{"id":"https://openalex.org/W2150837293","doi":"https://doi.org/10.1109/vecims.2009.5068878","title":"Real time measurement of cellular Oxygen Uptake Rates (OUR) by a fiber optic sensor","display_name":"Real time measurement of cellular Oxygen Uptake Rates (OUR) by a fiber optic sensor","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2150837293","doi":"https://doi.org/10.1109/vecims.2009.5068878","mag":"2150837293"},"language":"en","primary_location":{"id":"doi:10.1109/vecims.2009.5068878","is_oa":false,"landing_page_url":"https://doi.org/10.1109/vecims.2009.5068878","pdf_url":null,"source":{"id":"https://openalex.org/S4210169068","display_name":"Proceedings of the ... IEEE International Conference on Virtual Environments, Human-Computer Interfaces and Measurement Systems./Proceedings of the ... IEEE International Conference on Virtual Environments, Human-Computer Interfaces and Measurement Systems","issn_l":"1944-9410","issn":["1944-9410","1944-9429"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Conference on Virtual Environments, Human-Computer Interfaces and Measurements Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028943520","display_name":"Binil Starly","orcid":"https://orcid.org/0000-0002-8527-1269"},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Binil Starly","raw_affiliation_strings":["School of Industrial Engineering Shape Engineering and Advanced Manufacturing (SEAM), University of Oklahama, Norman, OK, USA"],"affiliations":[{"raw_affiliation_string":"School of Industrial Engineering Shape Engineering and Advanced Manufacturing (SEAM), University of Oklahama, Norman, OK, USA","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113631969","display_name":"Shih Feng Lan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shih Feng Lan","raw_affiliation_strings":["Bioengineering Center Laboratory of Engineering Living Tissue Systems, University of Oklahama, Norman, OK, USA"],"affiliations":[{"raw_affiliation_string":"Bioengineering Center Laboratory of Engineering Living Tissue Systems, University of Oklahama, Norman, OK, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028943520"],"corresponding_institution_ids":["https://openalex.org/I8692664"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.28369272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"123","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9742000102996826,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9729999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-activity","display_name":"Metabolic activity","score":0.7057796716690063},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.6360659599304199},{"id":"https://openalex.org/keywords/collagen-fiber","display_name":"Collagen fiber","score":0.588374137878418},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5617536902427673},{"id":"https://openalex.org/keywords/optical-fiber","display_name":"Optical fiber","score":0.546999990940094},{"id":"https://openalex.org/keywords/limiting-oxygen-concentration","display_name":"Limiting oxygen concentration","score":0.5450809001922607},{"id":"https://openalex.org/keywords/viability-assay","display_name":"Viability assay","score":0.4956914186477661},{"id":"https://openalex.org/keywords/fiber","display_name":"Fiber","score":0.483134001493454},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.45822983980178833},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.448851615190506},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3554016351699829},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3323129415512085},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.318560928106308},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3043038845062256},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2802453637123108},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19549670815467834},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1749950647354126},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.15790051221847534},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.1243731677532196},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09442222118377686},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.08088532090187073}],"concepts":[{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.7057796716690063},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.6360659599304199},{"id":"https://openalex.org/C2993866533","wikidata":"https://www.wikidata.org/wiki/Q26868","display_name":"Collagen fiber","level":2,"score":0.588374137878418},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5617536902427673},{"id":"https://openalex.org/C194232370","wikidata":"https://www.wikidata.org/wiki/Q162","display_name":"Optical fiber","level":2,"score":0.546999990940094},{"id":"https://openalex.org/C89169090","wikidata":"https://www.wikidata.org/wiki/Q593204","display_name":"Limiting oxygen