{"id":"https://openalex.org/W1976095922","doi":"https://doi.org/10.1109/urai.2013.6677497","title":"Microfluidic device for automated generation of toroidal-like spheroids","display_name":"Microfluidic device for automated generation of toroidal-like spheroids","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1976095922","doi":"https://doi.org/10.1109/urai.2013.6677497","mag":"1976095922"},"language":"en","primary_location":{"id":"doi:10.1109/urai.2013.6677497","is_oa":false,"landing_page_url":"https://doi.org/10.1109/urai.2013.6677497","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 10th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111761020","display_name":"Hirochika Takai","orcid":null},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirochika Takai","raw_affiliation_strings":["Graduate School of Engineering Science, Osaka University, Osaka, Japan","Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering Science, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000726773","display_name":"Masaru Kojima","orcid":"https://orcid.org/0000-0002-1314-3540"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Kojima","raw_affiliation_strings":["Graduate School of Engineering Science, Osaka University, Osaka, Japan","Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering Science, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025950008","display_name":"Kenichi Ohara","orcid":"https://orcid.org/0000-0003-1712-3245"},"institutions":[{"id":"https://openalex.org/I96636082","display_name":"Meijo University","ror":"https://ror.org/04h42fc75","country_code":"JP","type":"education","lineage":["https://openalex.org/I96636082"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Ohara","raw_affiliation_strings":["Faculty of Science and Technology, Meijo University, Nagoya, Aichi, Japan","Fac. of Sci. & Technol., Meijo Univ., Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Meijo University, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I96636082"]},{"raw_affiliation_string":"Fac. of Sci. & Technol., Meijo Univ., Nagoya, Japan","institution_ids":["https://openalex.org/I96636082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007358152","display_name":"Mitsuhiro Horade","orcid":"https://orcid.org/0000-0002-7707-4230"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Horade","raw_affiliation_strings":["Graduate School of Engineering Science, Osaka University, Osaka, Japan","Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering Science, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018868216","display_name":"Tamio Tanikawa","orcid":"https://orcid.org/0000-0003-3479-4585"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tamio Tanikawa","raw_affiliation_strings":["Intelligent System Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan","Intell. Syst. Res. Inst., Nat. Inst. of Adv. Ind. Sci. & Technol., Tsukuba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intelligent System Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I73613424"]},{"raw_affiliation_string":"Intell. Syst. Res. Inst., Nat. Inst. of Adv. Ind. Sci. & Technol., Tsukuba, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044203013","display_name":"Yasushi Mae","orcid":null},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Mae","raw_affiliation_strings":["Graduate School of Engineering Science, Osaka University, Osaka, Japan","Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering Science, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021209820","display_name":"Masayuki Yamato","orcid":"https://orcid.org/0000-0002-3146-1024"},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Yamato","raw_affiliation_strings":["Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Shinjuku, Tokyo, Japan","Instiuue of Adv. Biomed. Eng. & Sci., Tokyo Women's Med. Univ. (TWIns), Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University (TWIns), Shinjuku, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]},{"raw_affiliation_string":"Instiuue of Adv. Biomed. Eng. & Sci., Tokyo Women's Med. Univ. (TWIns), Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017331725","display_name":"Tatsuo Arai","orcid":"https://orcid.org/0000-0001-7863-5696"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Arai","raw_affiliation_strings":["Graduate School of Engineering Science, Osaka University, Osaka, Japan","Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering Science, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Grad. Sch. of Eng. Sci., Osaka Univ., Toyonaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2052,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5544583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"140","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12776","display_name":"Electrohydrodynamics and Fluid