{"id":"https://openalex.org/W3204704144","doi":"https://doi.org/10.1109/tvcg.2021.3116656","title":"DXplorer: A Unified Visualization Framework for Interactive Dendritic Spine Analysis Using 3D Morphological Features","display_name":"DXplorer: A Unified Visualization Framework for Interactive Dendritic Spine Analysis Using 3D Morphological Features","publication_year":2021,"publication_date":"2021-09-30","ids":{"openalex":"https://openalex.org/W3204704144","doi":"https://doi.org/10.1109/tvcg.2021.3116656","mag":"3204704144","pmid":"https://pubmed.ncbi.nlm.nih.gov/34591770"},"language":"en","primary_location":{"id":"doi:10.1109/tvcg.2021.3116656","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tvcg.2021.3116656","pdf_url":null,"source":{"id":"https://openalex.org/S84775595","display_name":"IEEE Transactions on Visualization and Computer Graphics","issn_l":"1077-2626","issn":["1077-2626","1941-0506","2160-9306"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Visualization and Computer Graphics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087518165","display_name":"Junyoung Choi","orcid":"https://orcid.org/0000-0002-4255-4402"},"institutions":[{"id":"https://openalex.org/I48566637","display_name":"Ulsan National Institute of Science and Technology","ror":"https://ror.org/017cjz748","country_code":"KR","type":"education","lineage":["https://openalex.org/I48566637"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"JunYoung Choi","raw_affiliation_strings":["Ulsan National Institute of Science and Technology, Ulsan, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-4255-4402","affiliations":[{"raw_affiliation_string":"Ulsan National Institute of Science and Technology, Ulsan, South Korea","institution_ids":["https://openalex.org/I48566637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755143","display_name":"Sang\u2010Eun Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Eun Lee","raw_affiliation_strings":["Seoul National University College of Medicine, Seoul, South Korea"],"raw_orcid":"https://orcid.org/0000-0001-7371-8556","affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102327712","display_name":"Yein Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YeIn Lee","raw_affiliation_strings":["Korea University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea University, Seoul, South Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464858","display_name":"Eunji Cho","orcid":"https://orcid.org/0000-0002-8486-3641"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunji Cho","raw_affiliation_strings":["Seoul National University College of Medicine, Seoul, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-8486-3641","affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046016624","display_name":"Sunghoe Chang","orcid":"https://orcid.org/0000-0002-3446-7288"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunghoe Chang","raw_affiliation_strings":["Seoul National University College of Medicine, Seoul, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-3446-7288","affiliations":[{"raw_affiliation_string":"Seoul National University College of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025485089","display_name":"Won\u2010Ki Jeong","orcid":"https://orcid.org/0000-0002-9393-6451"},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won-Ki Jeong","raw_affiliation_strings":["Korea University, Seoul, South Korea"],"raw_orcid":"https://orcid.org/0000-0002-9393-6451","affiliations":[{"raw_affiliation_string":"Korea University, Seoul, South Korea","institution_ids":["https://openalex.org/I197347611"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5087518165"],"corresponding_institution_ids":["https://openalex.org/I48566637"],"apc_list":null,"apc_paid":null,"fwci":3.4789,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.92647481,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"29","issue":"2","first_page":"1424","last_page":"1437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10481","display_name":"Computer Graphics and Visualization Techniques","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1704","display_name":"Computer Graphics and Computer-Aided Design"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spine","display_name":"Dendritic spine","score":0.8738799691200256},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7529953122138977},{"id":"https://openalex.org/keywords/spine","display_name":"SPINE (molecular biology)","score":0.5948843359947205},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.5786963105201721},{"id":"https://openalex.org/keywords/rendering","display_name":"Rendering (computer graphics)","score":0.5325896739959717},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.43897098302841187},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.168554425239563},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.16596993803977966},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15726229548454285}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.8738799691200256},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7529953122138977},{"id":"https://openalex.org/C205383261","wikidata":"https://www.wikidata.org/wiki/Q7392570","display_name":"SPINE (molecular biology)","level":2,"score":0.5948843359947205},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.5786963105201721},{"id":"https://openalex.org/C205711294","wikidata":"https://www.wikidata.org/wiki/Q176953","display_name":"Rendering (computer graphics)","level":2,"score":0.5325896739959717},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.43897098302841187},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.168554425239563},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16596993803977966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15726229548454285},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/tvcg.2021.3116656","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tvcg.2021.3116656","pdf_url":null,"source":{"id":"https://openalex.org/S84775595","display_name":"IEEE Transactions on Visualization and Computer