concentration","level":3,"score":0.5450809001922607},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4956914186477661},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.483134001493454},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45822983980178833},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.448851615190506},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3554016351699829},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3323129415512085},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.318560928106308},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3043038845062256},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2802453637123108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19549670815467834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1749950647354126},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.15790051221847534},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1243731677532196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09442222118377686},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.08088532090187073},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/vecims.2009.5068878","is_oa":false,"landing_page_url":"https://doi.org/10.1109/vecims.2009.5068878","pdf_url":null,"source":{"id":"https://openalex.org/S4210169068","display_name":"Proceedings of the ... IEEE International Conference on Virtual Environments, Human-Computer Interfaces and Measurement Systems./Proceedings of the ... IEEE International Conference on Virtual Environments, Human-Computer Interfaces and Measurement Systems","issn_l":"1944-9410","issn":["1944-9410","1944-9429"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE International Conference on Virtual Environments, Human-Computer Interfaces and Measurements Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W49175325","https://openalex.org/W70745157","https://openalex.org/W104918476","https://openalex.org/W147432291","https://openalex.org/W1969729622","https://openalex.org/W1977934318","https://openalex.org/W1977981164","https://openalex.org/W2006914719","https://openalex.org/W2013944399","https://openalex.org/W2023809101","https://openalex.org/W2030744726","https://openalex.org/W2036680047","https://openalex.org/W2038003361","https://openalex.org/W2058580259","https://openalex.org/W2064883171","https://openalex.org/W2094111146","https://openalex.org/W2094823827","https://openalex.org/W2100809477","https://openalex.org/W2104614346","https://openalex.org/W2107596763","https://openalex.org/W2112689444","https://openalex.org/W2134159434","https://openalex.org/W2141431753","https://openalex.org/W2147002266","https://openalex.org/W2157505268","https://openalex.org/W2174682170","https://openalex.org/W6685000978"],"related_works":["https://openalex.org/W4385687789","https://openalex.org/W2949991425","https://openalex.org/W2059634348","https://openalex.org/W2377741953","https://openalex.org/W3160550515","https://openalex.org/W2517400247","https://openalex.org/W4224437047","https://openalex.org/W3164376613","https://openalex.org/W1974086110","https://openalex.org/W2150837293"],"abstract_inverted_index":{"Advancements":[0],"in":[1,36,78],"fiber":[2],"optic":[3],"sensors":[4],"have":[5,29,94],"made":[6],"it":[7],"possible":[8],"for":[9,20,44],"measuring":[10],"biochemical":[11],"parameters":[12],"such":[13],"as":[14,118,142],"oxygen,":[15],"glucose,":[16],"and":[17,55,84,151],"aminoacids":[18],"necessary":[19],"viable":[21],"engineered":[22],"tissue":[23],"growth.":[24],"In":[25],"this":[26],"study,":[27],"we":[28],"devised":[30],"an":[31,119],"experimental":[32],"protocol":[33],"to":[34,98,122,147],"measure":[35],"real-time,":[37],"the":[38,66,88,100,103,107,124,131],"Oxygen":[39],"Uptake":[40],"Rate":[41],"(OUR)":[42],"values":[43],"HEPG2":[45,71],"liver":[46],"cells":[47,72,105,128],"when":[48],"grown":[49],"a)":[50],"on":[51],"cover":[52],"glass":[53],"slides;":[54],"b)":[56],"encapsulated":[57,104,129],"within":[58,106,130],"alginate":[59,108],"based":[60],"hydrogel":[61,132],"matrices.":[62,109],"For":[63],"both":[64],"cases,":[65],"oxygen":[67],"uptake":[68],"rates":[69],"of":[70,102,127],"at":[73],"selected":[74],"time":[75],"points":[76],"varied":[77],"close":[79],"co-relation":[80],"with":[81],"cell":[82,149],"proliferation":[83],"metabolic":[85,125],"activity":[86,126],"during":[87],"7-day":[89],"culture":[90],"period.":[91],"Microscopy":[92],"studies":[93],"also":[95,136],"been":[96],"conducted":[97],"assess":[99,123],"viability":[101],"This":[110],"investigation":[111],"concludes":[112],"that":[113],"OUR":[114],"can":[115],"be":[116],"used":[117],"indicative":[120],"parameter":[121],"matrix.":[133],"The":[134],"study":[135],"presents":[137],"a":[138,143],"fiber-optic":[139],"sensing":[140],"technology":[141],"non-invasive":[144],"diagnostic":[145],"tool":[146],"monitor":[148],"behavior":[150],"activity.":[152]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}