{"id":"https://openalex.org/W4408017188","doi":"https://doi.org/10.1109/tnnls.2025.3539006","title":"CPST-GAN: Conditional Probabilistic State Transition Generative Adversarial Network With the Biomedical Large Foundation Models","display_name":"CPST-GAN: Conditional Probabilistic State Transition Generative Adversarial Network With the Biomedical Large Foundation Models","publication_year":2025,"publication_date":"2025-02-27","ids":{"openalex":"https://openalex.org/W4408017188","doi":"https://doi.org/10.1109/tnnls.2025.3539006","pmid":"https://pubmed.ncbi.nlm.nih.gov/40031545"},"language":"en","primary_location":{"id":"doi:10.1109/tnnls.2025.3539006","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2025.3539006","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qiong Wang","orcid":"https://orcid.org/0009-0008-7358-9844"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qiong Wang","raw_affiliation_strings":["Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0008-7358-9844","affiliations":[{"raw_affiliation_string":"Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]},{"raw_affiliation_string":"School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luyun Xu","orcid":"https://orcid.org/0000-0002-9889-7914"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyun Xu","raw_affiliation_strings":["College of Business, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-9889-7914","affiliations":[{"raw_affiliation_string":"College of Business, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113689269","display_name":"Yinglu Shan","orcid":"https://orcid.org/0009-0002-8708-400X"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinglu Shan","raw_affiliation_strings":["Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0002-8708-400X","affiliations":[{"raw_affiliation_string":"Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]},{"raw_affiliation_string":"School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wenzhuo Shen","orcid":"https://orcid.org/0009-0007-6677-4147"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenzhuo Shen","raw_affiliation_strings":["Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0007-6677-4147","affiliations":[{"raw_affiliation_string":"Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]},{"raw_affiliation_string":"School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070268270","display_name":"Lou Li","orcid":null},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lou Li","raw_affiliation_strings":["Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]},{"raw_affiliation_string":"School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048824835","display_name":"Xia-an Bi","orcid":"https://orcid.org/0000-0002-2715-3360"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia-An Bi","raw_affiliation_strings":["Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-2715-3360","affiliations":[{"raw_affiliation_string":"Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), School of Mathematics and Statistics, College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"]},{"raw_affiliation_string":"School of Mathematics and Statistics, College of Information Science and Engineering, Key Laboratory of Computing and Stochastic Mathematics (Ministry of Education), Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100413264","display_name":"Zhonghua Liu","orcid":"https://orcid.org/0009-0004-9422-7632"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhonghua Liu","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0004-9422-7632","affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I173759888","https://openalex.org/I3130607311"],"apc_list":null,"apc_paid":null,"fwci":2.1733,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87320952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"36","issue":"10","first_page":"17650","last_page":"17663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foundation","display_name":"Foundation (evidence)","score":0.7265097498893738},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.7038173079490662},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.6558258533477783},{"id":"https://openalex.org/keywords/adversarial-system","display_name":"Adversarial system","score":0.5532677173614502},{"id":"https://openalex.org/keywords/generative-adversarial-network","display_name":"Generative adversarial network","score":0.4840625822544098},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.4804743826389313},{"id":"https://openalex.org/keywords/transition","display_name":"Transition (genetics)","score":0.4747888445854187},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4653201103210449},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4569026529788971},{"id":"https://openalex.org/keywords/conditional-probability","display_name":"Conditional probability","score":0.4242151379585266},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3724149465560913},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3232559859752655},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.2675599157810211},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2324465811252594},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.1730659008026123},{"id":"https://openalex.org/keywords/political-science","display_name":"Political science","score":0.10478910803794861},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.0844353437423706}],"concepts":[{"id":"https://openalex.org/C2780966255","wikidata":"https://www.wikidata.org/wiki/Q5474306","display_name":"Foundation (evidence)","level":2,"score":0.7265097498893738},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.7038173079490662},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.6558258533477783},{"id":"https://openalex.org/C37736160","wikidata":"https://www.wikidata.org/wiki/Q1801315","display_name":"Adversarial system","level":2,"score":0.5532677173614502},{"id":"https://openalex.org/C2988773926","wikidata":"https://www.wikidata.org/wiki/Q25104379","display_name":"Generative adversarial network","level":3,"score":0.4840625822544098},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.4804743826389313},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.4747888445854187},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4653201103210449},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4569026529788971},{"id":"https://openalex.org/C44492722","wikidata":"https://www.wikidata.org/wiki/Q327069","display_name":"Conditional