Graphics","issn_l":"1077-2626","issn":["1077-2626","1941-0506","2160-9306"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Visualization and Computer Graphics","raw_type":"journal-article"},{"id":"pmid:34591770","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34591770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on visualization and computer graphics","raw_type":null},{"id":"pmh:oai:s-space.snu.ac.kr:10371/183901","is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/183901","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:scholarworks.unist.ac.kr:201301/62278","is_oa":false,"landing_page_url":"https://scholarworks.unist.ac.kr/handle/201301/62278","pdf_url":null,"source":{"id":"https://openalex.org/S4306401118","display_name":"Scholarworks@UNIST (Ulsan National Institute of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I48566637","host_organization_name":"Ulsan National Institute of Science and Technology","host_organization_lineage":["https://openalex.org/I48566637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"ARTICLE"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/4","score":0.5199999809265137,"display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G1815469667","display_name":null,"funder_award_id":"NRF-2017M3C7A1047904","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G623612411","display_name":null,"funder_award_id":"NRF-2021R1A6A1A13044830","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7594979816","display_name":null,"funder_award_id":"NRF-2019M3E5D2A01063819","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W150863633","https://openalex.org/W1592074189","https://openalex.org/W1596717185","https://openalex.org/W1782145433","https://openalex.org/W1984224738","https://openalex.org/W1989961182","https://openalex.org/W2000214666","https://openalex.org/W2007706380","https://openalex.org/W2012820019","https://openalex.org/W2036272879","https://openalex.org/W2040268226","https://openalex.org/W2060300932","https://openalex.org/W2063773908","https://openalex.org/W2100084621","https://openalex.org/W2101234009","https://openalex.org/W2111155182","https://openalex.org/W2119570806","https://openalex.org/W2124683806","https://openalex.org/W2126589366","https://openalex.org/W2127861262","https://openalex.org/W2141569821","https://openalex.org/W2143175740","https://openalex.org/W2151123745","https://openalex.org/W2231709936","https://openalex.org/W2401688019","https://openalex.org/W2594961991","https://openalex.org/W2616137712","https://openalex.org/W2751305043","https://openalex.org/W2752985888","https://openalex.org/W2762204783","https://openalex.org/W2794273838","https://openalex.org/W2805782030","https://openalex.org/W2807802914","https://openalex.org/W2889326414","https://openalex.org/W2923798092","https://openalex.org/W2972845140","https://openalex.org/W3004825607","https://openalex.org/W3151224251","https://openalex.org/W4212819269","https://openalex.org/W4298082496","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W2169505641","https://openalex.org/W1996493542","https://openalex.org/W2120160245","https://openalex.org/W3132088562","https://openalex.org/W2136747326","https://openalex.org/W1989838035","https://openalex.org/W2151123745","https://openalex.org/W2528820646","https://openalex.org/W4317935580","https://openalex.org/W2171612971"],"abstract_inverted_index":{"Dendritic":[0],"spines":[1,63,86,100,126,148,155],"are":[2,26,51,64],"dynamic,":[3],"submicron-scale":[4],"protrusions":[5],"on":[6,66,102,157,202],"neuronal":[7,11],"dendrites":[8],"that":[9,121,227],"receive":[10],"inputs.":[12],"Morphological":[13],"changes":[14],"in":[15,22,54],"the":[16,35,73,129,134,145,203,218,223,228,231],"dendritic":[17,62,116,154,174],"spine":[18,49,117,204],"often":[19],"reflect":[20,72],"alterations":[21],"physiological":[23],"conditions":[24],"and":[25,38,45,98,127,150,152,186,209,220,236,240],"indicators":[27],"of":[28,41,48,125,137,147,164,173,222],"various":[29,88],"neuropsychiatric":[30],"conditions.":[31],"However,":[32],"owing":[33],"to":[34,84,95,215],"highly":[36],"dynamic":[37],"heterogeneous":[39],"nature":[40],"spines,":[42],"accurate":[43],"measurement":[44],"objective":[46,241],"analysis":[47,118],"morphology":[50],"major":[52],"challenges":[53],"neuroscience":[55],"research.":[56],"Most":[57],"conventional":[58],"approaches":[59],"for":[60,112],"analyzing":[61],"based":[65,101,156,201],"two-dimensional":[67],"(2D)":[68],"images,":[69],"which":[70],"barely":[71],"actual":[74],"three-dimensional":[75],"(3D)":[76],"shapes.":[77],"Although":[78],"some":[79],"recent":[80],"studies":[81,212],"have":[82],"attempted":[83],"analyze":[85,99,153],"with":[87,183],"3D-based":[89],"features,":[90],"it":[91],"is":[92],"still":[93],"difficult":[94],"objectively":[96],"categorize":[97],"3D":[103,115,123,135,171,192],"morphology.":[104],"Here,":[105],"we":[106],"propose":[107,161],"a":[108,162,170,197],"unified":[109],"visualization":[110],"framework":[111],"an":[113,178,190],"interactive":[114,179,191],"system,":[119,141],"DXplorer,":[120],"displays":[122],"rendering":[124],"plots":[128],"high-dimensional":[130,158,165],"features":[131,167],"extracted":[132,168],"from":[133,169],"mesh":[136,172,193],"spines.":[138,175],"With":[139],"this":[140],"users":[142],"can":[143],"perform":[144],"clustering":[146],"interactively":[149],"explore":[151],"features.":[159],"We":[160,225],"series":[163],"morphological":[166],"In":[176],"addition,":[177],"machine":[180],"learning":[181],"classifier":[182],"visual":[184],"exploration":[185],"user":[187,207],"feedback":[188],"using":[189],"grid":[194],"view":[195],"ensures":[196],"more":[198],"precise":[199],"classification":[200],"phenotype.":[205],"A":[206],"study":[208],"two":[210],"case":[211],"were":[213],"conducted":[214],"quantitatively":[216],"verify":[217],"performance":[219],"usability":[221],"DXplorer.":[224],"demonstrate":[226],"system":[229],"performs":[230],"entire":[232],"analytic":[233],"process":[234],"effectively":[235],"provides":[237],"high-quality,":[238],"accurate,":[239],"analysis.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2}],"updated_date":"2026-06-03T09:05:47.796612","created_date":"2025-10-10T00:00:00"}
