{"id":"https://openalex.org/W2038984635","doi":"https://doi.org/10.1109/vast.2014.7042485","title":"Visual analysis of patterns in multiple amino acid mutation graphs","display_name":"Visual analysis of patterns in multiple amino acid mutation graphs","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2038984635","doi":"https://doi.org/10.1109/vast.2014.7042485","mag":"2038984635"},"language":"en","primary_location":{"id":"doi:10.1109/vast.2014.7042485","is_oa":false,"landing_page_url":"https://doi.org/10.1109/vast.2014.7042485","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE Conference on Visual Analytics Science and Technology (VAST)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029074262","display_name":"Olav Lenz","orcid":null},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Olav Lenz","raw_affiliation_strings":["GRIS, TU, Darmstadt","GRIS, TU Darmstadt,"],"affiliations":[{"raw_affiliation_string":"GRIS, TU, Darmstadt","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"GRIS, TU Darmstadt,","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059641706","display_name":"Frank Keul","orcid":null},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Keul","raw_affiliation_strings":["Computational Biology, TU, Darmstadt","Computational Biology, TU Darmstadt"],"affiliations":[{"raw_affiliation_string":"Computational Biology, TU, Darmstadt","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"Computational Biology, TU Darmstadt","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051532808","display_name":"Sebastian Bremm","orcid":null},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Bremm","raw_affiliation_strings":["GRIS, TU, Darmstadt","GRIS, TU Darmstadt,"],"affiliations":[{"raw_affiliation_string":"GRIS, TU, Darmstadt","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"GRIS, TU Darmstadt,","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063890041","display_name":"Kay Hamacher","orcid":"https://orcid.org/0000-0002-6921-8345"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kay Hamacher","raw_affiliation_strings":["Computational Biology, TU, Darmstadt","Computational Biology, TU Darmstadt"],"affiliations":[{"raw_affiliation_string":"Computational Biology, TU, Darmstadt","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"Computational Biology, TU Darmstadt","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015182248","display_name":"Tatiana von Landesberger","orcid":"https://orcid.org/0000-0002-5279-1444"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technical University of Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tatiana von Landesberger","raw_affiliation_strings":["GRIS, TU, Darmstadt","GRIS, TU Darmstadt,"],"affiliations":[{"raw_affiliation_string":"GRIS, TU, Darmstadt","institution_ids":["https://openalex.org/I31512782"]},{"raw_affiliation_string":"GRIS, TU Darmstadt,","institution_ids":["https://openalex.org/I31512782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029074262"],"corresponding_institution_ids":["https://openalex.org/I31512782"],"apc_list":null,"apc_paid":null,"fwci":0.9885,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.80267289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"298","issue":null,"first_page":"93","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10799","display_name":"Data Visualization and Analytics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10799","display_name":"Data Visualization and Analytics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.968500018119812,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6654164791107178},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5485504269599915},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49890780448913574},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.48843851685523987},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.47187891602516174},{"id":"https://openalex.org/keywords/directed-acyclic-graph","display_name":"Directed acyclic graph","score":0.4474751651287079},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.43649348616600037},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.4351217448711395},{"id":"https://openalex.org/keywords/mutation-testing","display_name":"Mutation testing","score":0.43196558952331543},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3373476266860962},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.31631049513816833},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3093109130859375},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24471449851989746},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.22048354148864746},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08835390210151672}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6654164791107178},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5485504269599915},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49890780448913574},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.48843851685523987},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.47187891602516174},{"id":"https://openalex.org/C74197172","wikidata":"https://www.wikidata.org/wiki/Q1195339","display_name":"Directed acyclic graph","level":2,"score":0.4474751651287079},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.43649348616600037},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4351217448711395},{"id":"https://openalex.org/C163565370","wikidata":"https://www.wikidata.org/wiki/Q4308623","display_name":"Mutation testing","level":4,"score":0.43196558952331543},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3373476266860962},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31631049513816833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3093109130859375},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24471449851989746},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.22048354148864746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08835390210151672},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/vast.2014.7042485","is_oa":false,"landing_page_url":"https://doi.org/10.1109/vast.2014.7042485","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 IEEE Conference on Visual Analytics Science and Technology (VAST)","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.686.6419","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.686.6419","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.gris.tu-darmstadt.de/research/vissearch/publications/pdf/PrePrint_VAST2014bionetwork.