probability","level":2,"score":0.4242151379585266},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3724149465560913},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3232559859752655},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.2675599157810211},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2324465811252594},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.1730659008026123},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.10478910803794861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0844353437423706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098427","descriptor_name":"Generative Adversarial Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098427","descriptor_name":"Generative Adversarial Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098427","descriptor_name":"Generative Adversarial Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/tnnls.2025.3539006","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tnnls.2025.3539006","pdf_url":null,"source":{"id":"https://openalex.org/S4210175523","display_name":"IEEE Transactions on Neural Networks and Learning Systems","issn_l":"2162-237X","issn":["2162-237X","2162-2388"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Neural Networks and Learning Systems","raw_type":"journal-article"},{"id":"pmid:40031545","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40031545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on neural networks and learning systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4149904471","display_name":null,"funder_award_id":"62372169","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6502659134","display_name":null,"funder_award_id":"62072173","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8734159468","display_name":null,"funder_award_id":"2023JJ30410","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W2767723267","https://openalex.org/W2789727733","https://openalex.org/W2916771055","https://openalex.org/W2919937325","https://openalex.org/W2941052365","https://openalex.org/W2941551392","https://openalex.org/W2991680681","https://openalex.org/W2991909137","https://openalex.org/W3038748576","https://openalex.org/W3083907077","https://openalex.org/W3107734136","https://openalex.org/W3112948680","https://openalex.org/W3134323447","https://openalex.org/W3168015895","https://openalex.org/W3176896397","https://openalex.org/W3196932258","https://openalex.org/W3202035491","https://openalex.org/W3205741601","https://openalex.org/W4206055806","https://openalex.org/W4214920103","https://openalex.org/W4220863829","https://openalex.org/W4220882290","https://openalex.org/W4281634975","https://openalex.org/W4281704579","https://openalex.org/W4296658109","https://openalex.org/W4322773576","https://openalex.org/W4377142567","https://openalex.org/W4383374753","https://openalex.org/W4384484700","https://openalex.org/W4385988359","https://openalex.org/W4386078237","https://openalex.org/W4387344326","https://openalex.org/W4387580644","https://openalex.org/W4387898479","https://openalex.org/W4388430529","https://openalex.org/W4388739212","https://openalex.org/W4388967748","https://openalex.org/W4390023570","https://openalex.org/W4390452010","https://openalex.org/W4390970311","https://openalex.org/W4392693563","https://openalex.org/W4394586019","https://openalex.org/W4395462076","https://openalex.org/W4402457300","https://openalex.org/W4404821554"],"related_works":["https://openalex.org/W2502115930","https://openalex.org/W2482350142","https://openalex.org/W2888032422","https://openalex.org/W2996316059","https://openalex.org/W4377980832","https://openalex.org/W2897769091","https://openalex.org/W2845413374","https://openalex.org/W3005996785","https://openalex.org/W4297411772","https://openalex.org/W4235873501"],"abstract_inverted_index":{"The":[0,192],"risk":[1,17,139,163],"prediction":[2,18,140,164],"of":[3,35,56,63,100,128,141,156,165,179],"Alzheimer's":[4],"disease":[5],"(AD)":[6],"is":[7,91,118],"crucial":[8],"for":[9,176,186],"its":[10],"early":[11,177],"prevention":[12],"and":[13,25,134,154,162],"treatment.":[14],"However,":[15],"current":[16],"methods":[19],"face":[20],"challenges":[21],"in":[22,158],"effectively":[23,77],"extracting":[24],"fusing":[26,131],"multiomics":[27],"features,":[28],"particularly":[29],"overlooking":[30],"the":[31,45,53,60,108,124,146,152],"multilevel":[32],"evolutionary":[33,54,126,159],"mechanisms":[34],"AD.":[36,142,166],"This":[37,120,167],"article":[38,168],"combines":[39],"biomedical":[40,72],"large":[41,73],"foundation":[42,74],"models":[43,75],"with":[44],"conditional":[46,85,112],"generative":[47],"adversarial":[48],"network":[49],"(GAN)":[50],"to":[51,76,93,137],"mine":[52,123],"patterns":[55,127],"AD":[57,95,129,180,190],"by":[58,130],"considering":[59],"regulatory":[61],"effect":[62],"genes":[64],"on":[65,107,145,189],"brain":[66,101,132],"lesions.":[67],"Specifically,":[68],"we":[69],"first":[70],"use":[71],"construct":[78],"high-quality":[79],"imaging":[80,133,148],"genetic":[81,104,135],"features.":[82],"Next,":[83],"a":[84,111,172],"probabilistic":[86,113],"state":[87,98,114],"transition":[88,115],"mathematical":[89,109],"model":[90],"constructed":[92],"describe":[94],"progression":[96],"as":[97],"transitions":[99],"regions":[102],"under":[103],"regulations.":[105],"Based":[106],"model,":[110],"GAN":[116],"(CPST-GAN)":[117],"proposed.":[119],"algorithm":[121,175],"can":[122],"dynamic":[125],"features":[136],"achieve":[138],"Finally,":[143],"experiments":[144],"public":[147],"genetics":[149],"datasets":[150],"validate":[151],"effectiveness":[153],"superiority":[155],"CPST-GAN":[157],"pattern":[160],"mining":[161],"not":[169],"only":[170],"provides":[171],"reliable":[173],"intelligence":[174],"intervention":[178],"but":[181],"also":[182],"offers":[183],"new":[184],"insights":[185],"future":[187],"research":[188],"pathogenesis.":[191],"code":[193],"has":[194],"been":[195],"published":[196],"at":[197],"github.com/fmri123456/CPST-GAN.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
