{"id":"https://openalex.org/W1990028112","doi":"https://doi.org/10.1109/tsmca.2012.2199302","title":"A New Method for Preliminary Identification of Gene Regulatory Networks from Gene Microarray Cancer Data Using Ridge Partial Least Squares With Recursive Feature Elimination and Novel Brier and Occurrence Probability Measures","display_name":"A New Method for Preliminary Identification of Gene Regulatory Networks from Gene Microarray Cancer Data Using Ridge Partial Least Squares With Recursive Feature Elimination and Novel Brier and Occurrence Probability Measures","publication_year":2012,"publication_date":"2012-10-12","ids":{"openalex":"https://openalex.org/W1990028112","doi":"https://doi.org/10.1109/tsmca.2012.2199302","mag":"1990028112"},"language":"en","primary_location":{"id":"doi:10.1109/tsmca.2012.2199302","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tsmca.2012.2199302","pdf_url":null,"source":{"id":"https://openalex.org/S4210201610","display_name":"IEEE Transactions on Systems Man and Cybernetics - Part A Systems and Humans","issn_l":"1083-4427","issn":["1083-4427","1558-2426"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Systems, Man, and Cybernetics - Part A: Systems and Humans","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057049452","display_name":"S. C. Chan","orcid":"https://orcid.org/0000-0001-7212-4182"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"S. C. Chan","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China","Dept. of Electr. & Electron. Engg, Univ. of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Dept. of Electr. & Electron. Engg, Univ. of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101830959","display_name":"H. C. Wu","orcid":"https://orcid.org/0000-0002-4555-3675"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"H. C. Wu","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China","Dept. of Electr. & Electron. Engg, Univ. of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Dept. of Electr. & Electron. Engg, Univ. of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012561633","display_name":"K. M. Tsui","orcid":null},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"K. M. Tsui","raw_affiliation_strings":["Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China","Dept. of Electr. & Electron. Engg, Univ. of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Dept. of Electr. & Electron. Engg, Univ. of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":0.5297,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.6406107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"6","first_page":"1514","last_page":"1528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6446951031684875},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6178533434867859},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5175997018814087},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5119096040725708},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.4826353192329407},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4552012085914612},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.4505860209465027},{"id":"https://openalex.org/keywords/brier-score","display_name":"Brier score","score":0.44621050357818604},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4279438853263855},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4231411814689636},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32581818103790283},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3122047185897827},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27155566215515137},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18298473954200745}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6446951031684875},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6178533434867859},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5175997018814087},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5119096040725708},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.4826353192329407},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4552012085914612},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.4505860209465027},{"id":"https://openalex.org/C35405484","wikidata":"https://www.wikidata.org/wiki/Q4967066","display_name":"Brier score","level":2,"score":0.44621050357818604},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4279438853263855},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4231411814689636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32581818103790283},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3122047185897827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27155566215515137},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18298473954200745},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/tsmca.2012.2199302","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tsmca.2012.2199302","pdf_url":null,"source":{"id":"https://openalex.org/S4210201610","display_name":"IEEE Transactions on Systems Man and Cybernetics - Part A Systems and Humans","issn_l":"1083-4427","issn":["1083-4427","1558-2426"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Systems, Man, and Cybernetics - Part A: