{"id":"https://openalex.org/W4408708170","doi":"https://doi.org/10.1109/tnnls.2025.3545101","title":"MSAFF: Multi-Way Soft Attention Fusion Framework With the Large Foundation Models for the Diagnosis of Alzheimer\u2019s Disease","display_name":"MSAFF: Multi-Way Soft Attention Fusion Framework With the Large Foundation Models for the Diagnosis of Alzheimer\u2019s Disease","publication_year":2025,"publication_date":"2025-03-21","ids":{"openalex":"https://openalex.org/W4408708170","doi":"https://doi.org/10.1109/tnnls.2025.3545101","pmid":"https://pubmed.ncbi.nlm.nih.gov/40117152"},"language":"en","primary_location":{"id":"doi:10.1109/tnnls.2025.3545101","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2025.3545101","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048824835","display_name":"Xia-an Bi","orcid":"https://orcid.org/0000-0002-2715-3360"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia-An Bi","raw_affiliation_strings":["College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-2715-3360","affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenzhuo Shen","orcid":"https://orcid.org/0009-0007-6677-4147"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzhuo Shen","raw_affiliation_strings":["College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0007-6677-4147","affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113689269","display_name":"Yinglu Shan","orcid":"https://orcid.org/0009-0002-8708-400X"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinglu Shan","raw_affiliation_strings":["College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0002-8708-400X","affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070471298","display_name":"Dayou Chen","orcid":"https://orcid.org/0000-0001-8616-2657"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dayou Chen","raw_affiliation_strings":["College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luyun Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyun Xu","raw_affiliation_strings":["College of Business, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Business, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086336471","display_name":"Ke Chen","orcid":"https://orcid.org/0000-0003-3511-3112"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Chen","raw_affiliation_strings":["College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering and the Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100413264","display_name":"Zhonghua Liu","orcid":"https://orcid.org/0009-0004-9422-7632"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhonghua Liu","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0004-9422-7632","affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5048824835"],"corresponding_institution_ids":["https://openalex.org/I173759888"],"apc_list":null,"apc_paid":null,"fwci":2.9599,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.90381901,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"36","issue":"10","first_page":"17541","last_page":"17555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foundation","display_name":"Foundation (evidence)","score":0.8249949216842651},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5705238580703735},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.45882391929626465},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45384520292282104},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.41674473881721497},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37356534600257874},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3548530340194702},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3268375098705292},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21761846542358398},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.10758793354034424},{"id":"https://openalex.org/keywords/political-science","display_name":"Political science","score":0.09916815161705017},{"id":"https://openalex.org/keywords/linguistics","display_name":"Linguistics","score":0.0728788673877716}],"concepts":[{"id":"https://openalex.org/C2780966255","wikidata":"https://www.wikidata.org/wiki/Q5474306","display_name":"Foundation (evidence)","level":2,"score":0.8249949216842651},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5705238580703735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45882391929626465},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45384520292282104},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.41674473881721497},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37356534600257874},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3548530340194702},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3268375098705292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21761846542358398},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.10758793354034424},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.09916815161705017},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0728788673877716},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tnnls.2025.3545101","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2025.3545101","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},{"id":"pmid:40117152","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40117152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on