Dynamics","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7741348743438721},{"id":"https://openalex.org/keywords/spheroid","display_name":"Spheroid","score":0.7006462216377258},{"id":"https://openalex.org/keywords/toroid","display_name":"Toroid","score":0.686570405960083},{"id":"https://openalex.org/keywords/fluidics","display_name":"Fluidics","score":0.6712664365768433},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.5616231560707092},{"id":"https://openalex.org/keywords/rotational-speed","display_name":"Rotational speed","score":0.5460720658302307},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.5412026047706604},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.4899980127811432},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.48871612548828125},{"id":"https://openalex.org/keywords/centrifugal-force","display_name":"Centrifugal force","score":0.4451757073402405},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3024711608886719},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.23970860242843628},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20956775546073914},{"id":"https://openalex.org/keywords/aerospace-engineering","display_name":"Aerospace engineering","score":0.1434655785560608},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.11088433861732483}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7741348743438721},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.7006462216377258},{"id":"https://openalex.org/C15001198","wikidata":"https://www.wikidata.org/wiki/Q3241394","display_name":"Toroid","level":3,"score":0.686570405960083},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.6712664365768433},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.5616231560707092},{"id":"https://openalex.org/C81063470","wikidata":"https://www.wikidata.org/wiki/Q1256787","display_name":"Rotational speed","level":2,"score":0.5460720658302307},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.5412026047706604},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.4899980127811432},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48871612548828125},{"id":"https://openalex.org/C50735335","wikidata":"https://www.wikidata.org/wiki/Q178733","display_name":"Centrifugal force","level":3,"score":0.4451757073402405},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3024711608886719},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23970860242843628},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20956775546073914},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.1434655785560608},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11088433861732483},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/urai.2013.6677497","is_oa":false,"landing_page_url":"https://doi.org/10.1109/urai.2013.6677497","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 10th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1965032077","https://openalex.org/W2028500339","https://openalex.org/W2041052342","https://openalex.org/W2046092624","https://openalex.org/W2046901824","https://openalex.org/W2074708388","https://openalex.org/W2122920174","https://openalex.org/W2125987139","https://openalex.org/W2575591446","https://openalex.org/W4211147424"],"related_works":["https://openalex.org/W2050956753","https://openalex.org/W2184533732","https://openalex.org/W2034330200","https://openalex.org/W3045873720","https://openalex.org/W1851983721","https://openalex.org/W4280524709","https://openalex.org/W2039512842","https://openalex.org/W3089091447","https://openalex.org/W2746463958","https://openalex.org/W4311960286"],"abstract_inverted_index":{"In":[0,146],"the":[1,33,52,81,92,105,125,156],"field":[2],"of":[3,13,35,37,41,48,62,76,80,94,136,149],"tissue":[4],"engineering,":[5],"it":[6],"is":[7,64,102],"called":[8],"for":[9,26],"to":[10,87,155],"automate":[11],"generation":[12,47,135],"various-shaped":[14],"spheroids.":[15],"We":[16,111],"propose":[17],"a":[18,68],"micro":[19,82],"fluidic":[20,83],"device":[21,53,84],"that":[22,99],"generates":[23],"rotational":[24,49,77,100,137],"flow":[25,50,70,95,101,106,138],"producing":[27],"toroidal-like":[28,38],"spheroid.":[29],"This":[30],"paper":[31],"reports":[32],"concept":[34],"construction":[36,63],"spheroid,":[39],"designs":[40],"microchannels,":[42],"and":[43,56,91,124,134],"fundamental":[44],"verification":[45],"about":[46],"in":[51,67,141],"using":[54,58,73,144],"simulation":[55,96],"experiment":[57,143],"created":[59],"microchannels.":[60],"Concept":[61],"non-contact":[65],"operation":[66],"continuous":[69],"stimulus":[71],"by":[72,130],"centrifugal":[74],"force":[75],"flow.":[78],"Designs":[79],"was":[85,119,128,139],"optimized":[86],"generate":[88],"micro-rotational":[89],"flow,":[90],"results":[93],"models":[97],"show":[98],"generated":[103],"at":[104],"velocity":[107],"more":[108],"than":[109],"fixed.":[110],"made":[112,120,129],"these":[113],"designs.":[114],"The":[115],"large":[116],"size":[117],"channel":[118,127],"with":[121],"3D":[122],"printer":[123],"small":[126],"poly-dimethysiloxane":[131],"(PDMS)":[132],"molding,":[133],"observed":[140],"an":[142],"particles.":[145],"both":[147],"types":[148],"channels,":[150],"particles":[151],"were":[152],"rotated":[153],"similar":[154],"simulations.":[157]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}