Systems and Humans","raw_type":"journal-article"},{"id":"pmh:oai:hub.hku.hk:10722/164063","is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/164063","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1546607196","https://openalex.org/W1554944419","https://openalex.org/W1578780319","https://openalex.org/W1600918697","https://openalex.org/W1868347993","https://openalex.org/W1965392255","https://openalex.org/W1970502168","https://openalex.org/W1976169036","https://openalex.org/W1981648297","https://openalex.org/W2008233371","https://openalex.org/W2012987716","https://openalex.org/W2017337590","https://openalex.org/W2034269086","https://openalex.org/W2044253421","https://openalex.org/W2048192130","https://openalex.org/W2073241381","https://openalex.org/W2073792037","https://openalex.org/W2075951102","https://openalex.org/W2087684630","https://openalex.org/W2096158882","https://openalex.org/W2102062980","https://openalex.org/W2102589238","https://openalex.org/W2107956883","https://openalex.org/W2107998515","https://openalex.org/W2109363337","https://openalex.org/W2113922320","https://openalex.org/W2115358726","https://openalex.org/W2116079122","https://openalex.org/W2116396438","https://openalex.org/W2119411189","https://openalex.org/W2119479037","https://openalex.org/W2123363536","https://openalex.org/W2128557693","https://openalex.org/W2136291495","https://openalex.org/W2141007997","https://openalex.org/W2143426320","https://openalex.org/W2144403317","https://openalex.org/W2145644212","https://openalex.org/W2150831146","https://openalex.org/W2151038079","https://openalex.org/W2157095691","https://openalex.org/W2158137698","https://openalex.org/W2159400887","https://openalex.org/W2163296862","https://openalex.org/W2223040737","https://openalex.org/W2231077521","https://openalex.org/W2401641585","https://openalex.org/W2418748156","https://openalex.org/W2796308790","https://openalex.org/W3125904670","https://openalex.org/W4285719527","https://openalex.org/W6675301529","https://openalex.org/W6679138219","https://openalex.org/W6682985578","https://openalex.org/W6689321350"],"related_works":["https://openalex.org/W1774890144","https://openalex.org/W4293426625","https://openalex.org/W2728311169","https://openalex.org/W3121128755","https://openalex.org/W2051201630","https://openalex.org/W2082471284","https://openalex.org/W2773944606","https://openalex.org/W2043644439","https://openalex.org/W2089861931","https://openalex.org/W3003903795"],"abstract_inverted_index":{"This":[0],"paper":[1],"proposes":[2],"a":[3,48,56,71,86,135,152,220,233],"new":[4],"method":[5],"for":[6,47,61,223,236],"preliminary":[7,40,224],"identification":[8,41,225],"of":[9,42,59,156,167,195,201,226,232],"gene":[10,15,137,183],"regulatory":[11],"networks":[12],"(GRNs)":[13],"from":[14,114,185],"microarray":[16,241],"cancer":[17,171],"databased":[18],"on":[19,54,164],"ridge":[20],"partial":[21],"least":[22],"squares":[23],"(RPLS)":[24],"with":[25],"recursive":[26],"feature":[27],"elimination":[28],"(RFE)":[29],"and":[30,33,45,70,95,150,158,177,193,228],"novel":[31,72,93],"Brier":[32,73,94],"occurrence":[34,96],"probability":[35],"measures.":[36],"It":[37,108],"facilitates":[38],"the":[39,82,121,131,139,165,214],"meaningful":[43],"pathways":[44],"genes":[46,60,103,116,157,227],"specific":[49],"disease,":[50],"rather":[51],"than":[52],"focusing":[53],"selecting":[55],"small":[57,136],"set":[58,155],"classification":[62,133,148],"purposes":[63],"as":[64,219],"in":[65,78,101,120,208],"conventional":[66,127],"studies.":[67],"First,":[68],"RFE":[69],"error":[74],"measure":[75],"are":[76,99,197],"incorporated":[77],"RPLS":[79],"to":[80,110,144,199,205],"reduce":[81],"estimation":[83],"variance":[84],"using":[85,134,240],"two-nested":[87],"cross":[88],"validation":[89],"(CV)":[90],"approach.":[91],"Second,":[92],"probability-based":[97],"measures":[98],"employed":[100],"ranking":[102,122],"across":[104],"different":[105,112,186],"CV":[106],"subsamples.":[107],"helps":[109],"detect":[111],"GRNs":[113,189,231],"correlated":[115],"which":[117],"consistently":[118],"appear":[119],"lists.":[123],"Therefore,":[124],"unlike":[125],"most":[126,194],"approaches":[128],"that":[129,180,213],"emphasize":[130],"best":[132],"set,":[138],"proposed":[140,215],"approach":[141,216],"is":[142],"able":[143],"simultaneously":[145],"offer":[146],"good":[147],"accuracy":[149],"identify":[151],"more":[153],"comprehensive":[154],"their":[159,229],"associated":[160,230],"GRNs.":[161],"Experimental":[162],"results":[163],"analysis":[166],"three":[168],"publicly":[169],"available":[170],"data":[172],"sets,":[173],"namely":[174],"leukemia,":[175],"colon,":[176],"prostate,":[178],"show":[179],"very":[181],"stable":[182],"sets":[184],"but":[187],"relevant":[188],"can":[190],"be":[191,200],"identified,":[192],"them":[196],"found":[198],"biological":[202,209,238],"significance":[203],"according":[204],"previous":[206],"findings":[207],"experiments.":[210],"These":[211],"suggest":[212],"may":[217],"serve":[218],"useful":[221],"tool":[222],"particular":[234],"disease":[235],"further":[237],"studies":[239],"or":[242],"similar":[243],"data.":[244]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