neural networks and learning systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1709615817","display_name":null,"funder_award_id":"2023JJ30410","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G4149904471","display_name":null,"funder_award_id":"62372169","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6502659134","display_name":null,"funder_award_id":"62072173","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7890500757","display_name":null,"funder_award_id":"2024RC1049","funder_id":"https://openalex.org/F4320330206","funder_display_name":"Science and Technology Program of Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null},{"id":"https://openalex.org/F4320330206","display_name":"Science and Technology Program of Hunan Province","ror":null},{"id":"https://openalex.org/F4320330458","display_name":"Key Laboratory of Visual Perception and Artificial Intelligence of Hunan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W2109434518","https://openalex.org/W2802278070","https://openalex.org/W2963168174","https://openalex.org/W2991680681","https://openalex.org/W3000666672","https://openalex.org/W3005096117","https://openalex.org/W3007734058","https://openalex.org/W3036591144","https://openalex.org/W3042833587","https://openalex.org/W3104709689","https://openalex.org/W3107955909","https://openalex.org/W3109603562","https://openalex.org/W3111865897","https://openalex.org/W3124190974","https://openalex.org/W3133676353","https://openalex.org/W3153445520","https://openalex.org/W3157129463","https://openalex.org/W3160620539","https://openalex.org/W3165588885","https://openalex.org/W3194335755","https://openalex.org/W3197896048","https://openalex.org/W3201799470","https://openalex.org/W4206046172","https://openalex.org/W4213441629","https://openalex.org/W4214530470","https://openalex.org/W4282915079","https://openalex.org/W4283716944","https://openalex.org/W4286373989","https://openalex.org/W4289825102","https://openalex.org/W4295788789","https://openalex.org/W4302009313","https://openalex.org/W4306319049","https://openalex.org/W4309182233","https://openalex.org/W4311021015","https://openalex.org/W4327677625","https://openalex.org/W4385201870","https://openalex.org/W4387717683","https://openalex.org/W4388967748","https://openalex.org/W4390640504","https://openalex.org/W4391052910","https://openalex.org/W4391099575","https://openalex.org/W4391606322","https://openalex.org/W4391849521","https://openalex.org/W4392109210","https://openalex.org/W4400215638","https://openalex.org/W4404821554"],"related_works":["https://openalex.org/W2381393187","https://openalex.org/W2332779545","https://openalex.org/W2358060160","https://openalex.org/W2035483685","https://openalex.org/W1969764885","https://openalex.org/W596947562","https://openalex.org/W2793937822","https://openalex.org/W2790817834","https://openalex.org/W2777605427","https://openalex.org/W2501983714"],"abstract_inverted_index":{"Complementary":[0],"information":[1],"in":[2,20,27,127,145],"multi-omics":[3,28,51],"data":[4],"are":[5,108],"crucial":[6],"for":[7,81,88,158],"understanding":[8],"the":[9,22,55,128,134,140,159],"pathogenesis":[10,162],"of":[11,57,143,164],"Alzheimer's":[12],"Disease":[13],"(AD).":[14],"However,":[15],"existing":[16],"studies":[17],"face":[18],"challenges":[19],"addressing":[21],"high-level":[23],"noise":[24],"and":[25,49,78,84,124,149,161],"heterogeneity":[26],"data.":[29],"This":[30,72,153],"article":[31,154],"presents":[32],"a":[33,64,92],"novel":[34],"approach":[35],"that":[36],"combines":[37],"large":[38],"foundation":[39],"models":[40],"(LFMs)":[41],"with":[42,99],"soft":[43,69,94,117],"attention":[44,70,76,95,118],"mechanisms":[45],"to":[46,110],"enhance,":[47],"select,":[48],"fuse":[50],"features,":[52],"thereby":[53],"improving":[54],"performance":[56],"disease":[58,147],"classification.":[59],"Specifically,":[60],"we":[61],"first":[62],"propose":[63],"mathematical":[65,129],"model":[66,73],"based":[67],"on":[68,133],"mechanisms.":[71],"employs":[74],"multi-head":[75],"(MHA)":[77],"self-attention":[79],"(SA)":[80],"feature":[82,89,122],"selection,":[83],"uses":[85],"cross-attention":[86],"(CA)":[87],"fusion.":[90],"Then,":[91],"multi-way":[93,116],"fusion":[96,125],"framework":[97],"(MSAFF)":[98],"LFMs":[100,107],"is":[101],"proposed.":[102],"In":[103],"this":[104],"approach,":[105],"biomedical":[106,113],"used":[109],"construct":[111],"low-noise":[112],"features.":[114],"The":[115],"algorithm":[119],"implements":[120],"effective":[121],"selection":[123],"described":[126],"model.":[130],"Experimental":[131],"results":[132],"public":[135],"imaging":[136],"genetics":[137],"datasets":[138],"demonstrate":[139],"advanced":[141],"performances":[142],"MSAFF":[144],"both":[146],"classification":[148],"AD-related":[150],"pathogeny":[151],"discrimination.":[152],"provides":[155],"intelligent":[156],"support":[157],"diagnosis":[160],"research":[163],"AD.":[165],"Our":[166],"code":[167],"can":[168],"be":[169],"accessed":[170],"at":[171],"github.com/fmri123456/MSAFF.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