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.717.8712","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.717.8712","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.gris.tu-darmstadt.de/research/vissearch/projects/mutation/VAST2014bionetwork.pdf","raw_type":"text"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:108985","is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/108985/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Konferenzver\u00f6ffentlichung"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W229097380","https://openalex.org/W241117969","https://openalex.org/W1489443448","https://openalex.org/W1498018581","https://openalex.org/W1502432690","https://openalex.org/W1553420678","https://openalex.org/W1940958011","https://openalex.org/W1967066104","https://openalex.org/W1971458834","https://openalex.org/W1972291833","https://openalex.org/W1976722121","https://openalex.org/W1989872317","https://openalex.org/W1994354817","https://openalex.org/W2004559608","https://openalex.org/W2017248899","https://openalex.org/W2020098460","https://openalex.org/W2020106188","https://openalex.org/W2021553191","https://openalex.org/W2024290096","https://openalex.org/W2026409863","https://openalex.org/W2029667189","https://openalex.org/W2050451614","https://openalex.org/W2059018062","https://openalex.org/W2064854394","https://openalex.org/W2071353749","https://openalex.org/W2071601050","https://openalex.org/W2072847827","https://openalex.org/W2074494141","https://openalex.org/W2080526455","https://openalex.org/W2085369494","https://openalex.org/W2089852907","https://openalex.org/W2094308071","https://openalex.org/W2102346146","https://openalex.org/W2105893525","https://openalex.org/W2112262143","https://openalex.org/W2112426855","https://openalex.org/W2124533460","https://openalex.org/W2129187661","https://openalex.org/W2130921644","https://openalex.org/W2133063320","https://openalex.org/W2136834339","https://openalex.org/W2144636447","https://openalex.org/W2148312898","https://openalex.org/W2150215096","https://openalex.org/W2152621157","https://openalex.org/W2153624566","https://openalex.org/W2158453355","https://openalex.org/W2168209541","https://openalex.org/W2582743722","https://openalex.org/W2898709021","https://openalex.org/W4255938757","https://openalex.org/W4297914773","https://openalex.org/W6608852248","https://openalex.org/W6629203620","https://openalex.org/W6629820112","https://openalex.org/W6630163099","https://openalex.org/W6682474454"],"related_works":["https://openalex.org/W4302345037","https://openalex.org/W2731094954","https://openalex.org/W2789273959","https://openalex.org/W2952978498","https://openalex.org/W1998712144","https://openalex.org/W4292730466","https://openalex.org/W2951616510","https://openalex.org/W2068608913","https://openalex.org/W3122467582","https://openalex.org/W2599067389"],"abstract_inverted_index":{"Proteins":[0],"are":[1,76],"essential":[2],"parts":[3],"in":[4,28,44,60,107,135,152,181,186],"all":[5],"living":[6],"organisms.":[7],"They":[8],"consist":[9],"of":[10,12,97,130,171],"sequences":[11],"amino":[13,42,74,84],"acids.":[14],"An":[15],"interaction":[16],"with":[17,213],"reactive":[18],"agent":[19],"can":[20,197],"stimulate":[21],"a":[22,25,36,69,121,140,207,221],"mutation":[23,32,64,80,90,136,154,183],"at":[24],"specific":[26],"position":[27],"the":[29,45,125,128,172,178,182,187],"sequence.":[30],"This":[31],"may":[33,55,86],"set":[34,225],"off":[35],"chain":[37,65],"reaction,":[38],"which":[39],"effects":[40,59],"other":[41],"acids":[43,75],"protein.":[46],"Chain":[47],"reactions":[48],"need":[49,100],"to":[50,101],"be":[51,198],"analyzed,":[52],"as":[53,203],"they":[54],"invoke":[56],"unwanted":[57],"side":[58],"drug":[61],"treatment.":[62],"A":[63],"is":[66],"represented":[67],"by":[68,78],"directed":[70,160],"acyclic":[71,159],"graph,":[72],"where":[73],"connected":[77],"their":[79],"dependencies.":[81],"As":[82],"each":[83],"acid":[85],"mutate":[87],"individually,":[88],"many":[89,153,157],"graphs":[91,155,184],"exist.":[92],"To":[93],"determine":[94],"important":[95],"impacts":[96],"mutations,":[98],"experts":[99],"analyze":[102],"and":[103,127,169,185],"compare":[104],"common":[105],"patterns":[106,132,151,180,196,201],"these":[108],"mutations":[109],"graphs.":[110,137],"Experts,":[111],"however,":[112],"lack":[113],"suitable":[114],"tools":[115],"for":[116,124,147,206,219],"this":[117,192],"purpose.":[118],"We":[119,138],"present":[120,139],"new":[122],"system":[123,164],"search":[126,143],"exploration":[129,168],"frequent":[131],"(i.e.,":[133,156],"motifs)":[134],"fast":[141],"pattern":[142],"algorithm":[144],"specifically":[145],"developed":[146],"finding":[148],"biologically":[149],"relevant":[150],"labeled":[158],"graphs).":[161],"Our":[162],"visualization":[163],"allows":[165],"an":[166],"interactive":[167],"comparison":[170],"found":[173,179],"patterns.":[174],"It":[175],"enables":[176],"locating":[177],"3D":[188],"protein":[189],"structures.":[190],"In":[191,211],"way,":[193],"potentially":[194],"interesting":[195],"discovered.":[199],"These":[200],"serve":[202],"starting":[204],"point":[205],"further":[208],"biological":[209],"analysis.":[210],"cooperation":[212],"biologists,":[214],"we":[215],"use":[216],"our":[217],"approach":[218],"analyzing":[220],"real":[222],"world":[223],"data":[224],"based":[226],"on":[227],"multiple":[228],"HIV":[229],"protease":[230],"sequences.":[231]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
