raw_affiliation_strings":["Department of Mathematics and Computer Science, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033204089","display_name":"J. Locherbach","orcid":null},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Locherbach","raw_affiliation_strings":["Department of Mathematics and Computer Science, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072391184","display_name":"M. Bert","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Bert","raw_affiliation_strings":["DECODON GmbH, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DECODON GmbH, Greifswald, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079421746","display_name":"J. Bernhardt","orcid":null},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Bernhardt","raw_affiliation_strings":["Department of Microbiology, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036918540","display_name":"D. Becher","orcid":null},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Becher","raw_affiliation_strings":["Department of Microbiology, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Ernst Moritz Arndt University\uc2a0of Greifswald, Greifswald, Germany","institution_ids":["https://openalex.org/I36522303"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7226,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69699411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":null,"first_page":"447","last_page":"454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8130999803543091,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8130999803543091,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.7433000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6832000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.6761944890022278},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.6366357803344727},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6068668961524963},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5673173069953918},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5038823485374451},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.4577130675315857},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.45088350772857666},{"id":"https://openalex.org/keywords/liquid-chromatography\u2013mass-spectrometry","display_name":"Liquid chromatography\u2013mass spectrometry","score":0.44133228063583374},{"id":"https://openalex.org/keywords/data-visualization","display_name":"Data visualization","score":0.4216599762439728},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.41527998447418213},{"id":"https://openalex.org/keywords/bottom-up-proteomics","display_name":"Bottom-up proteomics","score":0.4100397825241089},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3729513883590698},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34830737113952637},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"Tandem mass spectrometry","score":0.31798505783081055},{"id":"https://openalex.org/keywords/protein-mass-spectrometry","display_name":"Protein mass spectrometry","score":0.246641606092453},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1642686128616333},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10523763298988342}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6761944890022278},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.6366357803344727},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6068668961524963},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5673173069953918},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5038823485374451},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4577130675315857},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.45088350772857666},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.44133228063583374},{"id":"https://openalex.org/C172367668","wikidata":"https://www.wikidata.org/wiki/Q6504956","display_name":"Data visualization","level":3,"score":0.4216599762439728},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41527998447418213},{"id":"https://openalex.org/C112979427","wikidata":"https://www.wikidata.org/wiki/Q4949102","display_name":"Bottom-up proteomics","level":5,"score":0.4100397825241089},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3729513883590698},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34830737113952637},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.31798505783081055},{"id":"https://openalex.org/C202157981","wikidata":"https://www.wikidata.org/wiki/Q7251488","display_name":"Protein mass spectrometry","level":4,"score":0.246641606092453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1642686128616333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10523763298988342},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/visual.2005.1532828","is_oa":false,"landing_page_url":"https://doi.org/10.1109/visual.2005.1532828","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"VIS 05. IEEE Visualization, 2005.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W43444990","https://openalex.org/W1224141651","https://openalex.org/W1494985239","https://openalex.org/W1597678601","https://openalex.org/W1965942536","https://openalex.org/W1974830441","https://openalex.org/W1979853788","https://openalex.org/W1981593008","https://openalex.org/W1988676603","https://openalex.org/W1991165514","https://openalex.org/W2013943606","https://openalex.org/W2053697292","https://openalex.org/W2056099004","https://openalex.org/W2057097993","https://openalex.org/W2072969249","https://openalex.org/W2073292063","https://openalex.org/W2086470186","https://openalex.org/W2111167426","https://openalex.org/W2124650897","https://openalex.org/W2134014314","https://openalex.org/W3143378319","https://openalex.org/W6601767909","https://openalex.org/W6627972250","https://openalex.org/W6629641784"],"related_works":["https://openalex.org/W4224255595","https://openalex.org/W2522695236","https://openalex.org/W1998917212","https://openalex.org/W1968441093","https://openalex.org/W2073428151","https://openalex.org/W772488069","https://openalex.org/W2041461813","https://openalex.org/W1968381290","https://openalex.org/W1985701257","https://openalex.org/W4323347615"],"abstract_inverted_index":{"Differential":[0],"protein":[1,62,97,184],"expression":[2,156],"analysis":[3,101,148],"is":[4,35,64,103],"one":[5],"of":[6,52,80,115,127,139,149,151],"the":[7,14,38,49,53,71,78,81,125,137,140,158],"main":[8],"challenges":[9],"in":[10,32,48,111,130,142,165],"proteomics.":[11],"It":[12],"denotes":[13],"search":[15],"for":[16,61,108,124,136],"proteins,":[17],"whose":[18],"encoding":[19],"genes":[20],"are":[21],"differentially":[22,39],"expressed":[23,40],"under":[24],"a":[25,112,131,146,192],"given":[26],"experimental":[27],"setup.":[28],"An":[29],"important":[30],"task":[31],"this":[33],"context":[34],"to":[36,65,91,201],"identify":[37],"proteins":[41,46,67],"or,":[42],"more":[43],"generally,":[44],"all":[45],"present":[47,119],"sample.":[50],"One":[51],"most":[54],"promising":[55],"and":[56,76,94,145,161,196],"recently":[57],"widely":[58],"used":[59],"approaches":[60],"identification":[63,185],"cleave":[66],"into":[68],"peptides,":[69],"separate":[70],"peptides":[72,83],"using":[73,84,182],"liquid":[74],"chromatography,":[75],"determine":[77],"masses":[79],"separated":[82],"mass":[85],"spectrometry.":[86],"The":[87,100],"resulting":[88],"data":[89,129,141,175,180,194],"needs":[90],"be":[92],"analyzed":[93],"matched":[95],"against":[96],"sequence":[98],"databases.":[99],"step":[102],"typically":[104],"done":[105],"by":[106],"searching":[107],"intensity":[109],"peaks":[110],"large":[113],"number":[114],"2D":[116],"graphs.":[117],"We":[118,153],"an":[120],"interactive":[121],"visualization":[122],"tool":[123,170],"exploration":[126,169],"liquid-chromatography/mass-spectrometry":[128,159,174],"3D":[132],"space,":[133],"which":[134],"allows":[135],"understanding":[138],"its":[143],"entirety":[144],"detailed":[147],"regions":[150],"interest.":[152],"compute":[154],"differential":[155],"over":[157],"domain":[160],"embed":[162],"it":[163],"visually":[164],"our":[166],"system.":[167],"Our":[168],"can":[171],"treat":[172],"single":[173],"sets":[176],"as":[177,179],"well":[178],"acquired":[181],"multi-dimensional":[183],"technology.":[186],"For":[187],"efficiency":[188],"purposes":[189],"we":[190],"perform":[191],"peak-preserving":[193],"resampling":[195],"multiresolution":[197],"hierarchy":[198],"generation":[199],"prior":[200],"visualization.":[202]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}